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geoff coxon
geoff coxon
Verified email at strath.ac.uk
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Year
Current status and research strategies in tuberculosis drug development: miniperspective
LG Dover, GD Coxon
Journal of medicinal Chemistry 54 (18), 6157-6165, 2011
1702011
Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria
A Alahari, X Trivelli, Y Guérardel, LG Dover, GS Besra, JC Sacchettini, ...
PloS one 2 (12), e1343, 2007
1702007
Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice
MH Mooney, S Fogarty, C Stevenson, AM Gallagher, P Palit, SA Hawley, ...
British journal of pharmacology 153 (8), 1669-1677, 2008
952008
Characterisation of triterpenes and new phenolic lipids in Cameroonian propolis
MN Kardar, T Zhang, GD Coxon, DG Watson, J Fearnley, V Seidel
Phytochemistry 106, 156-163, 2014
782014
Synthesis, antitubercular activity and mechanism of resistance of highly effective thiacetazone analogues
GD Coxon, D Craig, RM Corrales, E Vialla, L Gannoun-Zaki, L Kremer
PLoS One 8 (1), e53162, 2013
762013
Identification of 2-Aminothiazole-4-Carboxylate Derivatives Active against Mycobacterium tuberculosis H37Rv and the β-Ketoacyl-ACP Synthase mtFabH
Q Al-Balas, NG Anthony, B Al-Jaidi, A Alnimr, G Abbott, AK Brown, ...
PLoS One 4 (5), e5617, 2009
762009
Resistance to thiacetazone derivatives active against Mycobacterium abscessus involves mutations in the MmpL5 transcriptional repressor MAB_4384
I Halloum, A Viljoen, V Khanna, D Craig, C Bouchier, R Brosch, G Coxon, ...
Antimicrobial agents and chemotherapy 61 (4), 10.1128/aac. 02509-16, 2017
652017
Identification of the benzodiazepines as a new class of antileishmanial agent
RL Clark, KC Carter, AB Mullen, GD Coxon, G Owusu-Dapaah, ...
Bioorganic & medicinal chemistry letters 17 (3), 624-627, 2007
652007
Symmetrical and unsymmetrical analogues of isoxyl; active agents against Mycobacterium tuberculosis
V Bhowruth, AK Brown, RC Reynolds, GD Coxon, SP Mackay, ...
Bioorganic & medicinal chemistry letters 16 (18), 4743-4747, 2006
592006
The synthesis of (11R, 12S)-lactobacillic acid and its enantiomer
GD Coxon, JR Al-Dulayymi, MS Baird, S Knobl, E Roberts, DE Minnikin
Tetrahedron: Asymmetry 14 (9), 1211-1222, 2003
342003
Benzylguanidines and other galegine analogues inducing weight loss in mice
GD Coxon, BL Furman, AL Harvey, J McTavish, MH Mooney, M Arastoo, ...
Journal of medicinal chemistry 52 (11), 3457-3463, 2009
332009
Strategies and challenges involved in the discovery of new chemical entities during early-stage tuberculosis drug discovery
GD Coxon, CB Cooper, SH Gillespie, TD McHugh
Journal of Infectious Diseases 205 (suppl_2), S258-S264, 2012
302012
The synthesis of both enantiomers of lactobacillic acid and mycolic acid analogues
GD Coxon, S Knobl, E Roberts, MS Baird, JR Al Dulayymi, GS Besra, ...
Tetrahedron letters 40 (36), 6689-6692, 1999
271999
Synthesis and properties of methyl 5-(1′ R, 2′ S)-(2-octadecylcycloprop-1-yl) pentanoate and other ω-19 chiral cyclopropane fatty acids and esters related to mycobacterial …
GD Coxon, R Juma’a, C Morehouse, PJ Brennan, GS Besra, MS Baird, ...
Chemistry and physics of lipids 127 (1), 35-46, 2004
162004
Synthesis of cis, cis-diunsaturated α-meromycolic acid by a palladium-catalysed alkyl–alkyl Negishi reaction
G Berretta, GD Coxon
Tetrahedron letters 53 (2), 214-216, 2012
72012
Facile synthesis of (Z)-tetracos-5-enoic acid and racemic cis-4-(2-octadecylcyclopropane-1-yl)-butanoic acid
GD Coxon, JD Douglas, DE Minnikin
Chemistry and physics of lipids 126 (1), 49-53, 2003
72003
Asymmetric and Regiospecific Synthesis of Isotopically Labelled Cyclopropane Fatty Acid (9R, 10S)-Dihydrosterculic Acid: Overcoming Spontaneous Protonation During Lithium …
SWJ Shields, PH Buist, JM Manthorpe
SynOpen 2 (02), 0168-0175, 2018
12018
Synthesis and crystal structures of 3-hydroxy-2, 4-dimethyl-2H-thiophen-5-one and 3-hydroxy-4-methyl-2H-thiophen-5-one
A Nashawi, CP Lawson, MO Abdel-Sattar, JH Ter Horst, GD Coxon, ...
Acta Crystallographica Section E: Crystallographic Communications 76 (7 …, 2020
2020
Written Evidence from TBD-UK, Dr Geoff Coxon
G Coxon
2012
Discovery and development of new TB drugs
G Coxon
All Parliamentary Group on Global Tuberculosis, 2011
2011
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Articles 1–20