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Title / AuthorCited by Year
Identification of a novel arabinofuranosyltransferase (AftA) involved in cell wall arabinan biosynthesis in Mycobacterium tuberculosis
LJ Alderwick, M Seidel, H Sahm, GS Besra, L Eggeling
Journal of Biological Chemistry 281 (23), 15653-15661
Deletion of Cg-emb in corynebacterianeae leads to a novel truncated cell wall arabinogalactan, whereas inactivation of Cg-ubiA results in an arabinan-deficient mutant with a cell wall galactan core
LJ Alderwick, E Radmacher, M Seidel, R Gande, PG Hitchen, HR Morris, ...
Journal of Biological Chemistry 280 (37), 32362-32371
Ethambutol, a cell wall inhibitor of Mycobacterium tuberculosis, elicits L-glutamate efflux of Corynebacterium glutamicum
E Radmacher, KC Stansen, GS Besra, LJ Alderwick, WN Maughan, ...
Microbiology 151 (5), 1359-1368
Identification of a novel arabinofuranosyltransferase AftB involved in a terminal step of cell wall arabinan biosynthesis in Corynebacterianeae, such as Corynebacterium glutamicum and Mycobacterium tuberculosis
M Seidel, LJ Alderwick, HL Birch, H Sahm, L Eggeling, GS Besra
Journal of Biological Chemistry 282 (20), 14729-14740
Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacteriumtuberculosis
LJ Alderwick, V Molle, L Kremer, AJ Cozzone, TR Dafforn, GS Besra, ...
Proceedings of the National Academy of Sciences of the United States of ...
Structure, function and biosynthesis of the Mycobacterium tuberculosis cell wall: arabinogalactan and lipoarabinomannan assembly with a view to discovering new drug targets
LJ Alderwick, HL Birch, AK Mishra, L Eggeling, GS Besra
Biochemical Society Transactions 35 (5), 1325-1328
Biosynthesis of mycobacterial arabinogalactan: identification of a novel α (1→ 3) arabinofuranosyltransferase
HL Birch, LJ Alderwick, A Bhatt, D Rittmann, K Krumbach, A Singh, Y Bai, ...
Molecular microbiology 69 (5), 1191-1206
Identification of an α (1→ 6) mannopyranosyltransferase (MptA), involved in Corynebacterium glutamicum lipomanann biosynthesis, and identification of its orthologue in Mycobacterium tuberculosis
AK Mishra, LJ Alderwick, D Rittmann, RVV Tatituri, J Nigou, M Gilleron, ...
Molecular microbiology 65 (6), 1503-1517
Two functional FAS-I type fatty acid synthases in Corynebacterium glutamicum
E Radmacher, LJ Alderwick, GS Besra, AK Brown, KJC Gibson, H Sahm, ...
Microbiology 151 (7), 2421-2427
Identification of a novel α (1→ 6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan‐and lipoarabinomannan‐deficient mutant
AK Mishra, LJ Alderwick, D Rittmann, C Wang, A Bhatt, WR Jacobs Jr, ...
Molecular microbiology 68 (6), 1595-1613
Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors
SM Batt, T Jabeen, V Bhowruth, L Quill, PA Lund, L Eggeling, ...
Proceedings of the National Academy of Sciences 109 (28), 11354-11359
Topology and mutational analysis of the single Emb arabinofuranosyltransferase of Corynebacterium glutamicum as a model of Emb proteins of Mycobacterium tuberculosis
M Seidel, LJ Alderwick, H Sahm, GS Besra, L Eggeling
Glycobiology 17 (2), 210-219
Arabinan-deficient mutants of Corynebacterium glutamicum and the consequent flux in decaprenylmonophosphoryl-D-arabinose metabolism
LJ Alderwick, LG Dover, M Seidel, R Gande, H Sahm, L Eggeling, ...
Glycobiology 16 (11), 1073-1081
A truncated lipoglycan from mycobacteria with altered immunological properties
HL Birch, LJ Alderwick, BJ Appelmelk, J Maaskant, A Bhatt, A Singh, ...
Proceedings of the National Academy of Sciences 107 (6), 2634-2639
Structural characterization and functional properties of a novel lipomannan variant isolated from a Corynebacterium glutamicum pimB′ mutant
AK Mishra, C Klein, SS Gurcha, LJ Alderwick, P Babu, PG Hitchen, ...
Antonie Van Leeuwenhoek 94 (2), 277-287
Expression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in< i> Mycobacterium tuberculosis</i>
LJ Alderwick, LG Dover, N Veerapen, SS Gurcha, L Kremer, DL Roper, ...
Protein expression and purification 58 (2), 332-341
Structural characterization of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiA mutant
RVV Tatituri, LJ Alderwick, AK Mishra, J Nigou, M Gilleron, K Krumbach, ...
Microbiology 153 (8), 2621-2629
The C-terminal domain of the Arabinosyltransferase Mycobacterium tuberculosis EmbC is a lectin-like carbohydrate binding module
LJ Alderwick, GS Lloyd, H Ghadbane, JW May, A Bhatt, L Eggeling, ...
PLoS pathogens 7 (2), e1001299
Tuberculosis: a balanced diet of lipids and carbohydrates.
V Bhowruth, LJ Alderwick, AK Brown, A Bhatt, GS Besra
Biochemical Society Transactions 36 (Pt 4), 555-565
EmbR2, a structural homologue of EmbR, inhibits the Mycobacterium tuberculosis kinase/substrate pair PknH/EmbR
V Molle, R Reynolds, L Alderwick, G Besra, A Cozzone, K Futterer, ...
Biochem. J 410, 309-317
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