A natural plasmid uniquely encodes two biosynthetic pathways creating a potent anti-MRSA antibiotic D Fukuda, AS Haines, Z Song, AC Murphy, J Hothersall, ER Stephens, ... PLoS One 6 (3), e18031, 2011 | 85 | 2011 |
Iterative mechanism of macrodiolide formation in the anticancer compound conglobatin Y Zhou, AC Murphy, M Samborskyy, P Prediger, LC Dias, PF Leadlay Chemistry & biology 22 (6), 745-754, 2015 | 75 | 2015 |
Evolving trends in the dereplication of natural product extracts. 2. The isolation of chrysaibol, an antibiotic peptaibol from a New Zealand sample of the mycoparasitic fungus … MI Mitova, AC Murphy, G Lang, JW Blunt, ALJ Cole, G Ellis, MHG Munro Journal of natural products 71 (9), 1600-1603, 2008 | 57 | 2008 |
Broadening substrate specificity of a chain-extending ketosynthase through a single active-site mutation AC Murphy, H Hong, S Vance, RW Broadhurst, PF Leadlay Chemical Communications 52 (54), 8373-8376, 2016 | 51 | 2016 |
Engineered thiomarinol antibiotics active against MRSA are generated by mutagenesis and mutasynthesis of Pseudoalteromonas SANK73390 AC Murphy, D Fukuda, Z Song, J Hothersall, RJ Cox, CL Willis, ... Angewandte Chemie 123 (14), 3329-3332, 2011 | 51 | 2011 |
Biosynthesis of Mupirocin by Pseudomonas fluorescens NCIMB 10586 Involves Parallel Pathways SS Gao, J Hothersall, J Wu, AC Murphy, Z Song, ER Stephens, ... Journal of the American Chemical Society 136 (14), 5501-5507, 2014 | 46 | 2014 |
Biosynthesis of thiomarinol A and related metabolites of Pseudoalteromonas sp. SANK 73390 AC Murphy, SS Gao, LC Han, S Carobene, D Fukuda, Z Song, ... Chemical Science 5 (1), 397-402, 2014 | 43 | 2014 |
Macrodiolide formation by the thioesterase of a modular polyketide synthase Y Zhou, P Prediger, LC Dias, AC Murphy, PF Leadlay Angewandte Chemie 127 (17), 5321-5324, 2015 | 42 | 2015 |
Metabolic engineering is key to a sustainable chemical industry AC Murphy Natural product reports 28 (8), 1406-1425, 2011 | 38 | 2011 |
Concise, Stereoselective Route to the Four Diastereoisomers of 4-Methylproline AC Murphy, MI Mitova, JW Blunt, MHG Munro Journal of natural products 71 (5), 806-809, 2008 | 31 | 2008 |
Manipulation of quorum sensing regulation in Pseudomonas fluorescens NCIMB 10586 to increase mupirocin production J Hothersall, AC Murphy, Z Iqbal, G Campbell, ER Stephens, J Wu, ... Applied microbiology and biotechnology 90, 1017-1026, 2011 | 26 | 2011 |
Structure of the fundamental lipopeptide surfactin at the air/water interface investigated by sum frequency generation spectroscopy SA Goussous, MTL Casford, AC Murphy, GPC Salmond, FJ Leeper, ... The Journal of Physical Chemistry B 121 (19), 5072-5077, 2017 | 25 | 2017 |
Pteratides I-IV, new cytotoxic cyclodepsipeptides from the Malaysian basidiomycete Pterula sp. CH Chen, G Lang, MI Mitova, AC Murphy, ALJ Cole, LB Din, JW Blunt, ... The Journal of organic chemistry 71 (21), 7947-7951, 2006 | 20 | 2006 |
Synthetic and biological studies on the spiro-mamakone system AC Murphy, SRA Devenish, AC Muscroft-Taylor, JW Blunt, MHG Munro Organic & biomolecular chemistry 6 (20), 3854-3862, 2008 | 17 | 2008 |
A vitamin K-dependent carboxylase orthologue is involved in antibiotic biosynthesis BJC Law, Y Zhuo, M Winn, D Francis, Y Zhang, M Samborskyy, A Murphy, ... Nature Catalysis 1 (12), 977-984, 2018 | 15 | 2018 |
Enantioselective Syntheses of α-Fmoc-Pbf-[2-13C]-l-arginine and Fmoc-[1, 3-13C2]-l-proline and Incorporation into the Neurotensin Receptor 1 Ligand, NT8− 13 C Song, S Tapaneeyakorn, AC Murphy, C Butts, A Watts, CL Willis The Journal of organic chemistry 74 (23), 8980-8987, 2009 | 15 | 2009 |
Mupirocin F: structure elucidation, synthesis and rearrangements RW Scott, AC Murphy, J Wu, J Hothersall, RJ Cox, TJ Simpson, ... Tetrahedron 67 (27-28), 5098-5106, 2011 | 10 | 2011 |
Solanimycin: Biosynthesis and Distribution of a New Antifungal Antibiotic Regulated by Two Quorum-Sensing Systems MA Matilla, RE Monson, A Murphy, M Schicketanz, A Rawlinson, ... Mbio 13 (6), e02472-22, 2022 | 9 | 2022 |
Biosynthesis of Antifungal Solanimycin May Involve an Iterative Nonribosomal Peptide Synthetase Module AC Murphy, M Corney, RE Monson, MA Matilla, GPC Salmond, FJ Leeper ACS Chemical Biology, 2023 | 1 | 2023 |
A Natural Plasmid Uniquely Encodes Two Biosynthetic Pathways Creating a Potent Anti-MRSA Antibiotic (vol 6, e18031, 2011) D Fukuda, AS Haines, Z Song, AC Murphy, J Hothersall PLOS ONE 9 (12), 2014 | | 2014 |