| Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment I Kufareva, M Rueda, V Katritch, participants GPCR-Dock-2010, ... Structure 19 (8), 1108-1126, 2011 | 345 | 2011 |
| Advances in GPCR Modeling Evaluated by the GPCR Dock 2013 Assessment: Meeting New Challenges I Kufareva, V Katritch, PGD 2013, RC Stevens, R Abagyan Structure, 2014 | 181 | 2014 |
| Discovery of novel agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screening IG Tikhonova, CS Sum, S Neumann, S Engel, BM Raaka, S Costanzi, ... Journal of medicinal chemistry 51 (3), 625-633, 2008 | 171 | 2008 |
| Identification of residues important for agonist recognition and activation in GPR40 CS Sum, IG Tikhonova, S Neumann, S Engel, BM Raaka, S Costanzi, ... Journal of Biological Chemistry 282 (40), 29248-29255, 2007 | 141 | 2007 |
| Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3 BD Hudson, IG Tikhonova, SK Pandey, T Ulven, G Milligan Journal of Biological Chemistry 287 (49), 41195-41209, 2012 | 129 | 2012 |
| Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3 J Schmidt, NJ Smith, E Christiansen, IG Tikhonova, M Grundmann, ... Journal of Biological Chemistry 286 (12), 10628-10640, 2011 | 128 | 2011 |
| Bidirectional, iterative approach to the structural delineation of the functional “chemoprint” in GPR40 for agonist recognition IG Tikhonova, CS Sum, S Neumann, CJ Thomas, BM Raaka, S Costanzi, ... Journal of medicinal chemistry 50 (13), 2981-2989, 2007 | 112 | 2007 |
| Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor BD Hudson, ME Due-Hansen, E Christiansen, AM Hansen, AE Mackenzie, ... Journal of Biological Chemistry 288 (24), 17296-17312, 2013 | 104 | 2013 |
| Rhodopsin and the others: a historical perspective on structural studies of G protein-coupled receptors S Costanzi, J Siegel, IG Tikhonova, KA Jacobson Current pharmaceutical design 15 (35), 3994-4002, 2009 | 84 | 2009 |
| Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs BD Hudson, E Christiansen, IG Tikhonova, M Grundmann, E Kostenis, ... The FASEB Journal 26 (12), 4951, 2012 | 81 | 2012 |
| Old drug, new target: ellipticines selectively inhibit RNA polymerase I transcription WJ Andrews, T Panova, C Normand, O Gadal, IG Tikhonova, KI Panov Journal of Biological Chemistry 288 (7), 4567-4582, 2013 | 79 | 2013 |
| Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator NJ Smith, RJ Ward, LA Stoddart, BD Hudson, E Kostenis, T Ulven, ... Molecular pharmacology 80 (1), 163-173, 2011 | 79 | 2011 |
| Two arginine-glutamate ionic locks near the extracellular surface of FFAR1 gate receptor activation CS Sum, IG Tikhonova, S Costanzi, MC Gershengorn Journal of biological chemistry 284 (6), 3529-3536, 2009 | 65 | 2009 |
| Identification of determinants of glucose-dependent insulinotropic polypeptide receptor that interact with N-terminal biologically active region of the natural ligand T Yaqub, IG Tikhonova, J Lättig, R Magnan, M Laval, C Escrieut, ... Molecular pharmacology 77 (4), 547-558, 2010 | 63 | 2010 |
| Probing the mid-gorge of cholinesterases with spacer-modified bivalent quinazolinimines leads to highly potent and selective butyrylcholinesterase inhibitors X Chen, IG Tikhonova, M Decker Bioorganic & medicinal chemistry 19 (3), 1222-1235, 2011 | 59 | 2011 |
| Simulations of Biased Agonists in the β2 Adrenergic Receptor with Accelerated Molecular Dynamics IG Tikhonova, B Selvam, A Ivetac, J Wereszczynski, JA McCammon Biochemistry 52 (33), 5593-5603, 2013 | 54 | 2013 |
| Structural basis for understanding structure− activity relationships for the glutamate binding site of the NMDA receptor IG Tikhonova, II Baskin, VA Palyulin, NS Zefirov, SO Bachurin Journal of medicinal chemistry 45 (18), 3836-3843, 2002 | 53 | 2002 |
| Modeled structure of a G-protein-coupled receptor: the cholecystokinin-1 receptor E Archer-Lahlou, I Tikhonova, C Escrieut, M Dufresne, C Seva, ... Journal of medicinal chemistry 48 (1), 180-191, 2005 | 52 | 2005 |
| Insights into the binding and activation sites of the receptors for cholecystokinin and gastrin M Foucaud, E Archer-Lahlou, E Marco, IG Tikhonova, B Maigret, ... Regulatory peptides 145 (1-3), 17-23, 2008 | 49 | 2008 |
| GPCR structure, function, drug discovery and crystallography: report from academia-industry international conference (UK Royal Society) Chicheley Hall, 1–2 September 2014 A Heifetz, GFX Schertler, R Seifert, CG Tate, PM Sexton, VV Gurevich, ... Naunyn-Schmiedeberg's archives of pharmacology 388, 883-903, 2015 | 47 | 2015 |
Graeme MilliganUniversity of GlasgowVerified email at glasgow.ac.uk
