| The first direct and enantioselective cross-aldol reaction of aldehydes AB Northrup, DWC MacMillan Journal of the American Chemical Society 124 (24), 6798-6799, 2002 | 930 | 2002 |
| The first general enantioselective catalytic Diels− Alder reaction with simple α, β-unsaturated ketones AB Northrup, DWC MacMillan Journal of the American Chemical Society 124 (11), 2458-2460, 2002 | 598 | 2002 |
| Two-step synthesis of carbohydrates by selective aldol reactions AB Northrup, DWC MacMillan Science 305 (5691), 1752-1755, 2004 | 484 | 2004 |
| Enantioselective organocatalytic direct aldol reactions of α‐oxyaldehydes: step one in a two‐step synthesis of carbohydrates AB Northrup, IK Mangion, F Hettche, DWC MacMillan Angewandte Chemie International Edition 43 (16), 2152-2154, 2004 | 401 | 2004 |
| The importance of iminium geometry control in enamine catalysis: identification of a new catalyst architecture for aldehyde–aldehyde couplings IK Mangion, AB Northrup, DWC MacMillan Angewandte Chemie International Edition 43 (48), 6722-6724, 2004 | 229 | 2004 |
| Total synthesis and structural revision of callipeltoside C J Carpenter, AB Northrup, JJM Wiener, SG Kim, DWC MacMillan Angewandte Chemie (International ed. in English) 47 (19), 3568, 2008 | 108 | 2008 |
| 11 Brochu, MP, Brown, SP, and MacMillan, DWC J AB Northrup Am. Chem. Soc 124, 6798-6799, 2002 | 86 | 2002 |
| Genetic and pharmacological inhibition of PDK1 in cancer cells: characterization of a selective allosteric kinase inhibitor K Nagashima, SD Shumway, S Sathyanarayanan, AH Chen, B Dolinski, ... Journal of biological chemistry 286 (8), 6433-6448, 2011 | 78 | 2011 |
| A kinase-cGAS cascade to synthesize a therapeutic STING activator JA McIntosh, Z Liu, BM Andresen, NS Marzijarani, JC Moore, NM Marshall, ... Nature 603 (7901), 439-444, 2022 | 62 | 2022 |
| Discovery of PDK1 kinase inhibitors with a novel mechanism of action by ultrahigh throughput screening EV Bobkova, MJ Weber, Z Xu, YL Zhang, J Jung, P Blume-Jensen, ... Journal of biological chemistry 285 (24), 18838-18846, 2010 | 58 | 2010 |
| Discovery of MK-1454: a potent cyclic dinucleotide stimulator of interferon genes agonist for the treatment of cancer W Chang, MD Altman, CA Lesburg, SA Perera, JA Piesvaux, ... Journal of Medicinal Chemistry 65 (7), 5675-5689, 2022 | 53 | 2022 |
| Aminopyrimidines as Syk inhibitors MD Altman, KL Arrington, J Burch, B Cote, JF Fournier, JY Gauthier, ... US Patent 8,735,417, 2014 | 41 | 2014 |
| Discovery of 1-[3-(1-Methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific … AB Northrup, MH Katcher, MD Altman, M Chenard, MH Daniels, ... Journal of Medicinal Chemistry 56 (6), 2294-2310, 2013 | 35 | 2013 |
| PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models K Ellwood-Yen, H Keilhack, K Kunii, B Dolinski, Y Connor, K Hu, ... Cancer research 71 (8), 3052-3065, 2011 | 35 | 2011 |
| Development of High-Throughput TR-FRET and AlphaScreen® Assays for Identification of Potent Inhibitors of PDK1 Z Xu, K Nagashima, D Sun, T Rush, A Northrup, JN Andersen, I Kariv, ... SLAS Discovery 14 (10), 1257-1262, 2009 | 34 | 2009 |
| Aminopyrimidines as SYK inhibitors MD Altman, BM Andresen, KL Arrington, J Burch, KK Childers, B Cote, ... US Patent 8,551,984, 2013 | 32 | 2013 |
| A new strategy for the synthesis of benzylic sulfonamides: palladium-catalyzed arylation and sulfonamide metathesis JB Grimm, MH Katcher, DJ Witter, AB Northrup The Journal of Organic Chemistry 72 (21), 8135-8138, 2007 | 32 | 2007 |
| Inhibition of spleen tyrosine kinase attenuates allergen-mediated airway constriction LY Moy, Y Jia, M Caniga, G Lieber, M Gil, X Fernandez, E Sirkowski, ... American journal of respiratory cell and molecular biology 49 (6), 1085-1092, 2013 | 31 | 2013 |
| Analyzing the potential root causes of variability of pharmacokinetics in preclinical species P Daublain, KI Feng, MD Altman, I Martin, S Mukherjee, R Nofsinger, ... Molecular Pharmaceutics 14 (5), 1634-1645, 2017 | 28 | 2017 |
| Identification of direct target engagement biomarkers for kinase-targeted therapeutics CP Paweletz, JN Andersen, R Pollock, K Nagashima, ML Hayashi, SU Yu, ... PLoS One 6 (10), e26459, 2011 | 26 | 2011 |
