International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma KF Chung, SE Wenzel, JL Brozek, A Bush, M Castro, PJ Sterk, IM Adcock, ... European respiratory journal 43 (2), 343-373, 2014 | 4283 | 2014 |
Decreased histone deacetylase activity in chronic obstructive pulmonary disease K Ito, M Ito, WM Elliott, B Cosio, G Caramori, OM Kon, A Barczyk, ... New England Journal of Medicine 352 (19), 1967-1976, 2005 | 1223 | 2005 |
Glucocorticoid resistance in inflammatory diseases PJ Barnes, IM Adcock The Lancet 373 (9678), 1905-1917, 2009 | 1210 | 2009 |
Oxidative stress and redox regulation of lung inflammation in COPD I Rahman, IM Adcock European respiratory journal 28 (1), 219-242, 2006 | 1204 | 2006 |
How corticosteroids control inflammation: quintiles prize lecture 2005 PJ Barnes British journal of pharmacology 148 (3), 245-254, 2006 | 1081 | 2006 |
Anti-inflammatory actions of steroids: molecular mechanisms PJ Barnes, I Adcock, M Spedding, PM Vanhoutte Trends in pharmacological sciences 14 (12), 436-441, 1993 | 1078 | 1993 |
Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1β-induced histone H4 acetylation on lysines 8 and 12 K Ito, PJ Barnes, IM Adcock Molecular and cellular biology, 2000 | 969 | 2000 |
Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction KF Chung, IM Adcock European Respiratory Journal 31 (6), 1334-1356, 2008 | 810 | 2008 |
Histone deacetylase 2–mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression K Ito, S Yamamura, S Essilfie-Quaye, B Cosio, M Ito, PJ Barnes, ... The Journal of experimental medicine 203 (1), 7-13, 2006 | 803 | 2006 |
Histone acetylation and deacetylation: importance in inflammatory lung diseases PJ Barnes, IM Adcock, K Ito European Respiratory Journal 25 (3), 552-563, 2005 | 744 | 2005 |
A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression K Ito, S Lim, G Caramori, B Cosio, KF Chung, IM Adcock, PJ Barnes Proceedings of the National Academy of Sciences 99 (13), 8921-8926, 2002 | 663 | 2002 |
Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages K Ito, S Lim, G Caramori, KF Chung, PJ Barnes, IM Adcock The FASEB Journal 15 (6), 1110-1112, 2001 | 652 | 2001 |
Increased expression of nuclear factor-κB in bronchial biopsies from smokers and patients with COPD A Di Stefano, G Caramori, T Oates, A Capelli, M Lusuardi, I Gnemmi, F Ioli, ... European Respiratory Journal 20 (3), 556-563, 2002 | 620 | 2002 |
Activation and localization of transcription factor, nuclear factor-κ B, in asthma LA Hart, VL Krishnan, IM Adcock, PJ Barnes, KF Chung American journal of respiratory and critical care medicine 158 (5), 1585-1592, 1998 | 598 | 1998 |
Update on glucocorticoid action and resistance K Ito, KF Chung, IM Adcock Journal of Allergy and Clinical Immunology 117 (3), 522-543, 2006 | 592 | 2006 |
Trichostatin A Is a Histone Deacetylase Inhibitor with Potent Antitumor Activity against Breast Cancer in Vivo DM Vigushin, S Ali, PE Pace, N Mirsaidi, K Ito, I Adcock, RC Coombes Clinical Cancer Research 7 (4), 971-976, 2001 | 589 | 2001 |
Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in children with difficult asthma, after treatment with oral prednisolone DNR PAYNE, IANM ADCOCK, NM WILSON, TIM Oates, M SCALLAN, ... American journal of respiratory and critical care medicine 164 (8), 1376-1381, 2001 | 582 | 2001 |
Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort DE Shaw, AR Sousa, SJ Fowler, LJ Fleming, G Roberts, J Corfield, ... European Respiratory Journal 46 (5), 1308-1321, 2015 | 579 | 2015 |
Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages BG Cosio, L Tsaprouni, K Ito, E Jazrawi, IM Adcock, PJ Barnes The Journal of experimental medicine 200 (5), 689-695, 2004 | 574 | 2004 |
p38 Mitogen-activated protein kinase–induced glucocorticoid receptor phosphorylation reduces its activity: Role in steroid-insensitive asthma E Irusen, JG Matthews, A Takahashi, PJ Barnes, KF Chung, IM Adcock Journal of Allergy and Clinical Immunology 109 (4), 649-657, 2002 | 567 | 2002 |