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Title / AuthorCited by Year
A highly conserved repeated DNA element located in the chromosome of Streptococcus pneumoniae
B Martin, O Humbert, M Camara, E Guenzi, J Walker, T Mitchell, P Andrew, ...
Nucleic acids research 20 (13), 3479-3483
Rapid pneumococcal evolution in response to clinical interventions
NJ Croucher, SR Harris, C Fraser, MA Quail, J Burton, M van der Linden, ...
Science 331 (6016), 430-434
Pneumococcal pneumolysin and H< sub> 2</sub> O< sub> 2</sub> mediate brain cell apoptosis during meningitis
JS Braun, JE Sublett, D Freyer, TJ Mitchell, JL Cleveland, EI Tuomanen, ...
The Journal of clinical investigation 109 (1), 19-27
Molecular analysis of the pathogenicity of Streptococcus pneumoniae: the role of pneumococcal proteins
JC Paton, PW Andrew, GJ Boulnois, TJ Mitchell
Annual Reviews in Microbiology 47 (1), 89-115
Immunization of mice with pneumolysin toxoid confers a significant degree of protection against at least nine serotypes of Streptococcus pneumoniae.
JE Alexander, RA Lock, CC Peeters, JT Poolman, PW Andrew, TJ Mitchell, ...
Infection and immunity 62 (12), 5683-5688
Competence-programmed predation of noncompetent cells in the human pathogen Streptococcus pneumoniae: genetic requirements
S Guiral, TJ Mitchell, B Martin, JP Claverys
Proceedings of the National Academy of Sciences of the United States of ...
Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear phagocytes.
S Houldsworth, PW Andrew, TJ Mitchell
Infection and immunity 62 (4), 1501-1503
Microarray-based identification of a novelStreptococcus pneumoniae regulon controlled by an autoinduced peptide
A de Saizieu, C Gardès, N Flint, C Wagner, M Kamber, TJ Mitchell, ...
Journal of bacteriology 182 (17), 4696-4703
The pathogenesis of streptococcal infections: from tooth decay to meningitis
TJ Mitchell
Nature Reviews Microbiology 1 (3), 219-230
Purification and immunogenicity of genetically obtained pneumolysin toxoids and their conjugation to Streptococcus pneumoniae type 19F polysaccharide.
JC Paton, RA Lock, CJ Lee, JP Li, AM Berry, TJ Mitchell, PW Andrew, ...
Infection and immunity 59 (7), 2297-2304
Host cellular immune response to pneumococcal lung infection in mice
A Kadioglu, NA Gingles, K Grattan, A Kerr, TJ Mitchell, PW Andrew
Infection and immunity 68 (2), 492-501
The role of pneumolysin and autolysin in the pathology of pneumonia and septicemia in mice infected with a type 2 pneumococcus
JR Canvin, AP Marvin, M Sivakumaran, JC Paton, GJ Boulnois, ...
Journal of Infectious Diseases 172 (1), 119-123
Complement activation and antibody binding by pneumolysin via a region of the toxin homologous to a human acute‐phase protein
TJ Mitchell, PW Andrew, FK Saunders, AN Smith, GJ Boulnois
Molecular microbiology 5 (8), 1883-1888
A neuraminidase from Streptococcus pneumoniae has the features of a surface protein.
M Camara, GJ Boulnois, PW Andrew, TJ Mitchell
Infection and immunity 62 (9), 3688-3695
The biology of Gram-positive sortase enzymes
GK Paterson, TJ Mitchell
Trends in microbiology 12 (2), 89-95
Structure and function of pneumolysin, the multifunctional, thiol‐activated toxin of Streptococcus pneumoniae
GJ Boulnois, JC Paton, TJ Mitchell, PW Andrew
Molecular microbiology 5 (11), 2611-2616
Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon.
TJ Mitchell, JM Ketley, SC Haslam, J Stephen, DW Burdon, DC Candy, ...
Gut 27 (1), 78-85
Effect of Streptococcus pneumoniae on human respiratory epithelium in vitro.
C Steinfort, R Wilson, T Mitchell, C Feldman, A Rutman, H Todd, D Sykes, ...
Infection and immunity 57 (7), 2006-2013
Pneumolysin, the thiol-activated toxin of Streptococcus pneumoniae, does not require a thiol group for in vitro activity.
FK Saunders, TJ Mitchell, JA Walker, PW Andrew, GJ Boulnois
Infection and immunity 57 (8), 2547-2552
Dual function of pneumolysin in the early pathogenesis of murine pneumococcal pneumonia.
JB Rubins, D Charboneau, JC Paton, TJ Mitchell, PW Andrew, EN Janoff
Journal of Clinical Investigation 95 (1), 142
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