|Rapid pneumococcal evolution in response to clinical interventions|
NJ Croucher, SR Harris, C Fraser, MA Quail, J Burton, M van der Linden, ...
Science 331 (6016), 430-434, 2011
|A highly conserved repeated DNA element located in the chromosome of Streptococcus pneumoniae|
B Martin, O Humbert, M Camara, E Guenzi, J Walker, T Mitchell, P Andrew, ...
Nucleic acids research 20 (13), 3479-3483, 1992
|Pneumococcal pneumolysin and H 2 O 2 mediate brain cell apoptosis during meningitis|
JS Braun, JE Sublett, D Freyer, TJ Mitchell, JL Cleveland, EI Tuomanen, ...
The Journal of clinical investigation 109 (109 (1)), 19-27, 2002
|Molecular analysis of the pathogenicity of Streptococcus pneumoniae: the role of pneumococcal proteins|
JC Paton, PW Andrew, GJ Boulnois, TJ Mitchell
Annual Reviews in Microbiology 47 (1), 89-115, 1993
|Immunization of mice with pneumolysin toxoid confers a significant degree of protection against at least nine serotypes of Streptococcus pneumoniae.|
JE Alexander, RA Lock, CC Peeters, JT Poolman, PW Andrew, TJ Mitchell, ...
Infection and immunity 62 (12), 5683-5688, 1994
|Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear phagocytes.|
S Houldsworth, PW Andrew, TJ Mitchell
Infection and immunity 62 (4), 1501-1503, 1994
|Competence-programmed predation of noncompetent cells in the human pathogen Streptococcus pneumoniae: genetic requirements|
S Guiral, TJ Mitchell, B Martin, JP Claverys
Proceedings of the National Academy of Sciences of the United States of ..., 2005
|Microarray-based identification of a novelStreptococcus pneumoniae regulon controlled by an autoinduced peptide|
A de Saizieu, C Gardès, N Flint, C Wagner, M Kamber, TJ Mitchell, ...
Journal of bacteriology 182 (17), 4696-4703, 2000
|The pathogenesis of streptococcal infections: from tooth decay to meningitis|
Nature Reviews Microbiology 1 (3), 219-230, 2003
|Host cellular immune response to pneumococcal lung infection in mice|
A Kadioglu, NA Gingles, K Grattan, A Kerr, TJ Mitchell, PW Andrew
Infection and immunity 68 (2), 492-501, 2000
|Purification and immunogenicity of genetically obtained pneumolysin toxoids and their conjugation to Streptococcus pneumoniae type 19F polysaccharide.|
JC Paton, RA Lock, CJ Lee, JP Li, AM Berry, TJ Mitchell, PW Andrew, ...
Infection and immunity 59 (7), 2297-2304, 1991
|The role of pneumolysin and autolysin in the pathology of pneumonia and septicemia in mice infected with a type 2 pneumococcus|
JR Canvin, AP Marvin, M Sivakumaran, JC Paton, GJ Boulnois, ...
Journal of Infectious Diseases 172 (1), 119-123, 1995
|Complement activation and antibody binding by pneumolysin via a region of the toxin homologous to a human acute‐phase protein|
TJ Mitchell, PW Andrew, FK Saunders, AN Smith, GJ Boulnois
Molecular microbiology 5 (8), 1883-1888, 1991
|A neuraminidase from Streptococcus pneumoniae has the features of a surface protein.|
M Camara, GJ Boulnois, PW Andrew, TJ Mitchell
Infection and immunity 62 (9), 3688-3695, 1994
|The biology of Gram-positive sortase enzymes|
GK Paterson, TJ Mitchell
Trends in microbiology 12 (2), 89-95, 2004
|Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon.|
TJ Mitchell, JM Ketley, SC Haslam, J Stephen, DW Burdon, DC Candy, ...
Gut 27 (1), 78-85, 1986
|Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species|
C Donati, NL Hiller, H Tettelin, A Muzzi, NJ Croucher, SV Angiuoli, ...
Genome biology 11 (10), R107, 2010
|Structure and function of pneumolysin, the multifunctional, thiol‐activated toxin of Streptococcus pneumoniae|
GJ Boulnois, JC Paton, TJ Mitchell, PW Andrew
Molecular microbiology 5 (11), 2611-2616, 1991
|Effect of Streptococcus pneumoniae on human respiratory epithelium in vitro.|
C Steinfort, R Wilson, T Mitchell, C Feldman, A Rutman, H Todd, D Sykes, ...
Infection and immunity 57 (7), 2006-2013, 1989
|Pneumolysin, the thiol-activated toxin of Streptococcus pneumoniae, does not require a thiol group for in vitro activity.|
FK Saunders, TJ Mitchell, JA Walker, PW Andrew, GJ Boulnois
Infection and immunity 57 (8), 2547-2552, 1989