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Amine Sadok
Amine Sadok
Sr. Director-Head of Discovery Technologies at Monte Rosa Therapeutics
Verified email at monterosatx.com
Title
Cited by
Cited by
Year
Rho GTPases: masters of cell migration
A Sadok, CJ Marshall
Small GTPases 5 (4), e983878, 2014
2562014
A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes
Z Yin, A Sadok, H Sailem, A McCarthy, X Xia, F Li, MA Garcia, L Evans, ...
Nature cell biology 15 (7), 860-871, 2013
1972013
Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis
S Kümper, FK Mardakheh, A McCarthy, M Yeo, GW Stamp, A Paul, ...
elife 5, e12203, 2016
1602016
An ezrin-rich, rigid uropod-like structure directs movement of amoeboid blebbing cells
A Lorentzen, J Bamber, A Sadok, I Elson-Schwab, CJ Marshall
Journal of cell science 124 (8), 1256-1267, 2011
1552011
Rho kinase inhibitors block melanoma cell migration and inhibit metastasis
A Sadok, A McCarthy, J Caldwell, I Collins, MD Garrett, M Yeo, S Hooper, ...
Cancer research 75 (11), 2272-2284, 2015
1462015
A strategy for high-level expression of soluble and functional human interferon α as a GST-fusion protein in E.coli
I Rabhi-Essafi, A Sadok, N Khalaf, DM Fathallah
Protein Engineering, Design & Selection 20 (5), 201-209, 2007
1332007
Global analysis of mRNA, translation, and protein localization: local translation is a key regulator of cell protrusions
FK Mardakheh, A Paul, S Kümper, A Sadok, H Paterson, A Mccarthy, ...
Developmental cell 35 (3), 344-357, 2015
1182015
Nox1-dependent superoxide production controls colon adenocarcinoma cell migration
A Sadok, V Bourgarel-Rey, F Gattacceca, C Penel, M Lehmann, ...
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1783 (1), 23-33, 2008
1162008
Modulation of cellular redox state underlies antagonism between oxaliplatin and cetuximab in human colorectal cancer cell lines
L Dahan, A Sadok, JL Formento, JF Seitz, H Kovacic
British journal of pharmacology 158 (2), 610-620, 2009
1132009
Myosin II reactivation and cytoskeletal remodeling as a hallmark and a vulnerability in melanoma therapy resistance
JL Orgaz, E Crosas-Molist, A Sadok, A Perdrix-Rosell, O Maiques, ...
Cancer Cell 37 (1), 85-103. e9, 2020
1102020
Protein disulfide isomerase is required for platelet-derived growth factor-induced vascular smooth muscle cell migration, Nox1 NADPH oxidase expression, and RhoGTPase activation
LA Pescatore, D Bonatto, FL Forti, A Sadok, H Kovacic, FRM Laurindo
Journal of Biological Chemistry 287 (35), 29290-29300, 2012
892012
Nox1 downstream of 12‐lipoxygenase controls cell proliferation but not cell spreading of colon cancer cells
DD de Carvalho, A Sadok, V Bourgarel‐Rey, F Gattacceca, C Penel, ...
International journal of cancer 122 (8), 1757-1764, 2008
662008
A critical evaluation of the approaches to targeted protein degradation for drug discovery
R Chopra, A Sadok, I Collins
Drug Discovery Today: Technologies 31, 5-13, 2019
512019
NADPH oxidase 1 controls the persistence of directed cell migration by a Rho-dependent switch of α2/α3 integrins
A Sadok, A Pierres, L Dahan, C Prévôt, M Lehmann, H Kovacic
Molecular and cellular biology 29 (14), 3915-3928, 2009
422009
Rapid patterning of 1-D collagenous topography as an ECM protein fibril platform for image cytometry
N Xue, X Li, C Bertulli, Z Li, A Patharagulpong, A Sadok, YYS Huang
PLoS One 9 (4), e93590, 2014
342014
Apolar and polar transitions drive the conversion between amoeboid and mesenchymal shapes in melanoma cells
S Cooper, A Sadok, V Bousgouni, C Bakal
Molecular biology of the cell 26 (22), 4163-4170, 2015
322015
Dynamics of filopodium-like protrusion and endothelial cellular motility on one-dimensional extracellular matrix fibrils
N Xue, C Bertulli, A Sadok, YYS Huang
Interface Focus 4 (2), 20130060, 2014
172014
Rho GTPases: masters of cell migration. Small GTPases 2014; 5: e29710; PMID: 24978113
A Sadok, CJ Marshall
6
A Degron Blocking Strategy Towards Improved CRL4CRBN Recruiting PROTAC Selectivity**
H Bouguenina, A Scarpino, JA O'Hanlon, J Warne, HZ Wang, ...
ChemBioChem 24 (23), e202300351, 2023
32023
Abstract LBA004: Identification of GSPT1-directed molecular glue degrader (MGD) for the treatment of Myc-driven breast cancer
G Gavory, B Fasching, D Bonenfant, A Sadok, A Singh, M Schillo, ...
Molecular Cancer Therapeutics 20 (12_Supplement), LBA004-LBA004, 2021
32021
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