Title
Authors
Blerina Kola, Márta Korbonits, Salvador Diaz‐Cano, Gregory Kaltsas, Damian G Morris, Suzanne Jordan, Lou Metherell, Michael Powell, Sándor Czirják, Giorgio Arnaldi, Stephen Bustin, Marco Boscaro, Franco Mantero, Ashley B Grossman
Publication date
2003/9/1
Journal name
Clinical endocrinology
Volume
59
Issue
3
Pages
328-338
Publisher
Blackwell Science Ltd
Description
objective Clinical acromegaly is characterized by elevated GH secretion in the presence of
high circulating IGF-I levels. We hypothesized that the physiological IGF-I/GH negative
feedback loop may be reset in somatotroph adenomas, specifically in terms of the level of
expression of these receptors or mutations of the GH receptor (GH-R) in such tumours.
methods We therefore investigated the full coding sequence of the GH-R in a series of
somatotroph and other pituitary adenomas. We also investigated the mRNA expression of ...
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