Authors
Lucia Pozo-Garcia, Salvador J Diaz-Cano
Publication date
2003/1
Journal
The American journal of pathology
Volume
162
Issue
1
Pages
353
Publisher
American Society for Investigative Pathology
Description
Microsatellite-based clonality assays include the analysis of X-chromosome inactivation
(XCI) and loss of heterozygosity (LOH) of tumor suppressor genes, and have been rarely
applied to differentiate clonal origin from clonal expansion in neoplasms. The key elements
for that distinction are: tumor natural history with particular attention to the relative timing
between test conversion and clonal expansion, the lesion cell kinetic, and sample
conditions. Studies based on allele ratio of genes involved in the transformation pathway ...
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