Title
Authors
Michael Koch, Manuel de Miguel, Heinz Höfler, Salvador J Diaz-Cano
Publication date
2000/5/1
Journal name
Virchows Archiv
Volume
436
Issue
5
Pages
413-420
Publisher
Springer-Verlag
Description
Abstract The cell kinetic of prostatic intraepithelial neoplasia (PIN) is poorly understood.
Herein we report the kinetic pattern of PIN, both not associated (primary) and associated
(secondary) with coexistent invasive carcinoma (PCa). Surgical specimens collected in 20
cases of primary PIN, 20 of secondary PIN and 20 of PCa were studied by MIB-1
immunostaining, in situ end-labeling (ISEL) and DNA histogram analysis, and the cell
density in each case was estimated using the formula N=(n π/4) 2. Fifty high-power fields ( ...
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