Authors
Salvador J Diaz-Cano, Alfredo Blanes, Javier Rubio, Alfredo Matilla, Hubert J Wolfe
Publication date
2000/3/1
Journal
Laboratory investigation
Volume
80
Issue
3
Pages
279-289
Publisher
Nature Publishing Group
Description
Abstract Superficial transitional cell carcinomas (TCC) of the urinary bladder have been
shown to be monoclonal. However, no combined study of clonality and tumor suppressor
genes (TSG) is available to date for muscle-invasive TCC. Forty-four muscle-invasive TCC of
the urinary bladder selected from women were included in this study. Tumor cells located
above and below the muscularis mucosa zone were systematically microdissected and used
for DNA extraction. Hha-I digested and undigested samples were used to study the ...
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