Authors
Salvador J Díaz-Cano, Manuel de Miguel, Alfredo Blanes, Robert Tashjian, Hugo Galera, Hubert J Wolfe
Publication date
2000/1/31
Journal
The American journal of pathology
Volume
156
Issue
1
Pages
311-319
Publisher
Elsevier
Description
Although histopathologic criteria for adrenal cortical nodular hyperplasias (ACNHs) and
adenomas (ACAs) have been developed, their kinetics and clonality are virtually unknown.
We studied 20 ACNHs and 25 ACAs (based on World Health Organization criteria) from 45
females. Representative samples were histologically evaluated, and the methylation pattern
of the androgen receptor alleles was analyzed on microdissected samples. Consecutive
sections were selected for slide cytometry, flow cytometry, and in situ end labeling (ISEL). ...
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