Authors
Steen Ethelberg, Barbara D Tzschaschel, Arne Luz, Salvador J Diaz-Cano, Finn Skou Pedersen, Jörg Schmidt
Publication date
1999/12/1
Journal
Journal of virology
Volume
73
Issue
12
Pages
10406-10415
Publisher
American Society for Microbiology
Description
ABSTRACT SL3-3 is a murine leukemia virus which is only weakly bone pathogenic but
highly T-cell lymphomagenic. A major pathogenic determinant is the transcriptional
enhancer comprising several transcription factor binding sites, among which are three
identical sites for nuclear factor 1 (NF1). We have investigated the pathogenic properties of
NF1 site enhancer mutants of SL3-3. Two different mutants carrying a 3-bp mutation either in
all three NF1 sites or in the central site alone were constructed and assayed in inbred ...
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