Patrick GA Pedrioli, Jimmy K Eng, Robert Hubley, Mathijs Vogelzang, Eric W Deutsch, Brian Raught, Brian Pratt, Erik Nilsson, Ruth H Angeletti, Rolf Apweiler, Kei Cheung, Catherine E Costello, Henning Hermjakob, Sequin Huang, Randall K Julian, Eugene Kapp, Mark E McComb, Stephen G Oliver, Gilbert Omenn, Norman W Paton, Richard Simpson, Richard Smith, Chris F Taylor, Weimin Zhu, Ruedi Aebersold

2004/11/1

Nature biotechnology

22

11

1459-1466

Nature Publishing Group

Abstract A broad range of mass spectrometers are used in mass spectrometry (MS)-based
proteomics research. Each type of instrument possesses a unique design, data system and
performance specifications, resulting in strengths and weaknesses for different types of
experiments. Unfortunately, the native binary data formats produced by each type of mass
spectrometer also differ and are usually proprietary. The diverse, nontransparent nature of
the data structure complicates the integration of new instruments into preexisting ...