| Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA A Szwagierczak, S Bultmann, CS Schmidt, F Spada, H Leonhardt Nucleic acids research 38 (19), e181-e181, 2010 | 518 | 2010 |
| Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA T Pfaffeneder, F Spada, M Wagner, C Brandmayr, SK Laube, D Eisen, ... Nature chemical biology 10 (7), 574-581, 2014 | 325 | 2014 |
| Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers S Bultmann, R Morbitzer, CS Schmidt, K Thanisch, F Spada, J Elsaesser, ... Nucleic acids research 40 (12), 5368-5377, 2012 | 298 | 2012 |
| Dynamics of Dnmt1 interaction with the replication machinery and its role in postreplicative maintenance of DNA methylation L Schermelleh, A Haemmer, F Spada, N Rösing, D Meilinger, ... Nucleic acids research 35 (13), 4301-4312, 2007 | 283 | 2007 |
| DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination W Qin, P Wolf, N Liu, S Link, M Smets, FL Mastra, I Forné, G Pichler, ... Cell research 25 (8), 911-929, 2015 | 259 | 2015 |
| DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells F Spada, A Haemmer, D Kuch, U Rothbauer, L Schermelleh, E Kremmer, ... The Journal of cell biology 176 (5), 565-571, 2007 | 231 | 2007 |
| Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells D Meilinger, K Fellinger, S Bultmann, U Rothbauer, IM Bonapace, ... EMBO reports 10 (11), 1259-1264, 2009 | 226 | 2009 |
| The multi-domain protein Np95 connects DNA methylation and histone modification A Rottach, C Frauer, G Pichler, IM Bonapace, F Spada, H Leonhardt Nucleic acids research 38 (6), 1796-1804, 2010 | 177 | 2010 |
| Trapped in action: direct visualization of DNA methyltransferase activity in living cells L Schermelleh, F Spada, HP Easwaran, K Zolghadr, JB Margot, ... Nature methods 2 (10), 751-756, 2005 | 177 | 2005 |
| Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1 W Qin, H Leonhardt, F Spada Journal of cellular biochemistry 112 (2), 439-444, 2011 | 171 | 2011 |
| High mobility group 1 protein is not stably associated with the chromosomes of somatic cells L Falciola, F Spada, S Calogero, G Längst, R Voit, I Grummt, ME Bianchi The Journal of cell biology 137 (1), 19-26, 1997 | 165 | 1997 |
| DNA methylation‐mediated epigenetic control A Rottach, H Leonhardt, F Spada Journal of cellular biochemistry 108 (1), 43-51, 2009 | 154 | 2009 |
| Different binding properties and function of CXXC zinc finger domains in Dnmt1 and Tet1 C Frauer, A Rottach, D Meilinger, S Bultmann, K Fellinger, S Hasenöder, ... PloS one 6 (2), e16627, 2011 | 139 | 2011 |
| Quantitative LC–MS Provides No Evidence for m6dA or m4dC in the Genome of Mouse Embryonic Stem Cells and Tissues S Schiffers, C Ebert, R Rahimoff, O Kosmatchev, J Steinbacher, AV Bohne, ... Angewandte Chemie International Edition 56 (37), 11268-11271, 2017 | 128 | 2017 |
| Non‐canonical bases in the genome: the regulatory information layer in DNA T Carell, MQ Kurz, M Müller, M Rossa, F Spada Angewandte Chemie International Edition 57 (16), 4296-4312, 2018 | 107 | 2018 |
| 5-Formylcytosine to cytosine conversion by C–C bond cleavage in vivo K Iwan, R Rahimoff, A Kirchner, F Spada, AS Schröder, O Kosmatchev, ... Nature chemical biology 14 (1), 72-78, 2018 | 95 | 2018 |
| Inactivation of the zebrafish homologue of Chx10 by antisense oligonucleotides causes eye malformations similar to the ocular retardation phenotype SML Barabino, F Spada, F Cotelli, E Boncinelli Mechanisms of development 63 (2), 133-143, 1997 | 95 | 1997 |
| The PHD domain of Np95 (mUHRF1) is involved in large-scale reorganization of pericentromeric heterochromatin R Papait, C Pistore, U Grazini, F Babbio, S Cogliati, D Pecoraro, L Brino, ... Molecular biology of the cell 19 (8), 3554-3563, 2008 | 79 | 2008 |
| Cell‐Penetrating and Neurotargeting Dendritic siRNA Nanostructures K Brunner, J Harder, T Halbach, J Willibald, F Spada, F Gnerlich, ... Angewandte Chemie International Edition 54 (6), 1946-1949, 2015 | 70 | 2015 |
| Characterization of PvuRts1I endonuclease as a tool to investigate genomic 5–hydroxymethylcytosine A Szwagierczak, A Brachmann, CS Schmidt, S Bultmann, H Leonhardt, ... Nucleic acids research 39 (12), 5149-5156, 2011 | 69 | 2011 |
