Christopher G Tate
Christopher G Tate
Programme Leader, MRC Laboratory of Molecular Biology, Cambridge
Verified email at
Cited by
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Structure of a β1-adrenergic G-protein-coupled receptor
T Warne, MJ Serrano-Vega, JG Baker, R Moukhametzianov, PC Edwards, ...
Nature 454 (7203), 486-491, 2008
Molecular signatures of G-protein-coupled receptors
AJ Venkatakrishnan, X Deupi, G Lebon, CG Tate, GF Schertler, MM Babu
Nature 494 (7436), 185-194, 2013
Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation
G Lebon, T Warne, PC Edwards, K Bennett, CJ Langmead, AGW Leslie, ...
Nature 474 (7352), 521-525, 2011
The structural basis for agonist and partial agonist action on a β1-adrenergic receptor
T Warne, R Moukhametzianov, JG Baker, R Nehmé, PC Edwards, ...
Nature 469 (7329), 241-244, 2011
Structure of the adenosine A2A receptor in complex with ZM241385 and the xanthines XAC and caffeine
AS Doré, N Robertson, JC Errey, I Ng, K Hollenstein, B Tehan, E Hurrell, ...
Structure 19 (9), 1283-1293, 2011
Structure of the agonist-bound neurotensin receptor
JF White, N Noinaj, Y Shibata, J Love, B Kloss, F Xu, ...
Nature 490 (7421), 508-513, 2012
Conformational thermostabilization of the β1-adrenergic receptor in a detergent-resistant form
MJ Serrano-Vega, F Magnani, Y Shibata, CG Tate
Proceedings of the National Academy of Sciences 105 (3), 877-882, 2008
Overcoming barriers to membrane protein structure determination
RM Bill, PJF Henderson, S Iwata, ERS Kunji, H Michel, R Neutze, ...
Nature biotechnology 29 (4), 335-340, 2011
Structure of the adenosine A2A receptor bound to an engineered G protein
B Carpenter, R Nehmé, T Warne, AGW Leslie, CG Tate
Nature 536 (7614), 104-107, 2016
Universal allosteric mechanism for Gα activation by GPCRs
T Flock, CNJ Ravarani, D Sun, AJ Venkatakrishnan, M Kayikci, CG Tate, ...
Nature 524 (7564), 173-179, 2015
Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region
AJ Venkatakrishnan, X Deupi, G Lebon, FM Heydenreich, T Flock, ...
Nature 536 (7617), 484-487, 2016
Overexpression of mammalian integral membrane proteins for structural studies
CG Tate
FEBS letters 504 (3), 94-98, 2001
Co-evolving stability and conformational homogeneity of the human adenosine A2a receptor
F Magnani, Y Shibata, MJ Serrano-Vega, CG Tate
Proceedings of the National Academy of Sciences 105 (31), 10744-10749, 2008
Impact of GPCR structures on drug discovery
M Congreve, C de Graaf, NA Swain, CG Tate
Cell 181 (1), 81-91, 2020
Mini G protein probes for active G protein–coupled receptors (GPCRs) in live cells
Q Wan, N Okashah, A Inoue, R Nehmé, B Carpenter, CG Tate, ...
Journal of Biological Chemistry 293 (19), 7466-7473, 2018
Crystal structures of a stabilized β1-adrenoceptor bound to the biased agonists bucindolol and carvedilol
T Warne, PC Edwards, AGW Leslie, CG Tate
Structure 20 (5), 841-849, 2012
PtdIns (4, 5) P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling
HY Yen, KK Hoi, I Liko, G Hedger, MR Horrell, W Song, D Wu, P Heine, ...
Nature 559 (7714), 423-427, 2018
Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein
J García-Nafría, Y Lee, X Bai, B Carpenter, CG Tate
elife 7, e35946, 2018
Three-dimensional structure of the bacterial multidrug transporter EmrE shows it is an asymmetric homodimer
I Ubarretxena-Belandia, JM Baldwin, S Schuldiner, CG Tate
The EMBO journal 22 (23), 6175-6181, 2003
Two distinct conformations of helix 6 observed in antagonist-bound structures of a β1-adrenergic receptor
R Moukhametzianov, T Warne, PC Edwards, MJ Serrano-Vega, ...
Proceedings of the National Academy of Sciences 108 (20), 8228-8232, 2011
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