Leonid Breydo
Leonid Breydo
Staff Scientist, Regeneron
Verified email at
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Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers
R Kayed, E Head, F Sarsoza, T Saing, CW Cotman, M Necula, L Margol, ...
Molecular neurodegeneration 2 (1), 1-11, 2007
α-Synuclein misfolding and Parkinson's disease
L Breydo, JW Wu, VN Uversky
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1822 (2), 261-285, 2012
Antiparallel β-sheet: a signature structure of the oligomeric amyloid β-peptide
E Cerf, R Sarroukh, S Tamamizu-Kato, L Breydo, S Derclaye, YF Dufrêne, ...
Biochemical Journal 421 (3), 415-423, 2009
In vitro conversion of full-length mammalian prion protein produces amyloid form with physical properties of PrPSc
OV Bocharova, L Breydo, AS Parfenov, VV Salnikov, IV Baskakov
Journal of molecular biology 346 (2), 645-659, 2005
Accelerated neurodegeneration through chaperone-mediated oligomerization of tau
LJ Blair, BA Nordhues, SE Hill, KM Scaglione, JC O’Leary, SN Fontaine, ...
The Journal of clinical investigation 123 (10), 4158-4169, 2013
Methylene blue inhibits amyloid Aβ oligomerization by promoting fibrillization
M Necula, L Breydo, S Milton, R Kayed, WE Van Der Veer, P Tone, ...
Biochemistry 46 (30), 8850-8860, 2007
Copper (II) inhibits in vitro conversion of prion protein into amyloid fibrils
OV Bocharova, L Breydo, VV Salnikov, IV Baskakov
Biochemistry 44 (18), 6776-6787, 2005
Beyond the excluded volume effects: mechanistic complexity of the crowded milieu
IM Kuznetsova, BY Zaslavsky, L Breydo, KK Turoverov, VN Uversky
Molecules 20 (1), 1377-1409, 2015
Structural, morphological, and functional diversity of amyloid oligomers
L Breydo, VN Uversky
FEBS letters 589 (19), 2640-2648, 2015
Fibrillar oligomers nucleate the oligomerization of monomeric amyloid β but do not seed fibril formation
JW Wu, L Breydo, JM Isas, J Lee, YG Kuznetsov, R Langen, C Glabe
Journal of Biological Chemistry 285 (9), 6071-6079, 2010
Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers
R Kayed, I Canto, L Breydo, S Rasool, T Lukacsovich, J Wu, R Albay, ...
Molecular neurodegeneration 5, 1-10, 2010
Polymorphism and ultrastructural organization of prion protein amyloid fibrils: an insight from high resolution atomic force microscopy
M Anderson, OV Bocharova, N Makarava, L Breydo, VV Salnikov, ...
Journal of molecular biology 358 (2), 580-596, 2006
Role of metal ions in aggregation of intrinsically disordered proteins in neurodegenerative diseases
L Breydo, VN Uversky
Metallomics 3 (11), 1163-1180, 2011
Intracellular processing of disease-associated α-synuclein in the human brain suggests prion-like cell-to-cell spread
GG Kovacs, L Breydo, R Green, V Kis, G Puska, P Lőrincz, ...
Neurobiology of disease 69, 76-92, 2014
Chemoenzymatic Synthesis of HIV-1 V3 Glycopeptides Carrying Two N-Glycans and Effects of Glycosylation on the Peptide Domain
H Li, B Li, H Song, L Breydo, IV Baskakov, LX Wang
The Journal of organic chemistry 70 (24), 9990-9996, 2005
Synthetic prions generated in vitro are similar to a newly identified subpopulation of PrPSc from sporadic Creutzfeldt‐Jakob Disease
OV Bocharova, L Breydo, VV Salnikov, AC Gill, IV Baskakov
Protein science 14 (5), 1222-1232, 2005
Methionine oxidation interferes with conversion of the prion protein into the fibrillar proteinase K-resistant conformation
L Breydo, OV Bocharova, N Makarava, VV Salnikov, M Anderson, ...
Biochemistry 44 (47), 15534-15543, 2005
The crowd you're in with: effects of different types of crowding agents on protein aggregation
L Breydo, KD Reddy, A Piai, IC Felli, R Pierattelli, VN Uversky
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1844 (2), 346-357, 2013
Structural differences between amyloid beta oligomers
L Breydo, D Kurouski, S Rasool, S Milton, JW Wu, VN Uversky, IK Lednev, ...
Biochemical and biophysical research communications 477 (4), 700-705, 2016
Annealing prion protein amyloid fibrils at high temperature results in extension of a proteinase K-resistant core
OV Bocharova, N Makarava, L Breydo, M Anderson, VV Salnikov, ...
Journal of Biological Chemistry 281 (4), 2373-2379, 2006
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