Genome sequence of the human malaria parasite Plasmodium falciparum MJ Gardner, N Hall, E Fung, O White, M Berriman, RW Hyman, JM Carlton, ... Nature 419 (6906), 498-511, 2002 | 5528 | 2002 |
Drug resistance in leishmaniasis SL Croft, S Sundar, AH Fairlamb Clinical microbiology reviews 19 (1), 111-126, 2006 | 2150 | 2006 |
The Genome of the African Trypanosome Trypanosoma brucei M Berriman, E Ghedin, C Hertz-Fowler, G Blandin, H Renauld, ... science 309 (5733), 416-422, 2005 | 2017 | 2005 |
Metabolism and functions of trypanothione in the Kinetoplastida AH Fairlamb, A Cerami Annual review of microbiology 46 (1), 695-729, 1992 | 996 | 1992 |
Trypanothione: a novel bis (glutathionyl) spermidine cofactor for glutathione reductase in trypanosomatids AH Fairlamb, P Blackburn, P Ulrich, BT Chait, A Cerami Science 227 (4693), 1485-1487, 1985 | 855 | 1985 |
Kinetoplastids: related protozoan pathogens, different diseases K Stuart, R Brun, S Croft, A Fairlamb, RE Gürtler, J McKerrow, S Reed, ... The Journal of clinical investigation 118 (4), 1301-1310, 2008 | 745 | 2008 |
Chemotherapy of human African trypanosomiasis: current and future prospects AH Fairlamb Trends in parasitology 19 (11), 488-494, 2003 | 471 | 2003 |
A novel multiple-stage antimalarial agent that inhibits protein synthesis B Baragaña, I Hallyburton, MCS Lee, NR Norcross, R Grimaldi, TD Otto, ... Nature 522 (7556), 315-320, 2015 | 462 | 2015 |
Arsenical-resistant trypanosomes lack an unusual adenosine transporter NS Carter, AH Fairlamb Nature 361 (6408), 173-176, 1993 | 456 | 1993 |
Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress S Krieger, W Schwarz, MR Ariyanayagam, AH Fairlamb, ... Molecular microbiology 35 (3), 542-552, 2000 | 433 | 2000 |
Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need MC Field, D Horn, AH Fairlamb, MAJ Ferguson, DW Gray, KD Read, ... Nature Reviews Microbiology 15 (4), 217-231, 2017 | 422 | 2017 |
Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani S Wyllie, ML Cunningham, AH Fairlamb Journal of Biological Chemistry 279 (38), 39925-39932, 2004 | 416 | 2004 |
Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages C Dumas, M Ouellette, J Tovar, ML Cunningham, AH Fairlamb, S Tamar, ... The EMBO journal, 1997 | 398 | 1997 |
Purification and characterization of trypanothione reductase from Crithidia fasciculata, a new member of the family of disulfide-containing flavoprotein reductases SL Shames, AH Fairlamb, A Cerami, CT Walsh Biochemistry 25 (12), 3519-3526, 1986 | 343 | 1986 |
N-myristoyltransferase inhibitors as new leads to treat sleeping sickness JA Frearson, S Brand, SP McElroy, LAT Cleghorn, O Smid, L Stojanovski, ... Nature 464 (7289), 728-732, 2010 | 324 | 2010 |
Trypanothione is the primary target for arsenical drugs against African trypanosomes. AH Fairlamb, GB Henderson, A Cerami Proceedings of the National Academy of Sciences 86 (8), 2607-2611, 1989 | 285 | 1989 |
Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells J Aliberti, JG Valenzuela, VB Carruthers, S Hieny, J Andersen, H Charest, ... Nature immunology 4 (5), 485-490, 2003 | 270 | 2003 |
Uptake of diamidine drugs by the P2 nucleoside transporter in melarsen-sensitive and-resistant Trypanosoma brucei brucei NS Carter, BJ Berger, AH Fairlamb Journal of Biological Chemistry 270 (47), 28153-28157, 1995 | 270 | 1995 |
" Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease. GB Henderson, P Ulrich, AH Fairlamb, I Rosenberg, M Pereira, M Sela, ... Proceedings of the National Academy of Sciences 85 (15), 5374-5378, 1988 | 253 | 1988 |
Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors CS Bond, Y Zhang, M Berriman, ML Cunningham, AH Fairlamb, ... Structure 7 (1), 81-89, 1999 | 252 | 1999 |