Follow
Jian Jin
Jian Jin
Professor, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
Verified email at mssm.edu
Title
Cited by
Cited by
Year
The promise and peril of chemical probes
CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ...
Nature chemical biology 11 (8), 536-541, 2015
8392015
Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer
JS Duncan, MC Whittle, K Nakamura, AN Abell, AA Midland, ...
Cell 149 (2), 307-321, 2012
8342012
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
M Vedadi, D Barsyte-Lovejoy, F Liu, S Rival-Gervier, A Allali-Hassani, ...
Nature chemical biology 7 (8), 566-574, 2011
5592011
An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1
KD Konze, A Ma, F Li, D Barsyte-Lovejoy, T Parton, CJ MacNevin, F Liu, ...
ACS chemical biology 8 (6), 1324-1334, 2013
4842013
Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons
HS Huang, JA Allen, AM Mabb, IF King, J Miriyala, B Taylor-Blake, ...
Nature 481 (7380), 185-189, 2012
3972012
Discovery of β-arrestin–biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy
JA Allen, JM Yost, V Setola, X Chen, MF Sassano, M Chen, S Peterson, ...
Proceedings of the National Academy of Sciences 108 (45), 18488-18493, 2011
3832011
Inhibition of lapatinib-induced kinome reprogramming in ERBB2-positive breast cancer by targeting BET family bromodomains
TJ Stuhlmiller, SM Miller, JS Zawistowski, K Nakamura, AS Beltran, ...
Cell reports 11 (3), 390-404, 2015
3362015
Advancing targeted protein degradation for cancer therapy
B Dale, M Cheng, KS Park, HÜ Kaniskan, Y Xiong, J Jin
Nature Reviews Cancer 21 (10), 638-654, 2021
3142021
Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP
F Liu, D Barsyte-Lovejoy, F Li, Y Xiong, V Korboukh, XP Huang, ...
Journal of medicinal chemistry 56 (21), 8931-8942, 2013
2752013
Inhibitors of protein methyltransferases and demethylases
HU Kaniskan, ML Martini, J Jin
Chemical reviews 118 (3), 989-1068, 2018
2742018
Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65
XP Huang, J Karpiak, WK Kroeze, H Zhu, X Chen, SS Moy, KA Saddoris, ...
Nature 527 (7579), 477-483, 2015
2612015
Structure and inhibition of microbiome β-glucuronidases essential to the alleviation of cancer drug toxicity
BD Wallace, AB Roberts, RM Pollet, JD Ingle, KA Biernat, SJ Pellock, ...
Chemistry & biology 22 (9), 1238-1249, 2015
2612015
In silico design of novel probes for the atypical opioid receptor MRGPRX2
K Lansu, J Karpiak, J Liu, XP Huang, JD McCorvy, WK Kroeze, T Che, ...
Nature chemical biology 13 (5), 529-536, 2017
2592017
Discovery of a 2, 4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a
F Liu, X Chen, A Allali-Hassani, AM Quinn, GA Wasney, A Dong, ...
Journal of medicinal chemistry 52 (24), 7950-7953, 2009
2502009
Light-induced control of protein destruction by opto-PROTAC
J Liu, H Chen, L Ma, Z He, D Wang, Y Liu, Q Lin, T Zhang, N Gray, ...
Science advances 6 (8), eaay5154, 2020
2472020
Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys
Y Nagai, N Miyakawa, H Takuwa, Y Hori, K Oyama, B Ji, M Takahashi, ...
Nature neuroscience 23 (9), 1157-1167, 2020
2462020
A potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases
MS Eram, Y Shen, MM Szewczyk, H Wu, G Senisterra, F Li, KV Butler, ...
ACS chemical biology 11 (3), 772-781, 2016
2442016
First Chelated Chiral N-Heterocyclic Bis-Carbene Complexes
DS Clyne, J Jin, E Genest, JC Gallucci, TV RajanBabu
Organic Letters 2 (8), 1125-1128, 2000
2432000
Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia
B Xu, DM On, A Ma, T Parton, KD Konze, SG Pattenden, DF Allison, L Cai, ...
Blood, The Journal of the American Society of Hematology 125 (2), 346-357, 2015
2362015
Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2, 4-diamino-7-aminoalkoxy-quinazolines.
F Liu, X Chen, A Allali-Hassani, AM Quinn, TJ Wigle, GA Wasney, A Dong, ...
Journal of medicinal chemistry 53 (15), 5844-5857, 2010
2232010
The system can't perform the operation now. Try again later.
Articles 1–20