Jian Jin
Jian Jin
Professor, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
Verified email at mssm.edu
Title
Cited by
Cited by
Year
Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer
JS Duncan, MC Whittle, K Nakamura, AN Abell, AA Midland, ...
Cell 149 (2), 307-321, 2012
6652012
The promise and peril of chemical probes
CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ...
Nature chemical biology 11 (8), 536-541, 2015
5542015
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
M Vedadi, D Barsyte-Lovejoy, F Liu, S Rival-Gervier, A Allali-Hassani, ...
Nature chemical biology 7 (8), 566-574, 2011
4522011
An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1
KD Konze, A Ma, F Li, D Barsyte-Lovejoy, T Parton, CJ MacNevin, F Liu, ...
ACS chemical biology 8 (6), 1324-1334, 2013
3492013
Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons
HS Huang, JA Allen, AM Mabb, IF King, J Miriyala, B Taylor-Blake, ...
Nature 481 (7380), 185-189, 2012
3162012
Discovery of β-arrestin–biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy
JA Allen, JM Yost, V Setola, X Chen, MF Sassano, M Chen, S Peterson, ...
Proceedings of the National Academy of Sciences 108 (45), 18488-18493, 2011
3022011
Inhibition of lapatinib-induced kinome reprogramming in ERBB2-positive breast cancer by targeting BET family bromodomains
TJ Stuhlmiller, SM Miller, JS Zawistowski, K Nakamura, AS Beltran, ...
Cell reports 11 (3), 390-404, 2015
2412015
First Chelated Chiral N-Heterocyclic Bis-Carbene Complexes
DS Clyne, J Jin, E Genest, JC Gallucci, TV RajanBabu
Organic letters 2 (8), 1125-1128, 2000
2312000
Discovery of a 2, 4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a
F Liu, X Chen, A Allali-Hassani, AM Quinn, GA Wasney, A Dong, ...
Journal of medicinal chemistry 52 (24), 7950-7953, 2009
2062009
Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2, 4-diamino-7-aminoalkoxy-quinazolines.
F Liu, X Chen, A Allali-Hassani, AM Quinn, TJ Wigle, GA Wasney, A Dong, ...
Journal of medicinal chemistry 53 (15), 5844-5857, 2010
1872010
Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP
F Liu, D Barsyte-Lovejoy, F Li, Y Xiong, V Korboukh, XP Huang, ...
Journal of medicinal chemistry 56 (21), 8931-8942, 2013
1732013
Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia
B Xu, DM On, A Ma, T Parton, KD Konze, SG Pattenden, DF Allison, L Cai, ...
Blood 125 (2), 346-357, 2015
1672015
Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition
SM Johnson, CD Torrice, JF Bell, KB Monahan, Q Jiang, Y Wang, ...
The Journal of clinical investigation 120 (7), 2528-2536, 2010
1632010
The hydrovinylation reaction: A new highly selective protocol amenable to asymmetric catalysis
N Nomura, J Jin, H Park, TV RajanBabu
Journal of the American Chemical Society 120 (2), 459-460, 1998
1541998
Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65
XP Huang, J Karpiak, WK Kroeze, H Zhu, X Chen, SS Moy, KA Saddoris, ...
Nature 527 (7579), 477-483, 2015
1522015
Structure and inhibition of microbiome β-glucuronidases essential to the alleviation of cancer drug toxicity
BD Wallace, AB Roberts, RM Pollet, JD Ingle, KA Biernat, SJ Pellock, ...
Chemistry & biology 22 (9), 1238-1249, 2015
1512015
Synergistic effects of hemilabile coordination and counterions in homogeneous catalysis: new tunable monophosphine ligands for hydrovinylation reactions
M Nandi, J Jin, TV RajanBabu
Journal of the American Chemical Society 121 (42), 9899-9900, 1999
1501999
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain
LI James, D Barsyte-Lovejoy, N Zhong, L Krichevsky, VK Korboukh, ...
Nature chemical biology 9 (3), 184-191, 2013
1482013
Combined PI3K/mTOR and MEK inhibition provides broad antitumor activity in faithful murine cancer models
PJ Roberts, JE Usary, DB Darr, PM Dillon, AD Pfefferle, MC Whittle, ...
Clinical cancer research 18 (19), 5290-5303, 2012
1472012
In silico design of novel probes for the atypical opioid receptor MRGPRX2
K Lansu, J Karpiak, J Liu, XP Huang, JD McCorvy, WK Kroeze, T Che, ...
Nature chemical biology 13 (5), 529-536, 2017
1412017
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