Jian Jin
Jian Jin
Professor, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
Verified email at mssm.edu
TitleCited byYear
Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer
JS Duncan, MC Whittle, K Nakamura, AN Abell, AA Midland, ...
Cell 149 (2), 307-321, 2012
5012012
The promise and peril of chemical probes
CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ...
Nature chemical biology 11 (8), 536, 2015
3862015
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
M Vedadi, D Barsyte-Lovejoy, F Liu, S Rival-Gervier, A Allali-Hassani, ...
Nature chemical biology 7 (8), 566, 2011
3632011
An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1
KD Konze, A Ma, F Li, D Barsyte-Lovejoy, T Parton, CJ MacNevin, F Liu, ...
ACS chemical biology 8 (6), 1324-1334, 2013
2812013
Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons
HS Huang, JA Allen, AM Mabb, IF King, J Miriyala, B Taylor-Blake, ...
Nature 481 (7380), 185, 2012
2682012
Discovery of β-arrestin–biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy
JA Allen, JM Yost, V Setola, X Chen, MF Sassano, M Chen, S Peterson, ...
Proceedings of the National Academy of Sciences 108 (45), 18488-18493, 2011
2532011
First Chelated Chiral N-Heterocyclic Bis-Carbene Complexes
DS Clyne, J Jin, E Genest, JC Gallucci, TV RajanBabu
Organic letters 2 (8), 1125-1128, 2000
2172000
Discovery of a 2, 4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a
F Liu, X Chen, A Allali-Hassani, AM Quinn, GA Wasney, A Dong, ...
Journal of medicinal chemistry 52 (24), 7950-7953, 2009
1852009
Inhibition of lapatinib-induced kinome reprogramming in ERBB2-positive breast cancer by targeting BET family bromodomains
TJ Stuhlmiller, SM Miller, JS Zawistowski, K Nakamura, AS Beltran, ...
Cell reports 11 (3), 390-404, 2015
1632015
Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2, 4-diamino-7-aminoalkoxy-quinazolines.
F Liu, X Chen, A Allali-Hassani, AM Quinn, TJ Wigle, GA Wasney, A Dong, ...
Journal of medicinal chemistry 53 (15), 5844-5857, 2010
1632010
Synergistic effects of hemilabile coordination and counterions in homogeneous catalysis: new tunable monophosphine ligands for hydrovinylation reactions
M Nandi, J Jin, TV RajanBabu
Journal of the American Chemical Society 121 (42), 9899-9900, 1999
1511999
The hydrovinylation reaction: A new highly selective protocol amenable to asymmetric catalysis
N Nomura, J Jin, H Park, TV RajanBabu
Journal of the American Chemical Society 120 (2), 459-460, 1998
1501998
Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition
SM Johnson, CD Torrice, JF Bell, KB Monahan, Q Jiang, Y Wang, ...
The Journal of clinical investigation 120 (7), 2528-2536, 2010
1382010
Combined PI3K/mTOR and MEK inhibition provides broad antitumor activity in faithful murine cancer models
PJ Roberts, JE Usary, DB Darr, PM Dillon, AD Pfefferle, MC Whittle, ...
Clinical cancer research 18 (19), 5290-5303, 2012
1262012
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain
LI James, D Barsyte-Lovejoy, N Zhong, L Krichevsky, VK Korboukh, ...
Nature chemical biology 9 (3), 184, 2013
1212013
Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia
B Xu, DM On, A Ma, T Parton, KD Konze, SG Pattenden, DF Allison, L Cai, ...
Blood 125 (2), 346-357, 2015
1202015
Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP
F Liu, D Barsyte-Lovejoy, F Li, Y Xiong, V Korboukh, XP Huang, ...
Journal of medicinal chemistry 56 (21), 8931-8942, 2013
1142013
AMP is an adenosine A1 receptor agonist
JE Rittiner, I Korboukh, EA Hull-Ryde, J Jin, WP Janzen, SV Frye, ...
Journal of Biological Chemistry 287 (8), 5301-5309, 2012
1052012
Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65
XP Huang, J Karpiak, WK Kroeze, H Zhu, X Chen, SS Moy, KA Saddoris, ...
Nature 527 (7579), 477, 2015
1022015
Small-molecule ligands of methyl-lysine binding proteins
JM Herold, TJ Wigle, JL Norris, R Lam, VK Korboukh, C Gao, ...
Journal of medicinal chemistry 54 (7), 2504-2511, 2011
1012011
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