| Cas9 specifies functional viral targets during CRISPR–Cas adaptation R Heler, P Samai, JW Modell, C Weiner, GW Goldberg, D Bikard, ... Nature 519 (7542), 199-202, 2015 | 531 | 2015 |
| A high-throughput platform to identify small-molecule inhibitors of CRISPR-Cas9 B Maji, SA Gangopadhyay, M Lee, M Shi, P Wu, R Heler, B Mok, D Lim, ... Cell 177 (4), 1067-1079. e19, 2019 | 163 | 2019 |
| Enhanced bacterial immunity and mammalian genome editing via RNA-polymerase-mediated dislodging of Cas9 from double-strand DNA breaks R Clarke, R Heler, MS MacDougall, NC Yeo, A Chavez, M Regan, ... Molecular cell 71 (1), 42-55. e8, 2018 | 140 | 2018 |
| Adapting to new threats: the generation of memory by CRISPR‐Cas immune systems R Heler, LA Marraffini, D Bikard Molecular microbiology 93 (1), 1-9, 2014 | 138 | 2014 |
| Genomes in focus: development and applications of CRISPR‐Cas9 imaging technologies SC Knight, R Tjian, JA Doudna Angewandte Chemie International Edition 57 (16), 4329-4337, 2018 | 82 | 2018 |
| Mutations in Cas9 enhance the rate of acquisition of viral spacer sequences during the CRISPR-Cas immune response R Heler, AV Wright, M Vucelja, D Bikard, JA Doudna, LA Marraffini Molecular cell 65 (1), 168-175, 2017 | 53 | 2017 |
| Spacer acquisition rates determine the immunological diversity of the type II CRISPR-Cas immune response R Heler, AV Wright, M Vucelja, JA Doudna, LA Marraffini Cell host & microbe 25 (2), 242-249. e3, 2019 | 23 | 2019 |
| Homology model and targeted mutagenesis identify critical residues for arachidonic acid inhibition of Kv4 channels R Heler, JK Bell, LM Boland Channels 7 (2), 74-84, 2013 | 12 | 2013 |
| A unique alkaline pH-regulated and fatty acid-activated tandem pore domain potassium channel (K2P) from a marine sponge GD Wells, QY Tang, R Heler, GJ Tompkins-MacDonald, EN Pritchard, ... Journal of Experimental Biology 215 (14), 2435-2444, 2012 | 11 | 2012 |
| Small-Molecule Inhibitors of CRISPR-Cas9 D Trauner, M Reynders Synfacts 15 (08), 0936, 2019 | | 2019 |
| Generation of Memory of Infection During the CRISPR-Cas9 Immune Response R Heler | | 2019 |
| David Bikard R Heler, LA Marraffini Annu Rev Biochem 82, 237-66, 2013 | | 2013 |
| Targeted Mutagenesis with a Homology Model Identifies Critical Residues for Arachidonic Acid Inhibition of Kv4 Channels LM Boland, R Heler, JA Bell Biophysical Journal 102 (3), 533a, 2012 | | 2012 |
| Identification of a Kv4 channel hydrophobic binding pocket for the inhibitory effects of polyunsaturated fatty acids R Heler, JA Bell, LM Boland Biophysical Journal 100 (3), 283a, 2011 | | 2011 |
| Supplemental Material to: Robert Heler, Jessica K. Bell and Linda M. Boland R Heler | | |
