| The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells J Wenzel, J Lampe, H Müller-Fielitz, R Schuster, M Zille, K Müller, ... Nature neuroscience 24 (11), 1522-1533, 2021 | 239 | 2021 |
| Exosomal cellular prion protein drives fibrillization of amyloid beta and counteracts amyloid beta‐mediated neurotoxicity C Falker, A Hartmann, I Guett, F Dohler, H Altmeppen, C Betzel, ... Journal of neurochemistry 137 (1), 88-100, 2016 | 168 | 2016 |
| Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions J Prox, C Bernreuther, H Altmeppen, J Grendel, M Glatzel, R D'Hooge, ... Journal of Neuroscience 33 (32), 12915-12928, 2013 | 149 | 2013 |
| LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance M Rothaug, F Zunke, JR Mazzulli, M Schweizer, H Altmeppen, ... Proceedings of the National Academy of Sciences 111 (43), 15573-15578, 2014 | 145 | 2014 |
| High molecular mass assemblies of amyloid-β oligomers bind prion protein in patients with Alzheimer’s disease F Dohler, D Sepulveda-Falla, S Krasemann, H Altmeppen, H Schlüter, ... Brain 137 (3), 873-886, 2014 | 136 | 2014 |
| Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo HC Altmeppen, J Prox, B Puig, MA Kluth, C Bernreuther, D Thurm, ... Molecular neurodegeneration 6, 1-12, 2011 | 136 | 2011 |
| Proteolytic processing of the prion protein in health and disease HC Altmeppen, B Puig, F Dohler, DK Thurm, C Falker, S Krasemann, ... American journal of neurodegenerative disease 1 (1), 15, 2012 | 131 | 2012 |
| Rapid and reliable universal cloning of influenza A virus genes by target-primed plasmid amplification J Stech, O Stech, A Herwig, H Altmeppen, J Hundt, S Gohrbandt, ... Nucleic acids research 36 (21), e139-e139, 2008 | 116 | 2008 |
| The sheddase ADAM10 is a potent modulator of prion disease HC Altmeppen, J Prox, S Krasemann, B Puig, K Kruszewski, F Dohler, ... Elife 4, e04260, 2015 | 100 | 2015 |
| Diverse functions of the prion protein–Does proteolytic processing hold the key? L Linsenmeier, HC Altmeppen, S Wetzel, B Mohammadi, P Saftig, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1864 (11), 2128-2137, 2017 | 84 | 2017 |
| Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site C Schönherr, J Bien, S Isbert, R Wichert, J Prox, H Altmeppen, S Kumar, ... Molecular neurodegeneration 11, 1-16, 2016 | 84 | 2016 |
| The GPI-anchoring of PrP: implications in sorting and pathogenesis B Puig, H Altmeppen, M Glatzel Prion 8 (1), 11-18, 2014 | 83 | 2014 |
| Activation of the Nipah virus fusion protein in MDCK cells is mediated by cathepsin B within the endosome-recycling compartment S Diederich, L Sauerhering, M Weis, H Altmeppen, N Schaschke, ... Journal of virology 86 (7), 3736-3745, 2012 | 81 | 2012 |
| Cellular composition of cerebrospinal fluid in HIV-1 infected and uninfected subjects EL Ho, R Ronquillo, H Altmeppen, SS Spudich, RW Price, E Sinclair PloS one 8 (6), e66188, 2013 | 79 | 2013 |
| Characterization of brain-derived extracellular vesicles reveals changes in cellular origin after stroke and enrichment of the prion protein with a potential role in cellular … S Brenna, HC Altmeppen, B Mohammadi, B Rissiek, F Schlink, P Ludewig, ... Journal of extracellular vesicles 9 (1), 1809065, 2020 | 67 | 2020 |
| Roles of endoproteolytic α‐cleavage and shedding of the prion protein in neurodegeneration HC Altmeppen, J Prox, B Puig, F Dohler, C Falker, S Krasemann, ... The FEBS journal 280 (18), 4338-4347, 2013 | 67 | 2013 |
| Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein L Linsenmeier, B Mohammadi, S Wetzel, B Puig, WS Jackson, ... Molecular neurodegeneration 13, 1-17, 2018 | 58 | 2018 |
| Muskelin coordinates PrPC lysosome versus exosome targeting and impacts prion disease progression FF Heisler, Y Pechmann, I Wieser, HC Altmeppen, L Veenendaal, ... Neuron 99 (6), 1155-1169. e9, 2018 | 51 | 2018 |
| GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice B Puig, HC Altmeppen, L Linsenmeier, K Chakroun, F Wegwitz, ... PLoS pathogens 15 (1), e1007520, 2019 | 48 | 2019 |
| In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15 L Seipold, H Altmeppen, T Koudelka, A Tholey, P Kasparek, R Sedlacek, ... Cellular and Molecular Life Sciences 75, 3251-3267, 2018 | 48 | 2018 |
Glatzel, MProfessor of Neuropathology Institute of Neuropathology, University Medical Center Hamburg-EppendorfVerified email at uke.de
