| The Nrf2–Keap1 defence pathway: role in protection against drug-induced toxicity IM Copple, CE Goldring, NR Kitteringham, BK Park Toxicology 246 (1), 24-33, 2008 | 397 | 2008 |
| Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway IM Copple, A Lister, AD Obeng, NR Kitteringham, RE Jenkins, R Layfield, ... Journal of Biological Chemistry 285 (22), 16782-16788, 2010 | 298 | 2010 |
| Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy A Lister, T Nedjadi, NR Kitteringham, F Campbell, E Costello, B Lloyd, ... Molecular cancer 10 (1), 37, 2011 | 296 | 2011 |
| Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2 A Olayanju, IM Copple, HK Bryan, GT Edge, RL Sison, MW Wong, ZQ Lai, ... Free Radical Biology and Medicine 78, 202-212, 2015 | 234 | 2015 |
| Role of Nrf2 in protection against acute kidney injury LM Shelton, BK Park, IM Copple Kidney international 84 (6), 1090-1095, 2013 | 218 | 2013 |
| Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models RJ Weaver, EA Blomme, AE Chadwick, IM Copple, HHJ Gerets, ... Nature Reviews Drug Discovery 19 (2), 131-148, 2020 | 211 | 2020 |
| The Keap1–Nrf2 cell defense pathway–a promising therapeutic target? IM Copple Advances in pharmacology 63, 43-79, 2012 | 199 | 2012 |
| The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials AE Mercer, IM Copple, JL Maggs, PM O'Neill, BK Park Journal of Biological Chemistry 286 (2), 987-996, 2011 | 193 | 2011 |
| The hepatotoxic metabolite of acetaminophen directly activates the Keap1‐Nrf2 cell defense system IM Copple, CE Goldring, RE Jenkins, AJL Chia, LE Randle, JD Hayes, ... Hepatology 48 (4), 1292-1301, 2008 | 175 | 2008 |
| The keap1-nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity IM Copple, CE Goldring, NR Kitteringham, BK Park Adverse Drug Reactions, 233-266, 2010 | 120 | 2010 |
| Advances and challenges in therapeutic targeting of NRF2 AT Dinkova-Kostova, IM Copple Trends in pharmacological sciences 44 (3), 137-149, 2023 | 111 | 2023 |
| Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications J Walsh, RE Jenkins, M Wong, A Olayanju, H Powell, I Copple, PM O’Neill, ... Journal of proteomics 108, 171-187, 2014 | 77 | 2014 |
| A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance PM O’Neill, RK Amewu, SA Charman, S Sabbani, NF Gnädig, J Straimer, ... Nature Communications 8 (1), 15159, 2017 | 71 | 2017 |
| Extract of Ginkgo biloba induces phase 2 genes through Keap1-Nrf2-ARE signaling pathway XP Liu, CEP Goldring, IM Copple, HY Wang, W Wei, NR Kitteringham, ... Life sciences 80 (17), 1586-1591, 2007 | 61 | 2007 |
| Value of monitoring Nrf2 activity for the detection of chemical and oxidative stress FE Mutter, BK Park, IM Copple Biochemical Society Transactions 43 (4), 657-662, 2015 | 60 | 2015 |
| Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity A Ghallab, R Hassan, U Hofmann, A Friebel, Z Hobloss, L Brackhagen, ... Journal of Hepatology 77 (1), 71-83, 2022 | 54 | 2022 |
| Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney LM Shelton, A Lister, J Walsh, RE Jenkins, MHL Wong, C Rowe, E Ricci, ... Kidney international 88 (6), 1261-1273, 2015 | 54 | 2015 |
| Design and synthesis of irreversible analogues of bardoxolone methyl for the identification of pharmacologically relevant targets and interaction sites MHL Wong, HK Bryan, IM Copple, RE Jenkins, PH Chiu, J Bibby, ... Journal of Medicinal Chemistry 59 (6), 2396-2409, 2016 | 50 | 2016 |
| The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer JP Evans, BK Winiarski, PA Sutton, RP Jones, L Ressel, CA Duckworth, ... Oncotarget 9 (43), 27104, 2018 | 49 | 2018 |
| NRF2 as an emerging therapeutic target IM Copple, AT Dinkova-Kostova, TW Kensler, KT Liby, WC Wigley Oxidative medicine and cellular longevity 2017, 2017 | 47 | 2017 |
