Follow
Ganesha Rai
Ganesha Rai
NCATS
Verified email at mail.nih.gov
Title
Cited by
Cited by
Year
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate
ME Pacold, KR Brimacombe, SH Chan, JM Rohde, CA Lewis, ...
Nature chemical biology 12 (6), 452-458, 2016
4712016
High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells
LA Mathews Griner, R Guha, P Shinn, RM Young, JM Keller, D Liu, ...
Proceedings of the National Academy of Sciences 111 (6), 2349-2354, 2014
4052014
Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors
ONF King, XS Li, M Sakurai, A Kawamura, NR Rose, SS Ng, AM Quinn, ...
PloS one 5 (11), e15535, 2010
2442010
Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition
MV Gormally, TS Dexheimer, G Marsico, DA Sanders, C Lowe, ...
Nature communications 5 (1), 5165, 2014
2022014
Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124
DS Auld, S Lovell, N Thorne, WA Lea, DJ Maloney, M Shen, G Rai, ...
Proceedings of the National Academy of Sciences 107 (11), 4878-4883, 2010
1942010
KDM5 histone demethylase activity links cellular transcriptomic heterogeneity to therapeutic resistance
K Hinohara, HJ Wu, S Vigneau, TO McDonald, KJ Igarashi, KN Yamamoto, ...
Cancer cell 34 (6), 939-953. e9, 2018
1852018
Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction
JR Weaver, TR Holman, Y Imai, A Jadhav, V Kenyon, DJ Maloney, ...
Molecular and cellular endocrinology 358 (1), 88-95, 2012
1372012
Synthesis, biological evaluation, and structure–activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors
G Rai, VN Vyjayanti, D Dorjsuren, A Simeonov, A Jadhav, DM Wilson III, ...
Journal of medicinal chemistry 55 (7), 3101-3112, 2012
1252012
Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency
Y Liang, JL Vogel, JH Arbuckle, G Rai, A Jadhav, A Simeonov, ...
Science translational medicine 5 (167), 167ra5-167ra5, 2013
1192013
KDM5 histone demethylases repress immune response via suppression of STING
L Wu, J Cao, WL Cai, SM Lang, JR Horton, DJ Jansen, ZZ Liu, JF Chen, ...
PLoS biology 16 (8), e2006134, 2018
1132018
A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution
DS Auld, YQ Zhang, NT Southall, G Rai, M Landsman, J MacLure, ...
Journal of medicinal chemistry 52 (5), 1450-1458, 2009
1092009
Discovery and optimization of potent, cell-active pyrazole-based inhibitors of lactate dehydrogenase (LDH)
G Rai, KR Brimacombe, BT Mott, DJ Urban, X Hu, SM Yang, TD Lee, ...
Journal of medicinal chemistry 60 (22), 9184-9204, 2017
1082017
Preparation of 18F-human serum albumin: a simple and efficient protein labeling method with 18F using a hydrazone-formation method
YS Chang, JM Jeong, YS Lee, HW Kim, GB Rai, SJ Lee, DS Lee, ...
Bioconjugate chemistry 16 (5), 1329-1333, 2005
1062005
Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies
G Rai, N Joshi, JE Jung, Y Liu, L Schultz, A Yasgar, S Perry, G Diaz, ...
Journal of medicinal chemistry 57 (10), 4035-4048, 2014
1012014
Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1
G Rai, V Kenyon, A Jadhav, L Schultz, M Armstrong, JB Jameson, ...
Journal of medicinal chemistry 53 (20), 7392-7404, 2010
1012010
Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis
G Rai, AA Sayed, WA Lea, HF Luecke, H Chakrapani, S Prast-Nielsen, ...
Journal of medicinal chemistry 52 (20), 6474-6483, 2009
982009
Targeting glycolysis through inhibition of lactate dehydrogenase impairs tumor growth in preclinical models of Ewing sarcoma
C Yeung, AE Gibson, SH Issaq, N Oshima, JT Baumgart, LD Edessa, ...
Cancer research 79 (19), 5060-5073, 2019
972019
Structural basis for KDM5A histone lysine demethylase inhibition by diverse compounds
JR Horton, X Liu, M Gale, L Wu, JR Shanks, X Zhang, PJ Webber, ...
Cell chemical biology 23 (7), 769-781, 2016
952016
Dynamic imaging of LDH inhibition in tumors reveals rapid in vivo metabolic rewiring and vulnerability to combination therapy
N Oshima, R Ishida, S Kishimoto, K Beebe, JR Brender, K Yamamoto, ...
Cell reports 30 (6), 1798-1810. e4, 2020
892020
A widely-applicable high-throughput cellular thermal shift assay (CETSA) using split Nano Luciferase
NJ Martinez, RR Asawa, MG Cyr, A Zakharov, DJ Urban, JS Roth, ...
Scientific reports 8 (1), 9472, 2018
892018
The system can't perform the operation now. Try again later.
Articles 1–20