Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation NP Blackledge, AM Farcas, T Kondo, HW King, JF McGouran, ... Cell 157 (6), 1445-1459, 2014 | 805 | 2014 |
KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands AM Farcas, NP Blackledge, I Sudbery, HK Long, JF McGouran, NR Rose, ... elife 1, e00205, 2012 | 513 | 2012 |
Targeting Polycomb systems to regulate gene expression: modifications to a complex story NP Blackledge, NR Rose, RJ Klose Nature Reviews Molecular Cell Biology 16 (11), 643, 2015 | 403 | 2015 |
Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment S Cooper, M Dienstbier, R Hassan, L Schermelleh, J Sharif, ... Cell reports 7 (5), 1456-1470, 2014 | 369 | 2014 |
CpG islands recruit a histone H3 lysine 36 demethylase NP Blackledge, JC Zhou, MY Tolstorukov, AM Farcas, PJ Park, RJ Klose Molecular cell 38 (2), 179-190, 2010 | 361 | 2010 |
ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection HK Long, NP Blackledge, RJ Klose Biochemical Society Transactions 41 (3), 727-740, 2013 | 295 | 2013 |
Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates HK Long, D Sims, A Heger, NP Blackledge, C Kutter, ML Wright, ... Elife 2, e00348, 2013 | 229 | 2013 |
CpG island chromatin: a platform for gene regulation NP Blackledge, R Klose Epigenetics 6 (2), 147-152, 2011 | 185 | 2011 |
RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes NR Rose, HW King, NP Blackledge, NA Fursova, KJI Ember, R Fischer, ... Elife 5, e18591, 2016 | 146 | 2016 |
Chromatin sampling—an emerging perspective on targeting polycomb repressor proteins RJ Klose, S Cooper, AM Farcas, NP Blackledge, N Brockdorff PLoS genetics 9 (8), e1003717, 2013 | 144 | 2013 |
Intronic enhancers coordinate epithelial-specific looping of the active CFTR locus CJ Ott, NP Blackledge, JL Kerschner, SH Leir, GE Crawford, CU Cotton, ... Proceedings of the National Academy of Sciences, pnas. 0900946106, 2009 | 134 | 2009 |
The SET1 complex selects actively transcribed target genes via multivalent interaction with CpG island chromatin DA Brown, V Di Cerbo, A Feldmann, J Ahn, S Ito, NP Blackledge, ... Cell reports 20 (10), 2313-2327, 2017 | 95 | 2017 |
MLL-AF4 spreading identifies binding sites that are distinct from super-enhancers and that govern sensitivity to DOT1L inhibition in leukemia J Kerry, L Godfrey, E Repapi, M Tapia, NP Blackledge, H Ma, E Ballabio, ... Cell reports 18 (2), 482-495, 2017 | 83 | 2017 |
A complex intronic enhancer regulates expression of the CFTR gene by direct interaction with the promoter CJ Ott, M Suszko, NP Blackledge, JE Wright, GE Crawford, A Harris Journal of cellular and molecular medicine 13 (4), 680-692, 2009 | 80 | 2009 |
An insulator element 3′ to the CFTR gene binds CTCF and reveals an active chromatin hub in primary cells NP Blackledge, CJ Ott, AE Gillen, A Harris Nucleic acids research 37 (4), 1086-1094, 2009 | 68 | 2009 |
Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes HW King, NA Fursova, NP Blackledge, RJ Klose Genome research 28 (10), 1494-1507, 2018 | 66 | 2018 |
Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes. HW King, NA Fursova, NP Blackledge, RJ Klose bioRxiv, 280305, 2018 | 66 | 2018 |
CpG island chromatin is shaped by recruitment of ZF-CxxC proteins NP Blackledge, JP Thomson, PJ Skene Cold Spring Harbor perspectives in biology 5 (11), a018648, 2013 | 55 | 2013 |
CTCF mediates insulator function at the CFTR locus NP Blackledge, EJ Carter, JR Evans, V Lawson, RK Rowntree, A Harris Biochemical Journal 408 (2), 267-275, 2007 | 55 | 2007 |
Recognition of CpG island chromatin by KDM2A requires direct and specific interaction with linker DNA JC Zhou, NP Blackledge, AM Farcas, RJ Klose Molecular and cellular biology 32 (2), 479-489, 2012 | 54 | 2012 |