Dr Helena M Cochemé
Dr Helena M Cochemé
MRC London Institute of Medical Sciences, Imperial College London
Verified email at lms.mrc.ac.uk - Homepage
TitleCited byYear
Complex I is the major site of mitochondrial superoxide production by paraquat
HM Cochemé, MP Murphy
Journal of biological chemistry 283 (4), 1786-1798, 2008
4062008
Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism
F Cabreiro, C Au, KY Leung, N Vergara-Irigaray, HM Cochemé, T Noori, ...
Cell 153 (1), 228-239, 2013
3942013
Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology
MF Ross, GF Kelso, FH Blaikie, AM James, HM Cocheme, A Filipovska, ...
Biochemistry (Moscow) 70 (2), 222-230, 2005
3412005
Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I
ET Chouchani, C Methner, SM Nadtochiy, A Logan, VR Pell, S Ding, ...
Nature medicine 19 (6), 753, 2013
3322013
Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species: implications for the use of exogenous …
AM James, HM Cochemé, RAJ Smith, MP Murphy
Journal of Biological Chemistry, 2005
3222005
Superoxide Activates Uncoupling Proteins by Generating Carbon-centered Radicals and Initiating Lipid Peroxidation Studies Using A Mitochondria-Targeted Spin Trap Derived From Α …
MP Murphy, KS Echtay, FH Blaikie, J Asin-Cayuela, HM Cochemé, ...
Journal of Biological Chemistry 278 (49), 48534-48545, 2003
3042003
Mitochondrial pharmacology
RAJ Smith, RC Hartley, HM Cochemé, MP Murphy
Trends in pharmacological sciences 33 (6), 341-352, 2012
2912012
Mitochondria-targeted antioxidant MitoQ10 improves endothelial function and attenuates cardiac hypertrophy
D Graham, NN Huynh, CA Hamilton, E Beattie, RAJ Smith, HM Cochemé, ...
Hypertension 54 (2), 322-328, 2009
2582009
Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix
HM Cochemé, C Quin, SJ McQuaker, F Cabreiro, A Logan, TA Prime, ...
Cell metabolism 13 (3), 340-350, 2011
1992011
Mitochondrial redox signalling at a glance
Y Collins, ET Chouchani, AM James, KE Menger, HM Cochemé, ...
J Cell Sci 125 (4), 801-806, 2012
1732012
Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice
S Rodriguez-Cuenca, HM Cochemé, A Logan, I Abakumova, TA Prime, ...
Free Radical Biology and Medicine 48 (1), 161-172, 2010
1492010
Mitochondrial targeting of quinones: therapeutic implications
HM Cochemé, GF Kelso, AM James, MF Ross, J Trnka, T Mahendiran, ...
Mitochondrion 7, S94-S102, 2007
1082007
Mitochondria‐targeted antioxidants in the treatment of disease
RAJ Smith, VJ Adlam, FH Blaikie, ARB Manas, CM Porteous, AM James, ...
Annals of the New York Academy of Sciences 1147 (1), 105-111, 2008
972008
Genome‐wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling
N Alic, TD Andrews, ME Giannakou, I Papatheodorou, C Slack, ...
Molecular systems biology 7 (1), 502, 2011
832011
Oxidative stress and life histories: unresolved issues and current needs
JR Speakman, JD Blount, AM Bronikowski, R Buffenstein, C Isaksson, ...
Ecology and Evolution 5 (24), 5745-5757, 2015
812015
Mitochondria-targeted redox probes as tools in the study of oxidative damage and ageing
AM James, HM Cochemé, MP Murphy
Mechanisms of Ageing and Development 126 (9), 982-986, 2005
812005
Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila
HM Cochemé, A Logan, TA Prime, I Abakumova, C Quin, SJ McQuaker, ...
Nature protocols 7 (5), 946, 2012
782012
Using mitochondria-targeted molecules to study mitochondrial radical production and its consequences
RAJ Smith, GF Kelso, FH Blaikie, CM Porteous, EC Ledgerwood, ...
Biochemical Society Transactions 31 (6), 1295-1299, 2003
622003
Can antioxidants be effective therapeutics
HM Cocheme, MP Murphy
Curr Opin Investig Drugs 11 (4), 426-431, 2010
562010
Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction
KJ Kinghorn, JI Castillo-Quan, F Bartolome, PR Angelova, L Li, S Pope, ...
Brain 138 (7), 1801-1816, 2015
522015
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