Presbyopia and heat: changes associated with aging of the human lens suggest a functional role for the small heat shock protein, α‐crystallin, in maintaining lens flexibility KR Heys, MG Friedrich, RJW Truscott Aging cell 6 (6), 807-815, 2007 | 134 | 2007 |
The etiology of human age-related cataract. Proteins don't last forever RJW Truscott, MG Friedrich Biochimica et Biophysica Acta (BBA)-General Subjects 1860 (1), 192-198, 2016 | 129 | 2016 |
Old proteins in man: a field in its infancy RJW Truscott, KL Schey, MG Friedrich Trends in biochemical sciences 41 (8), 654-664, 2016 | 97 | 2016 |
Sphingolipid distribution changes with age in the human lens [S] JM Deeley, JA Hankin, MG Friedrich, RC Murphy, RJW Truscott, ... Journal of lipid research 51 (9), 2753-2760, 2010 | 85 | 2010 |
Free and bound water in normal and cataractous human lenses KR Heys, MG Friedrich, RJW Truscott Investigative ophthalmology & visual science 49 (5), 1991-1997, 2008 | 73 | 2008 |
Human prefrontal cortex phospholipids containing docosahexaenoic acid increase during normal adult aging, whereas those containing arachidonic acid decrease SE Norris, MG Friedrich, TW Mitchell, RJW Truscott, PL Else Neurobiology of aging 36 (4), 1659-1669, 2015 | 58 | 2015 |
Membrane association of proteins in the aging human lens: profound changes take place in the fifth decade of life MG Friedrich, RJW Truscott Investigative ophthalmology & visual science 50 (10), 4786-4793, 2009 | 57 | 2009 |
Molecular processes implicated in human age-related nuclear cataract RJW Truscott, MG Friedrich Investigative ophthalmology & visual science 60 (15), 5007-5021, 2019 | 54 | 2019 |
Isoaspartic acid is present at specific sites in myelin basic protein from multiple sclerosis patients: could this represent a trigger for disease onset? Michael G. Friedrich, Sarah E. Hancock, Mark J. Raftery, Roger J. W. Truscott Acta Neuropathologica Communications 4 (83), 2016 | 40 | 2016 |
Spatiotemporal changes in the human lens proteome: Critical insights into long-lived proteins KL Schey, Z Wang, MG Friedrich, DL Garland, RJW Truscott Progress in retinal and eye research 76, 100802, 2020 | 37 | 2020 |
Amyloid plaque in the human brain can decompose from Aβ1-40/1-42 by spontaneous non-enzymatic processes. B Lyons, MG Friedrich, MJ Raftery, RJW Truscott Analytical chemistry 88 (1), 2675-2684, 2016 | 37 | 2016 |
Decreases in phospholipids containing adrenic and arachidonic acids occur in the human hippocampus over the adult lifespan SE Hancock, MG Friedrich, TW Mitchell, RJW Truscott, PL Else Lipids 50 (9), 861-872, 2015 | 35 | 2015 |
Large-scale binding of α-crystallin to cell membranes of aged normal human lenses: a phenomenon that can be induced by mild thermal stress MG Friedrich, RJW Truscott Investigative Ophthalmology & Visual Science 51 (10), 5145-5152, 2010 | 35 | 2010 |
Is protein methylation in the human lens a result of non-enzymatic methylation by S-adenosylmethionine? RJW Truscott, J Mizdrak, MG Friedrich, MY Hooi, B Lyons, JF Jamie, ... Experimental eye research 99, 48-54, 2012 | 34 | 2012 |
The phospholipid composition of the human entorhinal cortex remains relatively stable over 80 years of adult aging SE Hancock, MG Friedrich, TW Mitchell, RJW Truscott, PL Else Geroscience 39 (1), 73-82, 2017 | 31 | 2017 |
Molecular signatures of long‐lived proteins: autolytic cleavage adjacent to serine residues SP Su, B Lyons, M Friedrich, JD McArthur, X Song, D Xavier, ... Aging cell 11 (6), 1125-1127, 2012 | 30 | 2012 |
Cleavage C-terminal to Asp leads to covalent crosslinking of long-lived human proteins Z Wang, MG Friedrich, RJW Truscott, KL Schey Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1867 (9), 831-839, 2019 | 28 | 2019 |
Tight binding of proteins to membranes from older human cells RJW Truscott, S Comte-Walters, Z Ablonczy, JH Schwacke, Y Berry, ... Age 33, 543-554, 2011 | 26 | 2011 |
Degradation of an old human protein: age-dependent cleavage of γS-crystallin generates a peptide that binds to cell membranes MG Friedrich, J Lam, RJW Truscott Journal of Biological Chemistry 287 (46), 39012-39020, 2012 | 25 | 2012 |
Mechanism of protein cleavage at asparagine leading to protein–protein cross-links MG Friedrich, Z Wang, KL Schey, RJW Truscott Biochemical Journal 476 (24), 3817-3834, 2019 | 23 | 2019 |