| Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming G Kochan, T Krojer, D Harvey, R Fischer, L Chen, M Vollmar, F von Delft, ... Proceedings of the National Academy of Sciences 108 (19), 7745-7750, 2011 | 278 | 2011 |
| A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis T Schwerd, SRF Twigg, D Aschenbrenner, S Manrique, KA Miller, ... Journal of Experimental Medicine 214 (9), 2547-2562, 2017 | 183 | 2017 |
| A genetics-led approach defines the drug target landscape of 30 immune-related traits H Fang, H De Wolf, B Knezevic, KL Burnham, J Osgood, A Sanniti, ... Nature genetics 51 (7), 1082-1091, 2019 | 167 | 2019 |
| Interaction of HLA‐B27 homodimers with KIR3DL1 and KIR3DL2, unlike HLA‐B27 heterotrimers, is independent of the sequence of bound peptide S Kollnberger, A Chan, MY Sun, L Ye Chen, C Wright, K di Gleria, ... European journal of immunology 37 (5), 1313-1322, 2007 | 137 | 2007 |
| Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis MH Al-Mossawi, L Chen, H Fang, A Ridley, J De Wit, N Yager, ... Nature communications 8 (1), 1510, 2017 | 129 | 2017 |
| Is Behçet's disease a ‘class 1-opathy’? The role of HLA-B* 51 in the pathogenesis of Behçet's disease M Giza, D Koftori, L Chen, P Bowness Clinical & Experimental Immunology 191 (1), 11-18, 2018 | 89 | 2018 |
| Critical role of endoplasmic reticulum aminopeptidase 1 in determining the length and sequence of peptides bound and presented by HLA–B27 L Chen, R Fischer, Y Peng, E Reeves, K McHugh, N Ternette, T Hanke, ... Arthritis & rheumatology 66 (2), 284-294, 2014 | 87 | 2014 |
| Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis L Chen, A Ridley, A Hammitzsch, MH Al-Mossawi, H Bunting, ... Annals of the rheumatic diseases 75 (5), 916-923, 2016 | 83 | 2016 |
| miR-10b-5p is a novel Th17 regulator present in Th17 cells from ankylosing spondylitis L Chen, MH Al-Mossawi, A Ridley, T Sekine, A Hammitzsch, J De Wit, ... Annals of the rheumatic diseases 76 (3), 620-625, 2017 | 69 | 2017 |
| An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation AR Roberts, M Vecellio, L Chen, A Ridley, A Cortes, JC Knight, ... Annals of the rheumatic diseases 75 (12), 2150-2156, 2016 | 54 | 2016 |
| ERAP1 and ankylosing spondylitis S Keidel, L Chen, J Pointon, P Wordsworth Current opinion in immunology 25 (1), 97-102, 2013 | 47 | 2013 |
| Genetic architecture of adaptive immune system identifies key immune regulators V Lagou, JE Garcia-Perez, I Smets, L Van Horebeek, M Vandebergh, ... Cell reports 25 (3), 798-810. e6, 2018 | 46 | 2018 |
| Roles of tetrahydrobiopterin in promoting tumor angiogenesis L Chen, X Zeng, J Wang, SS Briggs, E O'Neill, J Li, R Leek, DJ Kerr, ... The American journal of pathology 177 (5), 2671-2680, 2010 | 38 | 2010 |
| Inhibiting ex-vivo Th17 responses in Ankylosing Spondylitis by targeting Janus kinases A Hammitzsch, L Chen, J de Wit, MH Al-Mossawi, A Ridley, T Sekine, ... Scientific Reports 8 (1), 15645, 2018 | 33 | 2018 |
| Deficiency of filaggrin regulates endogenous cysteine protease activity, leading to impaired skin barrier function XW Wang, JJ Wang, D Gutowska‐Owsiak, M Salimi, TA Selvakumar, ... Clinical and Experimental Dermatology 42 (6), 622-631, 2017 | 31 | 2017 |
| From genome-wide association studies to rational drug target prioritisation in inflammatory arthritis H Fang, L Chen, JC Knight The Lancet Rheumatology 2 (1), e50-e62, 2020 | 24 | 2020 |
| GM-CSF primes proinflammatory monocyte responses in ankylosing spondylitis H Shi, L Chen, A Ridley, N Zaarour, I Brough, C Caucci, JE Smith, ... Frontiers in Immunology 11, 1520, 2020 | 20 | 2020 |
| Identification of an unconventional subpeptidome bound to the Behçet's disease-associated HLA-B* 51: 01 that is regulated by endoplasmic reticulum aminopeptidase 1 (ERAP1) L Chen, H Shi, D Koftori, T Sekine, A Nicastri, N Ternette, P Bowness Molecular & Cellular Proteomics 19 (5), 871-883, 2020 | 20 | 2020 |
| From the genetics of ankylosing spondylitis to new biology and drug target discovery Z Nancy, L Yan, S Hui, B Paul, C Liye Frontiers in Immunology 12, 624632, 2021 | 19 | 2021 |
| Position 97 of HLA-B, a residue implicated in pathogenesis of ankylosing spondylitis, plays a key role in cell surface free heavy chain expression L Chen, H Shi, J Yuan, P Bowness Annals of the Rheumatic Diseases 76 (3), 593-601, 2017 | 19 | 2017 |
Julian KnightProfessor of Genomic Medicine, University of OxfordVerified email at well.ox.ac.uk
