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Hye Jin Kang
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Virtual discovery of melatonin receptor ligands to modulate circadian rhythms
RM Stein, HJ Kang, JD McCorvy, GC Glatfelter, AJ Jones, T Che, ...
Nature 579 (7800), 609-614, 2020
2272020
Effects of ketamine and ketamine metabolites on evoked striatal dopamine release, dopamine receptors, and monoamine transporters
A Can, P Zanos, R Moaddel, HJ Kang, KSS Dossou, IW Wainer, JF Cheer, ...
Journal of Pharmacology and Experimental Therapeutics 359 (1), 159-170, 2016
1192016
Structure, function and pharmacology of human itch GPCRs
C Cao, HJ Kang, I Singh, H Chen, C Zhang, W Ye, BW Hayes, J Liu, ...
Nature 600 (7887), 170-175, 2021
1132021
Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation
MN McCarroll, L Gendelev, R Kinser, J Taylor, G Bruni, D Myers-Turnbull, ...
Nature communications 10 (1), 4078, 2019
332019
Protamine is an antagonist of apelin receptor, and its activity is reversed by heparin
S Le Gonidec, C Chaves-Almagro, Y Bai, HJ Kang, A Smith, E Wanecq, ...
The FASEB Journal 31 (6), 2507, 2017
322017
Synthesis and Preliminary Studies of a Novel Negative Allosteric Modulator, 7-((2,5-Dioxopyrrolidin-1-yl)methyl)-4-(2-fluoro-4-[11C]methoxyphenyl) quinoline-2 …
X Zhang, K Kumata, T Yamasaki, R Cheng, A Hatori, L Ma, Y Zhang, L Xie, ...
ACS Chemical Neuroscience 8 (9), 1937-1948, 2017
262017
Target deconvolution studies of (2R, 6R)-hydroxynorketamine: an elusive search
J Bonaventura, JL Gomez, ML Carlton, S Lam, M Sanchez-Soto, PJ Morris, ...
Molecular psychiatry 27 (10), 4144-4156, 2022
212022
Neurotensin receptor allosterism revealed in complex with a biased allosteric modulator
BE Krumm, JF DiBerto, RHJ Olsen, HJ Kang, ST Slocum, S Zhang, ...
Biochemistry 62 (7), 1233-1248, 2023
192023
A promising chemical series of positive allosteric modulators of the μ-opioid receptor that enhance the antinociceptive efficacy of opioids but not their adverse effects
KD Pryce, HJ Kang, F Sakloth, Y Liu, S Khan, K Toth, A Kapoor, A Nicolais, ...
Neuropharmacology 195, 108673, 2021
182021
Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands
E Ofori, XY Zhu, JR Etukala, K Peprah, KR Jordan, AA Adkins, BA Bricker, ...
Bioorganic & medicinal chemistry 24 (16), 3464-3471, 2016
182016
Determinants of endogenous ligand specificity divergence among metabotropic glutamate receptors
HJ Kang, AD Wilkins, O Lichtarge, TG Wensel
Journal of Biological Chemistry 290 (5), 2870-2878, 2015
172015
Selectivity and evolutionary divergence of metabotropic glutamate receptors for endogenous ligands and G proteins coupled to phospholipase C or TRP channels
HJ Kang, K Menlove, J Ma, A Wilkins, O Lichtarge, TG Wensel
Journal of Biological Chemistry 289 (43), 29961-29974, 2014
172014
Synthesis and Characterization of [18F]JNJ-46356479 as the First 18F-Labeled PET Imaging Ligand for Metabotropic Glutamate Receptor 2
G Yuan, NJ Guehl, B Zheng, X Qu, SH Moon, M Dhaynaut, TM Shoup, ...
Molecular imaging and biology 23, 527-536, 2021
92021
Re-exploring the N-phenylpicolinamide derivatives to develop mGlu4 ligands with improved affinity and in vitro microsomal stability
Z Zhang, KE Kil, P Poutiainen, JK Choi, HJ Kang, XP Huang, BL Roth, ...
Bioorganic & medicinal chemistry letters 25 (18), 3956-3960, 2015
92015
Structural insights into the human niacin receptor HCA2-Gi signalling complex
Y Yang, HJ Kang, R Gao, J Wang, GW Han, JF DiBerto, L Wu, J Tong, ...
Nature communications 14 (1), 1692, 2023
72023
Design, synthesis, and characterization of benzimidazole derivatives as positron emission tomography imaging ligands for metabotropic glutamate receptor 2
G Yuan, X Qu, B Zheng, R Neelamegam, S Afshar, S Iyengar, C Pan, ...
Journal of Medicinal Chemistry 63 (20), 12060-12072, 2020
62020
Synthesis and Characterization of Fluorine-18-Labeled N-(4-Chloro-3-((fluoromethyl-d2)thio)phenyl)picolinamide for Imaging of mGluR4 in Brain
J Wang, X Qu, TM Shoup, G Yuan, S Afshar, C Pan, A Zhu, JK Choi, ...
Journal of medicinal chemistry 63 (6), 3381-3389, 2020
62020
Evaluation of SYA16263 as a new potential antipsychotic agent without catalepsy
BA Bricker, K Peprah, HJ Kang, SY Ablordeppey
Pharmacology Biochemistry and Behavior 179, 55-62, 2019
62019
Design, Synthesis, and Characterization of [18F]mG2P026 as a High-Contrast PET Imaging Ligand for Metabotropic Glutamate Receptor 2
G Yuan, M Dhaynaut, NJ Guehl, S Afshar, D Huynh, SH Moon, ...
Journal of medicinal chemistry 65 (14), 9939-9954, 2022
52022
Development of CNS multi-receptor ligands: modification of known D2 pharmacophores
JR Etukala, XY Zhu, SVK Eyunni, EK Onyameh, E Ofori, BA Bricker, ...
Bioorganic & medicinal chemistry 24 (16), 3671-3679, 2016
52016
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