Marco Falasca
Marco Falasca
Professor of Metabolism, Curtin University
Verified email at
TitleCited byYear
Activation of phospholipase Cγ by PI 3‐kinase‐induced PH domain‐mediated membrane targeting
M Falasca, SK Logan, VP Lehto, G Baccante, MA Lemmon, ...
The EMBO journal 17 (2), 414-422, 1998
Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains
JM Kavran, DE Klein, A Lee, M Falasca, SJ Isakoff, EY Skolnik, ...
Journal of Biological Chemistry 273 (46), 30497-30508, 1998
A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling
GA Rodrigues, M Falasca, Z Zhang, SH Ong, J Schlessinger
Molecular and cellular biology 20 (4), 1448-1459, 2000
Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration
M Okigaki, C Davis, M Falasca, S Harroch, DP Felsenfeld, MP Sheetz, ...
Proceedings of the National Academy of Sciences 100 (19), 10740-10745, 2003
Insulin induces phosphatidylinositol‐3‐phosphate formation through TC10 activation
T Maffucci, A Brancaccio, E Piccolo, RC Stein, M Falasca
The EMBO journal 22 (16), 4178-4189, 2003
Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration
T Maffucci, FT Cooke, FM Foster, CJ Traer, MJ Fry, M Falasca
The Journal of cell biology 169 (5), 789-799, 2005
The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation
R Pineiro, T Maffucci, M Falasca
Oncogene 30 (2), 142, 2011
Regulatory recruitment of signalling molecules to the cell membrane by pleckstrinhomology domains
MA Lemmon, M Falasca, J Schlessinger, K Ferguson
Trends in cell biology 7 (6), 237-242, 1997
The role of phosphoinositide 3-kinase C2α in insulin signaling
M Falasca, WE Hughes, V Dominguez, G Sala, F Fostira, MQ Fang, ...
Journal of Biological Chemistry 282 (38), 28226-28236, 2007
Inhibition of the phosphatidylinositol 3-kinase/Akt pathway by inositol pentakisphosphate results in antiangiogenic and antitumor effects
T Maffucci, E Piccolo, A Cumashi, M Iezzi, AM Riley, A Saiardi, ...
Cancer Research 65 (18), 8339-8349, 2005
Phosphatidylinositol 3-kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway.
SK Logan, M Falasca, P Hu, J Schlessinger
Molecular and cellular biology 17 (10), 5784-5790, 1997
Specificity in pleckstrin homology (PH) domain membrane targeting: a role for a phosphoinositide–protein co‐operative mechanism
T Maffucci, M Falasca
FEBS letters 506 (3), 173-179, 2001
Phospholipase Cγ1 is required for metastasis development and progression
G Sala, F Dituri, C Raimondi, S Previdi, T Maffucci, M Mazzoletti, C Rossi, ...
Cancer research 68 (24), 10187-10196, 2008
Role of class II phosphoinositide 3-kinase in cell signalling
M Falasca, T Maffucci
Biochemical Society Transactions 35 (2), 211-214, 2007
Regulation and cellular functions of class II phosphoinositide 3-kinases
M Falasca, T Maffucci
Biochemical Journal 443 (3), 587-601, 2012
The mechanism involved in the regulation of phospholipase Cγ1 activity in cell migration
E Piccolo, PF Innominato, MA Mariggio, T Maffucci, S Iacobelli, M Falasca
Oncogene 21 (42), 6520, 2002
PI3K/Akt signalling pathway specific inhibitors: a novel strategy to sensitize cancer cells to anti-cancer drugs
M Falasca
Current pharmaceutical design 16 (12), 1410-1416, 2010
PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function
I Franco, F Gulluni, CC Campa, C Costa, JP Margaria, E Ciraolo, ...
Developmental cell 28 (6), 647-658, 2014
Investigational ABC transporter inhibitors
M Falasca, KJ Linton
Expert opinion on investigational drugs 21 (5), 657-666, 2012
Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway
E Piccolo, S Vignati, T Maffucci, PF Innominato, AM Riley, BVL Potter, ...
Oncogene 23 (9), 1754, 2004
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