Elton Zeqiraj
Elton Zeqiraj
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Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation
E Zeqiraj, BM Filippi, M Deak, DR Alessi, DMF Van Aalten
Science 326 (5960), 1707-1711, 2009
A strategy for modulation of enzymes in the ubiquitin system
A Ernst, G Avvakumov, J Tong, Y Fan, Y Zhao, P Alberts, A Persaud, ...
Science 339 (6119), 590-595, 2013
Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase
RW Hunter, CC Hughey, L Lantier, EI Sundelin, M Peggie, E Zeqiraj, ...
Nature medicine 24 (9), 1395-1406, 2018
Pseudokinases-remnants of evolution or key allosteric regulators?
E Zeqiraj, DMF van Aalten
Current opinion in structural biology 20 (6), 772-781, 2010
ATP and MO25α regulate the conformational state of the STRADα pseudokinase and activation of the LKB1 tumour suppressor
E Zeqiraj, BM Filippi, S Goldie, I Navratilova, J Boudeau, M Deak, ...
PLoS biology 7 (6), e1000126, 2009
MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases
BM Filippi, P De Los Heros, Y Mehellou, I Navratilova, R Gourlay, M Deak, ...
The EMBO journal 30 (9), 1730-1741, 2011
Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity
H Huang, E Zeqiraj, B Dong, BK Jha, NM Duffy, S Orlicky, ...
Molecular cell 53 (2), 221-234, 2014
Structure of an SspH1-PKN1 complex reveals the basis for host substrate recognition and mechanism of activation for a bacterial E3 ubiquitin ligase
AFA Keszei, X Tang, C McCormick, E Zeqiraj, JR Rohde, M Tyers, ...
Molecular and cellular biology 34 (3), 362-373, 2014
Emerging concepts in pseudoenzyme classification, evolution, and signaling
AJM Ribeiro, S Das, N Dawson, R Zaru, S Orchard, JM Thornton, ...
Science Signaling 12 (594), eaat9797, 2019
Structural basis for specificity of TGFβ family receptor small molecule inhibitors
AA Ogunjimi, E Zeqiraj, DF Ceccarelli, F Sicheri, JL Wrana, L David
Cellular signalling 24 (2), 476-483, 2012
Metabolic control of BRISC–SHMT2 assembly regulates immune signalling
M Walden, L Tian, RL Ross, UM Sykora, DP Byrne, EL Hesketh, ...
Nature 570 (7760), 194-199, 2019
Structural basis for the recruitment of glycogen synthase by glycogenin
E Zeqiraj, X Tang, RW Hunter, M García-Rocha, A Judd, M Deak, ...
Proceedings of the National Academy of Sciences 111 (28), E2831-E2840, 2014
Higher-order assembly of BRCC36–KIAA0157 is required for DUB activity and biological function
E Zeqiraj, L Tian, CA Piggott, MC Pillon, NM Duffy, DF Ceccarelli, ...
Molecular cell 59 (6), 970-983, 2015
Proteome analysis of metastatic colorectal cancer cells recognized by the lectin Helix pomatia agglutinin (HPA)
J Saint‐Guirons, E Zeqiraj, U Schumacher, P Greenwell, M Dwek
Proteomics 7 (22), 4082-4089, 2007
Getting a handle on glycogen synthase–Its interaction with glycogenin
E Zeqiraj, F Sicheri
Molecular aspects of medicine 46, 63-69, 2015
Pseudo-DUBs as allosteric activators and molecular scaffolds of protein complexes
M Walden, SK Masandi, K Pawłowski, E Zeqiraj
Biochemical Society Transactions 46 (2), 453-466, 2018
Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase
SN Shehata, RW Hunter, E Ohta, MW Peggie, HJ Lou, F Sicheri, E Zeqiraj, ...
Cellular signalling 24 (11), 2085-2094, 2012
Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965
D Ahwazi, K Neopane, GR Markby, F Kopietz, AJ Ovens, M Dall, ...
Biochemical Journal 478 (15), 2977-2997, 2021
Expression and purification of functional human glycogen synthase-1: glycogenin-1 complex in insect cells
RW Hunter, E Zeqiraj, N Morrice, F Sicheri, K Sakamoto
Protein expression and purification 108, 23-29, 2015
Mechanism of glycogen synthase inactivation and interaction with glycogenin
L Marr, D Biswas, LA Daly, C Browning, SCM Vial, DP Maskell, C Hudson, ...
Nature Communications 13 (1), 3372, 2022
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