| Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection V Summa, A Petrocchi, F Bonelli, B Crescenzi, M Donghi, M Ferrara, ... Journal of medicinal chemistry 51 (18), 5843-5855, 2008 | 729 | 2008 |
| Discovery of 2-{4-[(3S)-Piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): A Novel Oral Poly(ADP-ribose)polymerase (PARP) Inhibitor Efficacious in … P Jones, S Altamura, J Boueres, F Ferrigno, M Fonsi, C Giomini, ... Journal of medicinal chemistry 52 (22), 7170-7185, 2009 | 341 | 2009 |
| MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants V Summa, SW Ludmerer, JA McCauley, C Fandozzi, C Burlein, G Claudio, ... Antimicrobial agents and chemotherapy 56 (8), 4161-4167, 2012 | 297 | 2012 |
| Mechanismof Action and Antiviral Activity of Benzimidazole-Based AllostericInhibitors of the Hepatitis C Virus RNA-Dependent RNAPolymerase L Tomei, S Altamura, L Bartholomew, A Biroccio, A Ceccacci, L Pacini, ... Journal of virology 77 (24), 13225-13231, 2003 | 240 | 2003 |
| Fluorination of 3-(3-(piperidin-1-yl) propyl) indoles and 3-(3-(piperazin-1-yl) propyl) indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles MB van Niel, I Collins, MS Beer, HB Broughton, SKF Cheng, ... Journal of medicinal chemistry 42 (12), 2087-2104, 1999 | 227 | 1999 |
| Current and novel approaches to the drug treatment of schizophrenia M Rowley, LJ Bristow, PH Hutson Journal of medicinal chemistry 44 (4), 477-501, 2001 | 210 | 2001 |
| Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site S Di Marco, C Volpari, L Tomei, S Altamura, S Harper, F Narjes, U Koch, ... Journal of Biological Chemistry 280 (33), 29765-29770, 2005 | 205 | 2005 |
| Discovery of MK-5172, a macrocyclic hepatitis C virus NS3/4a protease inhibitor S Harper, JA McCauley, MT Rudd, M Ferrara, M DiFilippo, B Crescenzi, ... ACS medicinal chemistry letters 3 (4), 332-336, 2012 | 199 | 2012 |
| 3'-(Arylmethyl)-and 3'-(aryloxy)-3-phenyl-4-hydroxyquinolin-2 (1H)-ones: orally active antagonists of the glycine site on the NMDA receptor JJ Kulagowski, R Baker, NR Curtis, IM Mawer, AM Moseley, MP Ridgill, ... Journal of medicinal chemistry 37 (10), 1402-1405, 1994 | 170 | 1994 |
| Effect of plasma protein binding on in vivo activity and brain penetration of glycine/NMDA receptor antagonists M Rowley, JJ Kulagowski, AP Watt, D Rathbone, GI Stevenson, ... Journal of medicinal chemistry 40 (25), 4053-4068, 1997 | 169 | 1997 |
| 3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT2A receptor antagonists M Rowley, DJ Hallett, S Goodacre, C Moyes, J Crawforth, TJ Sparey, ... Journal of medicinal chemistry 44 (10), 1603-1614, 2001 | 160 | 2001 |
| 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl) piperidin-4-yl) isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors M Rowley, HB Broughton, I Collins, R Baker, F Emms, R Marwood, ... Journal of medicinal chemistry 39 (10), 1943-1945, 1996 | 157 | 1996 |
| 3-Heteroaryl-2-pyridones: Benzodiazepine site ligands with functional selectivity for α2/α3-subtypes of human GABAA receptor-ion channels I Collins, C Moyes, WB Davey, M Rowley, FA Bromidge, K Quirk, JR Atack, ... Journal of medicinal chemistry 45 (9), 1887-1900, 2002 | 156 | 2002 |
| Total synthesis of (+)-ophiobolin C M Rowley, M Tsukamoto, Y Kishi Journal of the American Chemical Society 111 (7), 2735-2737, 1989 | 154 | 1989 |
| Niraparib: a poly (ADP-ribose) polymerase (PARP) inhibitor for the treatment of tumors with defective homologous recombination P Jones, K Wilcoxen, M Rowley, C Toniatti Journal of medicinal chemistry 58 (8), 3302-3314, 2015 | 152 | 2015 |
| 4,5-Dihydroxypyrimidine Carboxamides and N-Alkyl-5-hydroxypyrimidinone Carboxamides Are Potent, Selective HIV Integrase Inhibitors with Good … V Summa, A Petrocchi, VG Matassa, C Gardelli, E Muraglia, M Rowley, ... Journal of medicinal chemistry 49 (23), 6646-6649, 2006 | 146 | 2006 |
| Potent inhibitors of subgenomic hepatitis C virus RNA replication through optimization of indole-N-acetamide allosteric inhibitors of the viral NS5B polymerase S Harper, S Avolio, B Pacini, M Di Filippo, S Altamura, L Tomei, ... Journal of medicinal chemistry 48 (14), 4547-4557, 2005 | 131 | 2005 |
| Dihydroxypyrimidine-4-carboxamides as novel potent and selective HIV integrase inhibitors P Pace, ME Di Francesco, C Gardelli, S Harper, E Muraglia, E Nizi, ... Journal of medicinal chemistry 50 (9), 2225-2239, 2007 | 123 | 2007 |
| 3-Acyl-4-hydroxyquinolin-2 (1H)-ones. Systemically active anticonvulsants acting by antagonism at the glycine site of the N-methyl-D-aspartate receptor complex M Rowley, PD Leeson, GI Stevenson, AM Moseley, I Stansfield, ... Journal of medicinal chemistry 36 (22), 3386-3396, 1993 | 120 | 1993 |
| Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases P Jones, S Altamura, R De Francesco, P Gallinari, A Lahm, ... Bioorganic & medicinal chemistry letters 18 (6), 1814-1819, 2008 | 119 | 2008 |
