Stuart J Conway
Stuart J Conway
Professor of Organic Chemistry, University of Oxford
Verified email at - Homepage
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Bcl-2 functionally interacts with inositol 1, 4, 5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1, 4, 5-trisphosphate
R Chen, I Valencia, F Zhong, KS McColl, HL Roderick, MD Bootman, ...
The Journal of cell biology 166 (2), 193-203, 2004
2-Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1, 4, 5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible …
CM Peppiatt, TJ Collins, L Mackenzie, SJ Conway, AB Holmes, ...
Cell Calcium 34 (1), 97-108, 2003
Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains
DA Hay, O Fedorov, S Martin, DC Singleton, C Tallant, C Wells, S Picaud, ...
Journal of the American Chemical Society 136 (26), 9308-9319, 2014
3, 5-Dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands
DS Hewings, M Wang, M Philpott, O Fedorov, S Uttarkar, ...
Journal of medicinal chemistry 54 (19), 6761-6770, 2011
Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins
AM Holmes, MD Bootman, K Rietdorf, F McDonald, SJ Conway, ...
The EMBO journal 23 (2), 312-21, 2004
Progress in the Development and Application of Small Molecule Inhibitors of Bromodomain–Acetyl-lysine Interactions
DS Hewings, TPC Rooney, LE Jennings, DA Hay, CJ Schofield, ...
Journal of Medicinal Chemistry 55 (22), 9393-9413, 2012
The spatial pattern of atrial cardiomyocyte calcium signalling modulates contraction
L Mackenzie, HL Roderick, MJ Berridge, SJ Conway, MD Bootman
Journal of cell science 117 (26), 6327-6337, 2004
The use of phosphate bioisosteres in medicinal chemistry and chemical biology
TS Elliott, A Slowey, Y Ye, SJ Conway
MedChemComm 3 (7), 735-751, 2012
Small molecule inhibitors of bromodomain–acetyl-lysine interactions
M Brand, AM Measures, BG Wilson, WA Cortopassi, R Alexander, ...
ACS chemical biology 10 (1), 22-39, 2015
Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy
D Harzheim, M Movassagh, RSY Foo, O Ritter, A Tashfeen, SJ Conway, ...
Proceedings of the National Academy of Sciences 106 (27), 11406-11411, 2009
Inositol 1, 4, 5-trisphosphate supports the arrhythmogenic action of endothelin-1 on ventricular cardiac myocytes
A Proven, HL Roderick, SJ Conway, MJ Berridge, JK Horton, SJ Capper, ...
Journal of cell science 119 (16), 3363-3375, 2006
Optimization of 3, 5-Dimethylisoxazole Derivatives as Potent Bromodomain Ligands
DS Hewings, O Fedorov, P Filippakopoulos, S Martin, S Picaud, A Tumber, ...
Journal of medicinal chemistry 56 (8), 3217-3227, 2013
The proapoptotic factors Bax and Bak regulate T cell proliferation through control of endoplasmic reticulum Ca 2+ homeostasis
RG Jones, T Bui, C White, M Madesh, CM Krawczyk, T Lindsten, ...
Immunity 27 (2), 268-280, 2007
NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing
LC Davis, AJ Morgan, JL Chen, CM Snead, D Bloor-Young, E Shenderov, ...
Current Biology 22 (24), 2331-2337, 2012
A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced‐Fit Pocket Stabilized by a Cation–π Interaction
TPC Rooney, P Filippakopoulos, O Fedorov, S Picaud, WA Cortopassi, ...
Angewandte Chemie International Edition 53 (24), 6126-6130, 2014
The consequences of mitochondrial amyloid β-peptide in Alzheimer's disease
KEA Muirhead, E Borger, L Aitken, SJ Conway, FJ Gunn-Moore
Biochemical Journal 426 (3), 255-270, 2010
Clinical advances of hypoxia-activated prodrugs in combination with radiation therapy
IN Mistry, M Thomas, EDD Calder, SJ Conway, EM Hammond
International Journal of Radiation Oncology• Biology• Physics 98 (5), 1183-1196, 2017
Distinct intracellular calcium transients in neurites and somata integrate neuronal signals
FW Johenning, M Zochowski, SJ Conway, AB Holmes, P Koulen, ...
Journal of Neuroscience 22 (13), 5344-5353, 2002
Biology-enabling inositol phosphates, phosphatidylinositol phosphates and derivatives
SJ Conway, GJ Miller
Natural product reports 24 (4), 687-707, 2007
TRPing the switch on pain: an introduction to the chemistry and biology of capsaicin and TRPV1
SJ Conway
Chemical Society Reviews 37 (8), 1530-1545, 2008
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