Douglas P Dyer
Douglas P Dyer
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TSG-6 inhibits neutrophil migration via direct interaction with the chemokine CXCL8
DP Dyer, JM Thomson, A Hermant, TA Jowitt, TM Handel, AEI Proudfoot, ...
The Journal of Immunology 192 (5), 2177-2185, 2014
The anti-inflammatory protein TSG-6 regulates chemokine function by inhibiting chemokine/glycosaminoglycan interactions
DP Dyer, CL Salanga, SC Johns, E Valdambrini, MM Fuster, CM Milner, ...
Journal of Biological Chemistry 291 (24), 12627-12640, 2016
The dependence of chemokine–glycosaminoglycan interactions on chemokine oligomerization
DP Dyer, CL Salanga, BF Volkman, T Kawamura, TM Handel
Glycobiology 26 (3), 312-326, 2016
Chemokine receptor redundancy and specificity are context dependent
DP Dyer, L Medina-Ruiz, R Bartolini, F Schuette, CE Hughes, K Pallas, ...
Immunity 50 (2), 378-389. e5, 2019
The extracellular matrix and the immune system: A mutually dependent relationship
TE Sutherland, DP Dyer, JE Allen
Science 379 (6633), eabp8964, 2023
Immunomodulation by radiotherapy in tumour control and normal tissue toxicity
UM Cytlak, DP Dyer, J Honeychurch, KJ Williams, MA Travis, TM Illidge
Nature Reviews Immunology 22 (2), 124-138, 2022
Cytokines and growth factors cross-link heparan sulfate
E Migliorini, D Thakar, J Kühnle, R Sadir, DP Dyer, Y Li, C Sun, ...
Open biology 5 (8), 150046, 2015
A refined model for the TSG-6 link module in complex with hyaluronan: use of defined oligosaccharides to probe structure and function
VA Higman, DC Briggs, DJ Mahoney, CD Blundell, BM Sattelle, DP Dyer, ...
Journal of Biological Chemistry 289 (9), 5619-5634, 2014
Understanding the mechanisms that facilitate specificity, not redundancy, of chemokine‐mediated leukocyte recruitment
DP Dyer
Immunology 160 (4), 336-344, 2020
Multiple glycosaminoglycan-binding epitopes of monocyte chemoattractant protein-3/CCL7 enable it to function as a non-oligomerizing chemokine
CL Salanga, DP Dyer, JG Kiselar, S Gupta, MR Chance, TM Handel
Journal of Biological Chemistry 289 (21), 14896-14912, 2014
Differential structural remodelling of heparan sulfate by chemokines: the role of chemokine oligomerization
DP Dyer, E Migliorini, CL Salanga, D Thakar, TM Handel, RP Richter
Open biology 7 (1), 160286, 2017
Kinetics of CXCL12 binding to atypical chemokine receptor 3 reveal a role for the receptor N terminus in chemokine binding
M Gustavsson, DP Dyer, C Zhao, TM Handel
Science signaling 12 (598), eaaw3657, 2019
Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates
R Karlsson, P Chopra, A Joshi, Z Yang, SY Vakhrushev, TM Clausen, ...
Science advances 7 (52), eabl6026, 2021
Identification of the pharmacophore of the CC chemokine-binding proteins Evasin-1 and-4 using phage display
P Bonvin, SM Dunn, F Rousseau, DP Dyer, J Shaw, CA Power, ...
Journal of Biological Chemistry 289 (46), 31846-31855, 2014
CXCR2 deficient mice display macrophage-dependent exaggerated acute inflammatory responses
DP Dyer, K Pallas, L Medina-Ruiz, F Schuette, GJ Wilson, GJ Graham
Scientific Reports 7 (1), 42681, 2017
Role of extracellular matrix proteoglycans in immune cell recruitment
AL Gray, N Pun, AJL Ridley, DP Dyer
International Journal of Experimental Pathology 103 (2), 34-43, 2022
Perspectives on the biological role of chemokine: glycosaminoglycan interactions
TM Handel, DP Dyer
Journal of Histochemistry & Cytochemistry 69 (2), 87-91, 2021
Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors
AL Gray, R Karlsson, ARE Roberts, AJL Ridley, N Pun, B Khan, ...
Cell Reports 42 (1), 2023
Examination of glycosaminoglycan binding sites on the XCL1 dimer
JC Fox, RC Tyler, FC Peterson, DP Dyer, F Zhang, RJ Linhardt, ...
Biochemistry 55 (8), 1214-1225, 2016
The chemokine receptor CXCR2 contributes to murine adipocyte development
DP Dyer, JB Nebot, CJ Kelly, L Medina-Ruiz, F Schuette, GJ Graham
Journal of leukocyte biology 105 (3), 497-506, 2019
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