| Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme T Lotta, J Vidgren, C Tilgmann, I Ulmanen, K Melen, I Julkunen, ... Biochemistry 34 (13), 4202-4210, 1995 | 1433 | 1995 |
| Binding of a new Ca2+ sensitizer, levosimendan, to recombinant human cardiac troponin C. A molecular modelling, fluorescence probe, and proton nuclear magnetic resonance study. P Pollesello, M Ovaska, J Kaivola, C Tilgmann, K Lundström, N Kalkkinen, ... Journal of Biological Chemistry 269 (46), 28584-28590, 1994 | 305 | 1994 |
| Characteristics of catechol O-methyl-transferase (COMT) and properties of selective COMT inhibitors PT Männistö, I Ulmanen, K Lundström, J Taskinen, J Tenhunen, ... Progress in drug research. Fortschritte der Arzneimittelforschung. Progres …, 1992 | 269* | 1992 |
| Genetic polymorphism of catechol-O-methyltransferase (COMT): correlation of genotype with individual variation of S-COMT activity and comparison of the allele frequencies in … AC Syvänen, C Tilgmann, J Rhine, I Ulmanen Pharmacogenetics and Genomics 7 (1), 65-71, 1997 | 203 | 1997 |
| Cloning, expression and structure of catechol-O-methyltransferase K Lundström, J Tenhunen, C Tilgmann, T Karhunen, P Panula, I Ulmanen Biochimica et Biophysica Acta (BBA)-Protein Structure and Molecular …, 1995 | 198 | 1995 |
| Binding of levosimendan, a calcium sensitizer, to cardiac troponin C T Sorsa, S Heikkinen, MB Abbott, E Abusamhadneh, T Laakso, ... Journal of biological chemistry 276 (12), 9337-9343, 2001 | 187 | 2001 |
| Molecular cloning and characterization of rat liver catechol-O-methyltransferase M Salminen, K Lundström, C Tilgmann, R Savolainen, N Kalkkinen, ... Gene 93 (2), 241-247, 1990 | 150 | 1990 |
| Distribution of catechol-O-methyltransferase enzyme in rat tissues. T Karhunen, C Tilgmann, I Ulmanen, I Julkunen, P Panula Journal of Histochemistry & Cytochemistry 42 (8), 1079-1090, 1994 | 147 | 1994 |
| Expression and Intracellular Localization of Catechol O‐methyltransferase in Transfected Mammalian Cells I Ulmanen, J Peränen, J Tenhunen, C Tilgmann, T Karhunen, P Panula, ... European Journal of Biochemistry 243 (1‐2), 452-459, 1997 | 140 | 1997 |
| Compensatory mechanisms associated with the hyperdynamic function of phospholamban-deficient mouse hearts G Chu, W Luo, JP Slack, C Tilgmann, WE Sweet, M Spindler, KW Saupe, ... Circulation research 79 (6), 1064-1076, 1996 | 137 | 1996 |
| Aspartic proteinase from barley grains is related to mammalian lysosomal cathepsin D P Sarkkinen, N Kalkkinen, C Tilgmann, J Siuro, J Kervinen, L Mikola Planta 186, 317-323, 1992 | 134 | 1992 |
| Further evidence for the cardiac troponin C mediated calcium sensitization by levosimendan: structure-response and binding analysis with analogs of levosimendan J Levijoki, P Pollesello, J Kaivola, C Tilgmann, T Sorsa, A Annila, ... Journal of molecular and cellular cardiology 32 (3), 479-491, 2000 | 104 | 2000 |
| Catechol-O-methyltransferase (COMT) in rat brain: immunoelectron microscopic study with an antiserum against rat recombinant COMT protein T Karhunen, C Tilgmann, I Ulmanen, P Panul Neuroscience letters 187 (1), 57-60, 1995 | 96 | 1995 |
| The enhanced contractility of the phospholamban-deficient mouse heart persists with aging JP Slack, IL Grupp, R Dash, D Holder, A Schmidt, MJ Gerst, T Tamura, ... Journal of molecular and cellular cardiology 33 (5), 1031-1040, 2001 | 79 | 2001 |
| The histamine H3-receptor: A target for developing new drugs U Bachrach, AK Saxena, M Saxena, R Leurs, H Timmerman, B Lee, ... Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrès des …, 1992 | 68 | 1992 |
| Expression of recombinant soluble and membrane‐bound catechol O‐methyltransferase in eukaryotic cells and identification of the respective enzymes in rat brain C Tilgmann, K Melen, K Lundström, A Jalanko, I Julkunen, N Kalkkinen, ... European journal of biochemistry 207 (2), 813-821, 1992 | 64 | 1992 |
| Purification methods of mammalian catechol-O-methyltransferases C Tilgmann, I Ulmanen Journal of Chromatography B: Biomedical Sciences and Applications 684 (1-2 …, 1996 | 59 | 1996 |
| A gas-pulsed-liquid-phase sequencer constructed from a Beckman 890D instrument by using Applied Biosystems delivery and cartridge blocks N Kalkkinen, C Tilgmann Journal of Protein Chemistry 7, 242, 1988 | 59 | 1988 |
| Purification and partial characterization of rat liver soluble catechol-O-methyltransferase C Tilgmann, N Kalkkinen FEBS letters 264 (1), 95-99, 1990 | 57 | 1990 |
| Expression of enzymatically active rat liver and human placental catechol-O-methyltransferase in Escherichia coli; purification and partial characterization of the enzyme K Lundström, C Tilgmann, J Peränen, N Kalkkinen, I Ulmanen Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression 1129 (2 …, 1992 | 56 | 1992 |
