Thomas Gonatopoulos-Pournatzis
Thomas Gonatopoulos-Pournatzis
NIH Stadtman Investigator
Verified email at - Homepage
Cited by
Cited by
Widespread intron retention in mammals functionally tunes transcriptomes
U Braunschweig, NL Barbosa-Morais, Q Pan, EN Nachman, B Alipanahi, ...
Genome research 24 (11), 1774-1786, 2014
A highly conserved program of neuronal microexons is misregulated in autistic brains
M Irimia, RJ Weatheritt, JD Ellis, NN Parikshak, ...
Cell 159 (7), 1511-1523, 2014
Cap-binding complex (CBC)
T Gonatopoulos-Pournatzis, VH Cowling
Biochemical Journal 457 (2), 231-242, 2014
An alternative splicing event amplifies evolutionary differences between vertebrates
S Gueroussov, T Gonatopoulos-Pournatzis, M Irimia, B Raj, ZY Lin, ...
Science 349 (6250), 868-873, 2015
Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors
H Han, U Braunschweig, T Gonatopoulos-Pournatzis, RJ Weatheritt, ...
Molecular Cell 65 (3), 539-553. e7, 2017
Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders
M Quesnel-Vallières, Z Dargaei, M Irimia, T Gonatopoulos-Pournatzis, ...
Molecular Cell 64 (6), 1023-1034, 2016
Genetic interaction mapping and exon-resolution functional genomics with a hybrid Cas9–Cas12a platform
T Gonatopoulos-Pournatzis, M Aregger, KR Brown, S Farhangmehr, ...
Nature Biotechnology, 1-11, 2020
Genome-wide CRISPR-Cas9 interrogation of splicing networks reveals a mechanism for recognition of autism-misregulated neuronal microexons
T Gonatopoulos-Pournatzis, M Wu, U Braunschweig, J Roth, H Han, ...
Molecular cell 72 (3), 510-524. e12, 2018
S-adenosyl homocysteine hydrolase is required for Myc-induced mRNA cap methylation, protein synthesis, and cell proliferation
ME Fernandez-Sanchez, T Gonatopoulos-Pournatzis, G Preston, ...
Molecular and cellular biology 29 (23), 6182-6191, 2009
RAM/Fam103a1 is required for mRNA cap methylation
T Gonatopoulos-Pournatzis, S Dunn, R Bounds, VH Cowling
Molecular cell 44 (4), 585-596, 2011
Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2
S Tahmasebi, SM Jafarnejad, IS Tam, T Gonatopoulos-Pournatzis, ...
Proceedings of the National Academy of Sciences 113 (44), 12360-12367, 2016
Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions
T Gonatopoulos-Pournatzis, R Niibori, EW Salter, RJ Weatheritt, B Tsang, ...
Molecular Cell, 2020
Microexons: at the nexus of nervous system development, behaviour and autism spectrum disorder
T Gonatopoulos-Pournatzis, BJ Blencowe
Current Opinion in Genetics & Development 65, 22-33, 2020
mRNA Cap Methylation in Pluripotency and Differentiation
L Grasso, O Suska, L Davidson, T Gonatopoulos-Pournatzis, ...
Cell Reports 16 (5), 1352-1365, 2016
Mechanisms of Neuronal Alternative Splicing and Strategies for Therapeutic Interventions
EJL Soto, MJ Gandal, T Gonatopoulos-Pournatzis, EA Heller, D Luo, ...
Journal of Neuroscience 39 (42), 8193-8199, 2019
RAM function is dependent on Kapβ2-mediated nuclear entry
T Gonatopoulos-Pournatzis, VH Cowling
Biochemical Journal 457 (3), 473-484, 2014
Application of CHyMErA Cas9-Cas12a combinatorial genome-editing platform for genetic interaction mapping and gene fragment deletion screening
M Aregger, K Xing, T Gonatopoulos-Pournatzis
Nature Protocols, 1-44, 2021
Analysis of combinatorial CRISPR screens with the Orthrus scoring pipeline
HN Ward, M Aregger, T Gonatopoulos-Pournatzis, M Billmann, ...
Nature Protocols, 1-33, 2021
Systematic exploration of dynamic splicing networks reveals conserved multistage regulators of neurogenesis
H Han, AJ Best, U Braunschweig, N Mikolajewicz, JD Li, J Roth, ...
Molecular Cell, 2022
Identification and functional characterisation of RAM, a novel and essential component of RNA guanine-7 methylation
T Gonatopoulos-Pournatzis
University of Dundee, 2012
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