High-level expression of a recombinant antibody from myeloma cells using a glutamine synthetase gene as an amplifiable selectable marker CR Bebbington, G Renner, S Thomson, D King, D Abrams, GT Yarranton Bio/technology 10 (2), 169-175, 1992 | 752 | 1992 |
Therapeutic antibody fragments with prolonged in vivo half-lives AP Chapman, P Antoniw, M Spitali, S West, S Stephens, DJ King Nature biotechnology 17 (8), 780-783, 1999 | 565 | 1999 |
A single amino acid substitution abolishes the heterogeneity of chimeric mouse/human (IgG4) antibody S Angal, DJ King, MW Bodmer, A Turner, ADG Lawson, G Roberts, ... Molecular immunology 30 (1), 105-108, 1993 | 479 | 1993 |
Heterogeneity of prostate-specific membrane antigen (PSMA) expression in prostate carcinoma with distant metastasis S Mannweiler, P Amersdorfer, S Trajanoski, JA Terrett, D King, G Mehes Pathology & Oncology Research 15, 167-172, 2009 | 445 | 2009 |
Comparative metabolism and retention of iodine-125, yttrium-90, and indium-111 radioimmunoconjugates by cancer cells OW Press, D Shan, J Howell-Clark, J Eary, FR Appelbaum, D Matthews, ... Cancer research 56 (9), 2123-2129, 1996 | 280 | 1996 |
Binding to CD20 by Anti-B1 Antibody or F(ab')2 is sufficient for induction of apoptosis in B-cell lines PM Cardarelli, M Quinn, D Buckman, Y Fang, D Colcher, DJ King, ... Cancer Immunology, Immunotherapy 51, 15-24, 2002 | 250 | 2002 |
Multimerization behaviour of single chain Fv variants for the tumour-binding antibody B72. 3 D Desplancq, DJ King, ADG Lawson, A Mountain Protein Engineering, Design and Selection 7 (8), 1027-1033, 1994 | 212 | 1994 |
Disulfide prodrugs and linkers and stabilizers useful therefor HP Ng, Z Li, DPC Mcgee, OL Saunders, G Wu, DJ King, V Martichonok, ... US Patent 6,989,452, 2006 | 207 | 2006 |
Molecular cloning of a human gastric lipase and expression of the enzyme in yeast MW Bodmer, S Angal, GT Yarranton, TJR Harris, A Lyons, DJ King, ... Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression 909 (3 …, 1987 | 200 | 1987 |
Pharmacokinetics and Immune Response of 131I-Chimeric Mouse/Human B72.3 (Human γ4) Monoclonal Antibody in Humans MB Khazaeli, MN Saleh, TP Liu, RF Meredith, RH Wheeler, TS Baker, ... Cancer research 51 (20), 5461-5466, 1991 | 171 | 1991 |
Improved tumor targeting with chemically cross-linked recombinant antibody fragments DJ King, A Turner, APH Farnsworth, JR Adair, RJ Owens, RB Pedley, ... Cancer research 54 (23), 6176-6185, 1994 | 163 | 1994 |
The use of UCOE vectors in combination with a preadapted serum free, suspension cell line allows for rapid production of large quantities of protein T Benton, T Chen, M McEntee, B Fox, D King, R Crombie, TC Thomas, ... Cytotechnology 38, 43-46, 2002 | 156 | 2002 |
Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies PM Bowers, RA Horlick, TY Neben, RM Toobian, GL Tomlinson, JL Dalton, ... Proceedings of the National Academy of Sciences 108 (51), 20455-20460, 2011 | 140 | 2011 |
Characterization and biodistribution of recombinant and recombinant/chimeric constructs of monoclonal antibody B72. 3 D Colcher, D Milenic, M Roselli, A Raubitschek, G Yarranton, D King, ... Cancer research 49 (7), 1738-1745, 1989 | 137 | 1989 |
Site-specific attachment to recombinant antibodies via introduced surface cysteine residues A Lyons, DJ King, RJ Owens, GT Yarranton, A Millican, NR Whittle, ... Protein Engineering, Design and Selection 3 (8), 703-708, 1990 | 124 | 1990 |
Preparation and preclinical evaluation of humanised A33 immunoconjugates for radioimmunotherapy DJ King, P Antoniw, RJ Owens, JR Adair, AMR Haines, APH Farnsworth, ... British journal of cancer 72 (6), 1364-1372, 1995 | 112 | 1995 |
Disulfide prodrugs and linkers and stabilizers useful therefor HP Ng, ZH Li, DPC Mcgee, OL Saunders, G Wu, DJ King, V Martichonok, ... US Patent 7,498,302, 2009 | 108 | 2009 |
A global Apollo programme to combat climate change D King, J Browne, R Layard, G O’Donnell, M Rees, N Stern, A Turner London School of Economics and Political Science, 2015 | 104 | 2015 |
Matrix-assisted UV-laser desorption/ionization mass spectrometric analysis of monoclonal antibodies for the determination of carbohydrate, conjugated chelator, and conjugated … MM Siegel, IJ Hollander, PR Hamann, JP James, L Hinman, BJ Smith, ... Analytical chemistry 63 (21), 2470-2481, 1991 | 103 | 1991 |
Expression, purification and characterization of a mouse-human chimeric antibody and chimeric Fab'fragment DJ King, JR Adair, S Angal, DC Low, KA Proudfoot, JC Lloyd, MW Bodmer, ... Biochemical Journal 281 (2), 317-323, 1992 | 97 | 1992 |