| Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance D Zatreanu, HMR Robinson, O Alkhatib, M Boursier, H Finch, L Geo, ... Nature communications 12 (1), 3636, 2021 | 226 | 2021 |
| Fragment-based hit identification: thinking in 3D AD Morley, A Pugliese, K Birchall, J Bower, P Brennan, N Brown, ... Drug Discovery Today 18 (23-24), 1221-1227, 2013 | 181 | 2013 |
| Enantioselective Baeyer–Villiger Oxidation Catalyzed by Palladium(II) Complexes with Chiral P,N-Ligands AV Malkov, F Friscourt, M Bell, ME Swarbrick, P Kocovský The Journal of Organic Chemistry 73 (11), 3996-4003, 2008 | 100 | 2008 |
| Alkyl Substituent Effects on Pipecolyl Amide Isomer Equilibrium: Efficient Methodology for Synthesizing Enantiopure 6-Alkylpipecolic Acids and Conformational Analysis of Their … ME Swarbrick, F Gosselin, WD Lubell The Journal of Organic Chemistry 64 (6), 1993-2002, 1999 | 70 | 1999 |
| MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression JRP Knight, C Alexandrou, GL Skalka, N Vlahov, K Pennel, L Officer, ... Cancer discovery 11 (5), 1228-1247, 2021 | 60 | 2021 |
| Synthesis and evaluation of 3-amino-6-aryl-pyridazines as selective CB2 agonists for the treatment of inflammatory pain RJ Gleave, PJ Beswick, AJ Brown, GMP Giblin, P Goldsmith, CP Haslam, ... Bioorganic & medicinal chemistry letters 20 (2), 465-468, 2010 | 56 | 2010 |
| The aza-[2, 3]-Wittig sigmatropic rearrangement of acyclic amines: Scope and limitations of silicon assistance JC Anderson, A Flaherty, ME Swarbrick The Journal of Organic Chemistry 65 (26), 9152-9156, 2000 | 44 | 2000 |
| Efficient nitrogen transfer from aldehyde-derived N-acyloxaziridines A Armstrong, ID Edmonds, ME Swarbrick Tetrahedron letters 44 (28), 5335-5338, 2003 | 40 | 2003 |
| Electrophilic amination of enolates with oxaziridines: effects of oxaziridine structure and reaction conditions A Armstrong, ID Edmonds, ME Swarbrick, NR Treweeke Tetrahedron 61 (35), 8423-8442, 2005 | 39 | 2005 |
| The Silicon-Assisted Aza-(2, 3)-Wittig Sigmatropic Rearrangement JC Anderson, DC Siddons, SC Smith, ME Swarbrick Journal of organic chemistry 61, 4820-4823, 1996 | 39 | 1996 |
| Potent, selective small molecule inhibitors of type III phosphatidylinositol-4-kinase α-but not β-inhibit the phosphatidylinositol signaling cascade and cancer cell proliferation MJ Waring, DM Andrews, PF Faulder, V Flemington, JC McKelvie, ... Chemical Communications 50 (40), 5388-5390, 2014 | 33 | 2014 |
| New monoterpene-derived phosphinopyridine ligands and their application in the enantioselective iridium-catalyzed hydrogenation G Chelucci, M Marchetti, AV Malkov, F Friscourt, ME Swarbrick, ... Tetrahedron 67 (30), 5421-5431, 2011 | 30 | 2011 |
| Identification of [4-[4-(methylsulfonyl) phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors ME Swarbrick, PJ Beswick, RJ Gleave, RH Green, S Bingham, C Bountra, ... Bioorganic & medicinal chemistry letters 19 (15), 4504-4508, 2009 | 23 | 2009 |
| Indole derivatives DA Demaine, GMP Giblin, RE Hosking, GGA Inglis, XQ Lewell, ... US Patent 7,288,564, 2007 | 21* | 2007 |
| Cox-2 inhibiting pyridine derivatives P Beswick, N Pegg, M Swarbrick, J Skidmore, S Modi US Patent 7,446,117, 2008 | 20 | 2008 |
| Discovery, characterization, and structure-based optimization of small-molecule in vitro and in vivo probes for human DNA polymerase theta ML Stockley, A Ferdinand, G Benedetti, P Blencowe, SM Boyd, M Calder, ... Journal of Medicinal Chemistry 65 (20), 13879-13891, 2022 | 19 | 2022 |
| Diastereoselective acyclic aza-[2, 3] Wittig sigmatropic rearrangements JC Anderson, SC Smith, ME Swarbrick Journal of the Chemical Society, Perkin Transactions 1, 1517-1522, 1997 | 18 | 1997 |
| Access to 3D Alicyclic Amine-Containing Fragments through Transannular C–H Arylation M Lee, A Adams, PB Cox, MS Sanford Synlett 30 (04), 417-422, 2019 | 17 | 2019 |
| 2-Amino-5-aryl-pyridines as selective CB2 agonists: Synthesis and investigation of structure–activity relationships RJ Gleave, PJ Beswick, AJ Brown, GMP Giblin, CP Haslam, D Livermore, ... Bioorganic & medicinal chemistry letters 19 (23), 6578-6581, 2009 | 17 | 2009 |
| Stereoconvergent approach for synthesizing enantiopure 5, 6‐dialkylpipecolic acids ME Swarbrick, WD Lubell Chirality: The Pharmacological, Biological, and Chemical Consequences of …, 2000 | 16 | 2000 |
