| Amino acid and glucose metabolism in fed‐batch CHO cell culture affects antibody production and glycosylation Y Fan, I Jimenez Del Val, C Müller, J Wagtberg Sen, SK Rasmussen, ... Biotechnology and bioengineering 112 (3), 521-535, 2015 | 223 | 2015 |
| Towards the implementation of quality by design to the production of therapeutic monoclonal antibodies with desired glycosylation patterns IJ Del Val, C Kontoravdi, JM Nagy Biotechnology progress 26 (6), 1505-1527, 2010 | 181 | 2010 |
| A dynamic mathematical model for monoclonal antibody N‐linked glycosylation and nucleotide sugar donor transport within a maturing Golgi apparatus I Jimenez del Val, JM Nagy, C Kontoravdi Biotechnology progress, 2011 | 140 | 2011 |
| Towards controlling the glycoform: a model framework linking extracellular metabolites to antibody glycosylation PM Jedrzejewski, IJ Del Val, A Constantinou, A Dell, SM Haslam, ... International journal of molecular sciences 15 (3), 4492-4522, 2014 | 92 | 2014 |
| A multi‐pronged investigation into the effect of glucose starvation and culture duration on fed‐batch CHO cell culture Y Fan, I Jimenez Del Val, C Müller, AM Lund, JW Sen, SK Rasmussen, ... Biotechnology and bioengineering 112 (10), 2172-2184, 2015 | 69 | 2015 |
| Model‐based optimization of antibody galactosylation in CHO cell culture P Kotidis, P Jedrzejewski, SN Sou, C Sellick, K Polizzi, IJ Del Val, ... Biotechnology and bioengineering 116 (7), 1612-1626, 2019 | 63 | 2019 |
| Dynamics of immature mAb glycoform secretion during CHO cell culture: An integrated modelling framework I Jimenez del Val, Y Fan, D Weilguny Biotechnology Journal 11 (5), 610-623, 2016 | 62 | 2016 |
| Moving towards an era of hybrid modelling: advantages and challenges of coupling mechanistic and data-driven models for upstream pharmaceutical bioprocesses A Tsopanoglou, IJ del Val Current Opinion in Chemical Engineering 32, 100691, 2021 | 57 | 2021 |
| An optimized method for extraction and quantification of nucleotides and nucleotide sugars from mammalian cells IJ del Val, S Kyriakopoulos, KM Polizzi, C Kontoravdi Analytical biochemistry 443 (2), 172-180, 2013 | 56 | 2013 |
| A theoretical estimate for nucleotide sugar demand towards Chinese Hamster Ovary cellular glycosylation IJ Del Val, KM Polizzi, C Kontoravdi Scientific Reports 6 (1), 28547, 2016 | 44 | 2016 |
| Metabolic network reconstruction: advances in in silico interpretation of analytical information N Chen, IJ del Val, S Kyriakopoulos, KM Polizzi, C Kontoravdi Current opinion in biotechnology 23 (1), 77-82, 2012 | 37 | 2012 |
| Global sensitivity analysis and meta-modeling of an ethanol production process E Todri, AN Amenaghawon, IJ Del Val, DJ Leak, C Kontoravdi, ... Chemical Engineering Science 114, 114-127, 2014 | 34 | 2014 |
| Integration of models and experimentation to optimise the production of potential biotherapeutics KE Royle, IJ del Val, C Kontoravdi Drug discovery today 18 (23-24), 1250-1255, 2013 | 33 | 2013 |
| Activity of NiW catalysts supported on TiO2-Al2O3 mixed oxides: Effect of Ti incorporation method on the HDS of 4, 6-DMDBT A Gutiérrez-Alejandre, J Ramírez, I Jiménez-del Val, M Peñuelas-Galaz, ... Catalysis today 107, 879-884, 2005 | 33 | 2005 |
| Synergising stoichiometric modelling with artificial neural networks to predict antibody glycosylation patterns in Chinese hamster ovary cells A Antonakoudis, B Strain, R Barbosa, IJ del Val, C Kontoravdi Computers & Chemical Engineering 154, 107471, 2021 | 29 | 2021 |
| Applying quality by design to glycoprotein therapeutics: experimental and computational efforts of process control PMJ Jedrzejewski, IJ del Val, KM Polizzi, C Kontoravdi Pharmaceutical Bioprocessing 1 (1), 51-69, 2013 | 28 | 2013 |
| Computational tools for predicting and controlling the glycosylation of biopharmaceuticals C Kontoravdi, IJ del Val Current opinion in chemical engineering 22, 89-97, 2018 | 18 | 2018 |
| Application of quality by design paradigm to the manufacture of protein therapeutics IJ del Val, PM Jedrzejewski, K Exley, SN Sou, S Kyriakopoulos, ... Glycosylation, 2012 | 15 | 2012 |
| Model-based operational optimisation of a microbial bioprocess converting terephthalic acid to biomass N Beagan, KE O’Connor, IJ Del Val Biochemical engineering journal 158, 107576, 2020 | 13 | 2020 |
| An integrated modular framework for modeling the effect of ammonium on the sialylation process of monoclonal antibodies produced by CHO cells ISP Savizi, E Motamedian, N E. Lewis, I Jimenez del Val, SA Shojaosadati Biotechnology Journal 16 (8), 2100019, 2021 | 9 | 2021 |
Cleo KontoravdiProfessor of Biological Systems Engineering, Imperial College LondonVerified email at imperial.ac.uk
