Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis MB Harbut, C Vilchèze, X Luo, ME Hensler, H Guo, B Yang, AK Chatterjee, ... Proceedings of the National Academy of Sciences 112 (14), 4453-4458, 2015 | 341 | 2015 |
Apicomplexan parasites co-opt host calpains to facilitate their escape from infected cells R Chandramohanadas, PH Davis, DP Beiting, MB Harbut, C Darling, ... science 324 (5928), 794-797, 2009 | 202 | 2009 |
Role for DNA polymerase κ in the processing of N2-N2-guanine interstrand cross-links IG Minko, MB Harbut, ID Kozekov, A Kozekova, PM Jakobs, SB Olson, ... Journal of Biological Chemistry 283 (25), 17075-17082, 2008 | 160 | 2008 |
Bestatin-based chemical biology strategy reveals distinct roles for malaria M1-and M17-family aminopeptidases MB Harbut, G Velmourougane, S Dalal, G Reiss, JC Whisstock, O Onder, ... Proceedings of the National Academy of Sciences 108 (34), E526-E534, 2011 | 158 | 2011 |
Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design MB Harbut, BA Patel, BKS Yeung, CW McNamara, AT Bright, J Ballard, ... Proceedings of the National Academy of Sciences 109 (52), 21486-21491, 2012 | 114 | 2012 |
Synthesis of new (−)-bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase G Velmourougane, MB Harbut, S Dalal, S McGowan, CA Oellig, ... Journal of medicinal chemistry 54 (6), 1655-1666, 2011 | 88 | 2011 |
Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB JP Mallari, AA Shelat, T Obrien, CR Caffrey, A Kosinski, M Connelly, ... Journal of Medicinal Chemistry 51 (3), 545-552, 2008 | 71 | 2008 |
Replication bypass of interstrand cross-link intermediates by Escherichia coli DNA polymerase IV A Kumari, IG Minko, MB Harbut, SE Finkel, MF Goodman, RS Lloyd Journal of Biological Chemistry 283 (41), 27433-27437, 2008 | 63 | 2008 |
Small molecules targeting Mycobacterium tuberculosis type II NADH dehydrogenase exhibit antimycobacterial activity MB Harbut, B Yang, R Liu, T Yano, C Vilchèze, B Cheng, J Lockner, ... Angewandte Chemie 130 (13), 3536-3540, 2018 | 62 | 2018 |
Determinants of the inhibition of DprE1 and CYP2C9 by antitubercular thiophenes R Liu, X Lyu, SM Batt, MH Hsu, MB Harbut, C Vilchèze, B Cheng, K Ajayi, ... Angewandte Chemie International Edition 56 (42), 13011-13015, 2017 | 50 | 2017 |
Selective BET bromodomain inhibition as an antifungal therapeutic strategy. F Mietton, EF Ferri, M Champleboux, N Zala, D Maubon, Y Zhou, ... Nature Communications 8 (15482), 2017 | 46 | 2017 |
Development of bestatin-based activity-based probes for metallo-aminopeptidases MB Harbut, G Velmourougane, G Reiss, R Chandramohanadas, ... Bioorganic & medicinal chemistry letters 18 (22), 5932-5936, 2008 | 42 | 2008 |
Replication Bypass of N2-Deoxyguanosine Interstrand Cross-Links by Human DNA Polymerases η and ι AR Klug, MB Harbut, RS Lloyd, IG Minko Chemical research in toxicology 25 (3), 755-762, 2012 | 38 | 2012 |
Identification of small-molecule protein–protein interaction inhibitors for NKG2D AA Thompson, MB Harbut, PP Kung, NK Karpowich, JD Branson, ... Proceedings of the National Academy of Sciences 120 (18), e2216342120, 2023 | 7 | 2023 |
Modulation of the turnover of formamidopyrimidine DNA glycosylase MB Harbut, M Meador, ML Dodson, RS Lloyd Biochemistry 45 (23), 7341-7346, 2006 | 2 | 2006 |
Diastereoselective Synthesis of (–)-Bestatin, Epibestatin, Phebestin and (3S, 4R)-4-Amino-3-hydroxy-5-phenylpentanoic Acid from an Aldehyde Derived from d-Phenylalanine VK Jain SynOpen 3 (04), 114-123, 2019 | 1 | 2019 |
Chemical Genetic Approaches for Elucidating Protease Function and Drug-Target Potential in Plasmodium Falciparum MB Harbut University of Pennsylvania, 2012 | | 2012 |
Bypass of N-2-Deoxyguanosine Interstrand Cross-Links by Human DNA Polymerase Eta IG Minko, AR Klug, MB Harbut, RS Lloyd ENVIRONMENTAL AND MOLECULAR MUTAGENESIS 51 (7), 713-713, 2010 | | 2010 |