Dheeraj Tomar
Dheeraj Tomar
Senior Scientist, Protein Engineering at Xilio Therapeutics, Inc.
Verified email at jhu.edu - Homepage
Cited by
Cited by
Molecular basis of high viscosity in concentrated antibody solutions: strategies for high concentration drug product development
DS Tomar, S Kumar, SK Singh, S Goswami, L Li
MAbs 8 (2), 216-228, 2016
Characterization and higher-order structure assessment of an interchain cysteine-based ADC: impact of drug loading and distribution on the mechanism of aggregation
J Guo, S Kumar, M Chipley, O Marcq, D Gupta, Z Jin, DS Tomar, ...
Bioconjugate chemistry 27 (3), 604-615, 2016
In-silico prediction of concentration-dependent viscosity curves for monoclonal antibody solutions
DS Tomar, L Li, MP Broulidakis, NG Luksha, CT Burns, SK Singh, ...
MAbs 9 (3), 476-489, 2017
Intramolecular Interactions Overcome Hydration to Drive the Collapse Transition of Gly15
D Asthagiri, D Karandur, DS Tomar, BM Pettitt
The Journal of Physical Chemistry B 121 (34), 8078-8084, 2017
Importance of hydrophilic hydration and intramolecular interactions in the thermodynamics of helix–coil transition and helix–helix assembly in a deca-alanine peptide
DS Tomar, V Weber, BM Pettitt, D Asthagiri
The Journal of Physical Chemistry B 120 (1), 69-76, 2016
Adsorption of dichloromethane on activated carbon
C Borkar, D Tomar, S Gumma
Journal of Chemical & Engineering Data 55 (4), 1640-1644, 2010
In silico prediction of diffusion interaction parameter (k D), a key indicator of antibody solution behaviors
DS Tomar, SK Singh, L Li, MP Broulidakis, S Kumar
Pharmaceutical research 35 (10), 1-20, 2018
Solvation free energy of the peptide group: its model dependence and implications for the additive-transfer free-energy model of protein stability
DS Tomar, D Asthagiri, V Weber
Biophysical journal 105 (6), 1482-1490, 2013
Conditional solvation thermodynamics of isoleucine in model peptides and the limitations of the group-transfer model
DS Tomar, V Weber, BM Pettitt, D Asthagiri
The Journal of Physical Chemistry B 118 (15), 4080-4087, 2014
Rational optimization of a monoclonal antibody for simultaneous improvements in its solution properties and biological activity
S Kumar, K Roffi, DS Tomar, D Cirelli, N Luksha, D Meyer, J Mitchell, ...
Protein Engineering, Design and Selection 31 (7-8), 313-325, 2018
Potential parameters for helium adsorption in silicalite
DS Tomar, M Singla, S Gumma
Microporous and mesoporous materials 142 (1), 116-121, 2011
Solvophobic and solvophilic contributions in the water-to-aqueous guanidinium chloride transfer free energy of model peptides
DS Tomar, N Ramesh, D Asthagiri
The Journal of chemical physics 148 (22), 222822, 2018
Hydrophilic Interactions Dominate the Inverse Temperature Dependence of Polypeptide Hydration Free Energies Attributed to Hydrophobicity
DS Tomar, ME Paulaitis, LR Pratt, DN Asthagiri
The Journal of Physical Chemistry Letters 11 (22), 9965-9970, 2020
System size dependence of Hydration-Shell occupancy and its implications for assessing the hydrophobic and hydrophilic contributions to hydration
D Asthagiri, DS Tomar
The Journal of Physical Chemistry B 124 (5), 798-806, 2020
Stress-dependent flexibility of a full-length human monoclonal antibody: Insights from molecular dynamics to support biopharmaceutical development
DS Tomar, G Licari, J Bauer, SK Singh, L Li, S Kumar
Journal of Pharmaceutical Sciences, 2021
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