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Timothy Sheahan
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Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV
TP Sheahan, AC Sims, SR Leist, A Schäfer, J Won, AJ Brown, ...
Nature communications 11 (1), 222, 2020
21372020
Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses
TP Sheahan, AC Sims, RL Graham, VD Menachery, LE Gralinski, ...
Science translational medicine 9 (396), eaal3653, 2017
18272017
Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease
ML Agostini, EL Andres, AC Sims, RL Graham, TP Sheahan, X Lu, ...
MBio 9 (2), 10.1128/mbio. 00221-18, 2018
13902018
An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice
TP Sheahan, AC Sims, S Zhou, RL Graham, AJ Pruijssers, ML Agostini, ...
Science translational medicine 12 (541), eabb5883, 2020
10662020
A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures
KH Dinnon III, SR Leist, A Schäfer, CE Edwards, DR Martinez, ...
Nature 586 (7830), 560-566, 2020
6472020
Complement activation contributes to severe acute respiratory syndrome coronavirus pathogenesis
LE Gralinski, TP Sheahan, TE Morrison, VD Menachery, K Jensen, ...
MBio 9 (5), 10.1128/mbio. 01753-18, 2018
5982018
Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase
AJ Brown, JJ Won, RL Graham, KH Dinnon III, AC Sims, JY Feng, T Cihlar, ...
Antiviral research 169, 104541, 2019
5592019
A mouse-adapted SARS-CoV-2 induces acute lung injury and mortality in standard laboratory mice
SR Leist, KH Dinnon, A Schäfer, VT Longping, K Okuda, YJ Hou, A West, ...
Cell 183 (4), 1070-1085. e12, 2020
4822020
Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice
AJ Pruijssers, AS George, A Schäfer, SR Leist, LE Gralinksi, KH Dinnon, ...
Cell reports 32 (3), 2020
4772020
SARS-like WIV1-CoV poised for human emergence
VD Menachery, BL Yount Jr, AC Sims, K Debbink, SS Agnihothram, ...
Proceedings of the National Academy of Sciences 113 (11), 3048-3053, 2016
4472016
Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2
AC Walls, B Fiala, A Schäfer, S Wrenn, MN Pham, M Murphy, ...
Cell 183 (5), 1367-1382. e17, 2020
4452020
Vaccine efficacy in senescent mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variants
D Deming, T Sheahan, M Heise, B Yount, N Davis, A Sims, M Suthar, ...
PLoS medicine 3 (12), e525, 2006
3212006
Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice
MM Becker, RL Graham, EF Donaldson, B Rockx, AC Sims, T Sheahan, ...
Proceedings of the National Academy of Sciences 105 (50), 19944-19949, 2008
3172008
Small-Molecule Antiviral β-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance
ML Agostini, AJ Pruijssers, JD Chappell, J Gribble, X Lu, EL Andres, ...
Journal of virology 93 (24), 10.1128/jvi. 01348-19, 2019
3102019
Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo
A Schäfer, F Muecksch, JCC Lorenzi, SR Leist, M Cipolla, S Bournazos, ...
Journal of Experimental Medicine 218 (3), e20201993, 2020
3032020
A phase 2a clinical trial of molnupiravir in patients with COVID-19 shows accelerated SARS-CoV-2 RNA clearance and elimination of infectious virus
WA Fischer, JJ Eron Jr, W Holman, MS Cohen, L Fang, LJ Szewczyk, ...
Science translational medicine 14 (628), eabl7430, 2021
2842021
β-d-N4-hydroxycytidine Inhibits SARS-CoV-2 Through Lethal Mutagenesis But Is Also Mutagenic To Mammalian Cells
S Zhou, CS Hill, S Sarkar, LV Tse, BMD Woodburn, RF Schinazi, ...
The Journal of infectious diseases 224 (3), 415-419, 2021
2842021
Genomic RNA elements drive phase separation of the SARS-CoV-2 nucleocapsid
C Iserman, CA Roden, MA Boerneke, RSG Sealfon, GA McLaughlin, ...
Molecular cell 80 (6), 1078-1091. e6, 2020
2592020
Modeling hepatitis C virus infection using human induced pluripotent stem cells
RE Schwartz, K Trehan, L Andrus, TP Sheahan, A Ploss, SA Duncan, ...
Proceedings of the National Academy of Sciences 109 (7), 2544-2548, 2012
2532012
Molnupiravir, an oral antiviral treatment for COVID-19
W Fischer, JJ Eron Jr, W Holman, MS Cohen, L Fang, LJ Szewczyk, ...
MedRxiv, 2021.06. 17.21258639, 2021
2262021
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