Rona Graham
Rona Graham
Assistant Professor, University of Sherbrooke
Verified email at usherbrooke.ca - Homepage
TitleCited byYear
The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease
SE Andrew, YP Goldberg, B Kremer, H Telenius, J Theilmann, S Adam, ...
Nature genetics 4 (4), 398, 1993
11041993
The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease
SE Andrew, YP Goldberg, B Kremer, H Telenius, J Theilmann, S Adam, ...
Nature genetics 4 (4), 398, 1993
10991993
Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease
EJ Slow, J Van Raamsdonk, D Rogers, SH Coleman, RK Graham, ...
Human molecular genetics 12 (13), 1555-1567, 2003
6962003
Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract
YP Goldberg, DW Nicholson, DM Rasper, MA Kalchman, HB Koide, ...
Nature genetics 13 (4), 442, 1996
6931996
Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin
RK Graham, Y Deng, EJ Slow, B Haigh, N Bissada, G Lu, J Pearson, ...
Cell 125 (6), 1179-1191, 2006
6452006
Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms
M Saleh, JP Vaillancourt, RK Graham, M Huyck, SM Srinivasula, ...
Nature 429 (6987), 75, 2004
4442004
Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice
AJ Milnerwood, CM Gladding, MA Pouladi, AM Kaufman, RM Hines, ...
Neuron 65 (2), 178-190, 2010
3972010
HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain
MA Kalchman, HB Koide, K McCutcheon, RK Graham, K Nichol, ...
Nature genetics 16 (1), 44, 1997
3971997
Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease
CL Wellington, LM Ellerby, CA Gutekunst, D Rogers, S Warby, ...
Journal of Neuroscience 22 (18), 7862-7872, 2002
3802002
Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme
MA Kalchman, RK Graham, G Xia, HB Koide, JG Hodgson, KC Graham, ...
Journal of Biological Chemistry 271 (32), 19385-19394, 1996
3711996
Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin
S Okamoto, MA Pouladi, M Talantova, D Yao, P Xia, DE Ehrnhoefer, ...
Nature medicine 15 (12), 1407, 2009
3682009
Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions
EJ Slow, RK Graham, AP Osmand, RS Devon, G Lu, Y Deng, J Pearson, ...
Proceedings of the National Academy of Sciences 102 (32), 11402-11407, 2005
2972005
Molecular analysis of new mutations for Huntington's disease: intermediate alleles and sex of origin effects
YP Goldberg, B Kremer, SE Andrew, J Theilmann, RK Graham, F Squitieri, ...
Nature genetics 5 (2), 174, 1993
2761993
Wild‐type huntingtin protects neurons from excitotoxicity
BR Leavitt, JM van Raamsdonk, J Shehadeh, H Fernandes, Z Murphy, ...
Journal of neurochemistry 96 (4), 1121-1129, 2006
1932006
Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin
MA Pouladi, RK Graham, JM Karasinska, Y Xie, RD Santos, ┼ PetersÚn, ...
Brain 132 (4), 919-932, 2009
1392009
Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice
P Guidetti, GP Bates, RK Graham, MR Hayden, BR Leavitt, ...
Neurobiology of disease 23 (1), 190-197, 2006
1352006
Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease
J Shehadeh, HB Fernandes, MMZ Mullins, RK Graham, BR Leavitt, ...
Neurobiology of disease 21 (2), 392-403, 2006
1322006
Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus
SC Warby, CN Doty, RK Graham, JB Carroll, YZ Yang, RR Singaraja, ...
Human molecular genetics 17 (15), 2390-2404, 2008
1252008
Absence of disease phenotype and intergenerational stability of the CAG repeat in transgenic mice expressing the human Huntington disease transcript
YP Goldberg, MA Kalchman, M Metzler, J Nasir, J Zeisler, R Graham, ...
Human molecular genetics 5 (2), 177-185, 1996
1201996
Mutant huntingtin N-terminal fragments of specific size mediate aggregation and toxicity in neuronal cells
T Ratovitski, M Gucek, H Jiang, E Chighladze, E Waldron, J D'Ambola, ...
Journal of Biological Chemistry 284 (16), 10855-10867, 2009
1192009
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