Victor N Uebele
Victor N Uebele
Director, Small Molecule Secreening, Merck
Verified email at merck.com
Title
Cited by
Cited by
Year
Cloning and functional expression of two families of β-subunits of the large conductance calcium-activated K+ channel
VN Uebele, A Lagrutta, T Wade, DJ Figueroa, Y Liu, E McKenna, ...
Journal of Biological Chemistry 275 (30), 23211-23218, 2000
2572000
Selective T-type calcium channel block in thalamic neurons reveals channel redundancy and physiological impact of ITwindow
FM Dreyfus, A Tscherter, AC Errington, JJ Renger, HS Shin, VN Uebele, ...
The Journal of Neuroscience 30 (1), 99-109, 2010
1742010
Characterization of a voltage-gated K+ channel beta subunit expressed in human heart
SK England, VN Uebele, H Shear, J Kodali, PB Bennett, MM Tamkun
Proceedings of the National Academy of Sciences 92 (14), 6309-6313, 1995
1601995
Presynaptic HCN1 channels regulate Cav3. 2 activity and neurotransmission at select cortical synapses
Z Huang, R Lujan, I Kadurin, VN Uebele, JJ Renger, AC Dolphin, ...
Nature neuroscience 14 (4), 478-486, 2011
1542011
High throughput ion-channel pharmacology: planar-array-based voltage clamp
L Kiss, PB Bennett, VN Uebele, KS Koblan, SA Kane, B Neagle, ...
Assay and drug development technologies 1 (1, Supplement 2), 127-135, 2003
1542003
A novel K+ channel β-subunit (hKvβ1. 3) is produced via alternative mRNA splicing
SK England, VN Uebele, J Kodali, PB Bennett, MM Tamkun
Journal of Biological Chemistry 270 (48), 28531-28534, 1995
1491995
Molecular Analysis of a Binding Site for Quinidine in a Human Cardiac Delayed Rectifier K+ Channel Role of S6 in Antiarrhythmic Drug Binding
SW Yeola, TC Rich, VN Uebele, MM Tamkun, DJ Snyders
Circulation Research 78 (6), 1105-1114, 1996
1481996
Functional differences in Kv1. 5 currents expressed in mammalian cell lines are due to the presence of endogenous Kvβ2. 1 subunits
VN Uebele, SK England, A Chaudhary, MM Tamkun, DJ Snyders
Journal of Biological Chemistry 271 (5), 2406-2412, 1996
1481996
Essential thalamic contribution to slow waves of natural sleep
F David, JT Schmiedt, HL Taylor, G Orban, G Di Giovanni, VN Uebele, ...
The Journal of Neuroscience 33 (50), 19599-19610, 2013
1452013
Presynaptic Cav3. 2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons
MO Jacus, VN Uebele, JJ Renger, SM Todorovic
The Journal of Neuroscience 32 (27), 9374-9382, 2012
1252012
Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonist
WD Shipe, JC Barrow, ZQ Yang, CW Lindsley, FV Yang, KAS Schlegel, ...
Journal of medicinal chemistry 51 (13), 3692-3695, 2008
1142008
Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure
CJ Winrow, KQ Tanis, DR Reiss, AM Rigby, JM Uslaner, VN Uebele, ...
Neuropharmacology 58 (1), 185-194, 2010
982010
In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice
RL Kraus, Y Li, Y Gregan, AL Gotter, VN Uebele, SV Fox, SM Doran, ...
Journal of Pharmacology and Experimental Therapeutics 335 (2), 409-417, 2010
942010
State-dependent properties of a new T-type calcium channel blocker enhance Ca V 3.2 selectivity and support analgesic effects
A Francois, N Kerckhove, M Meleine, A Alloui, C Barrere, A Gelot, ...
Pain 154 (2), 283-293, 2013
852013
Discovery of 1, 4-substituted piperidines as potent and selective inhibitors of T-type calcium channels
ZQ Yang, JC Barrow, WD Shipe, KAS Schlegel, Y Shu, FV Yang, ...
Journal of medicinal chemistry 51 (20), 6471-6477, 2008
842008
Calcineurin signaling mediates activity-dependent relocation of the axon initial segment
MD Evans, RP Sammons, S Lebron, AS Dumitrescu, TBK Watkins, ...
The Journal of Neuroscience 33 (16), 6950-6963, 2013
832013
Nerve terminal nicotinic acetylcholine receptors initiate quantal GABA release from perisomatic interneurons by activating axonal T-type (Cav3) Ca2+ channels and Ca2+ release …
AH Tang, MA Karson, DA Nagode, JM McIntosh, VN Uebele, JJ Renger, ...
The Journal of Neuroscience 31 (38), 13546-13561, 2011
822011
Antagonism of T-type calcium channels inhibits high-fat diet–induced weight gain in mice
VN Uebele, AL Gotter, CE Nuss, RL Kraus, SM Doran, SL Garson, ...
The Journal of clinical investigation 119 (6), 1659-1667, 2009
802009
Biphasic cholinergic synaptic transmission controls action potential activity in thalamic reticular nucleus neurons
YG Sun, JD Pita-Almenar, CS Wu, JJ Renger, VN Uebele, HC Lu, ...
The Journal of Neuroscience 33 (5), 2048-2059, 2013
682013
Positive allosteric interaction of structurally diverse T-type calcium channel antagonists
VN Uebele, CE Nuss, SV Fox, SL Garson, R Cristescu, SM Doran, ...
Cell biochemistry and biophysics 55 (2), 81-93, 2009
612009
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