sean ekins
sean ekins
Collaborations Pharmaceuticals Inc
Verified email at collaborationspharma.com - Homepage
TitleCited byYear
In silico pharmacology for drug discovery: methods for virtual ligand screening and profiling
S Ekins, J Mestres, B Testa
British journal of pharmacology 152 (1), 9-20, 2007
4052007
Pharmacophore and three-dimensional quantitative structure activity relationship methods for modeling cytochrome p450 active sites
S Ekins, MJ de Groot, JP Jones
Drug Metabolism and Disposition 29 (7), 936-944, 2001
2862001
Progress in predicting human ADME parameters in silico
S Ekins, CL Waller, PW Swaan, G Cruciani, SA Wrighton, JH Wikel
Journal of pharmacological and toxicological methods 44 (1), 251-272, 2000
2862000
In silico pharmacology for drug discovery: applications to targets and beyond
S Ekins, J Mestres, B Testa
British journal of pharmacology 152 (1), 21-37, 2007
2812007
Three-dimensional quantitative structure-activity relationship for inhibition of human ether-a-go-go-related gene potassium channel
S Ekins, WJ Crumb, RD Sarazan, JH Wikel, SA Wrighton
Journal of Pharmacology and Experimental Therapeutics 301 (2), 427-434, 2002
2772002
Pathway mapping tools for analysis of high content data
S Ekins, Y Nikolsky, A Bugrim, E Kirillov, T Nikolskaya
High Content Screening, 319-350, 2007
2732007
Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates
S Ekins, RB Kim, BF Leake, AH Dantzig, EG Schuetz, LB Lan, K Yasuda, ...
Molecular pharmacology 61 (5), 974-981, 2002
2322002
Present and future in vitro approaches for drug metabolism
S Ekins, BJ Ring, J Grace, DJ McRobie-Belle, SA Wrighton
Journal of pharmacological and toxicological methods 44 (1), 313-324, 2000
2312000
In silico repositioning of approved drugs for rare and neglected diseases
S Ekins, AJ Williams, MD Krasowski, JS Freundlich
Drug discovery today 16 (7-8), 298-310, 2011
2132011
Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein
S Ekins, RB Kim, BF Leake, AH Dantzig, EG Schuetz, LB Lan, K Yasuda, ...
Molecular pharmacology 61 (5), 964-973, 2002
2112002
The role of CYP2B6 in human xenobiotic metabolism
S EKINS, SA WRIGHTON
Drug metabolism reviews 31 (3), 719-754, 1999
2051999
Techniques: application of systems biology to absorption, distribution, metabolism, excretion and toxicity
S Ekins, Y Nikolsky, T Nikolskaya
Trends in pharmacological sciences 26 (4), 202-209, 2005
2002005
Further characterization of the expression in liver and catalytic activity of CYP2B6
S Ekins, M Vandenbranden, BJ Ring, JS Gillespie, TJ Yang, HV Gelboin, ...
Journal of Pharmacology and Experimental Therapeutics 286 (3), 1253-1259, 1998
1951998
A pharmacophore for human pregnane X receptor ligands
S Ekins, JA Erickson
Drug Metabolism and Disposition 30 (1), 96-99, 2002
1892002
Design, synthesis, cytoselective toxicity, structure–activity relationships, and pharmacophore of thiazolidinone derivatives targeting drug-resistant lung cancer cells
H Zhou, S Wu, S Zhai, A Liu, Y Sun, R Li, Y Zhang, S Ekins, PW Swaan, ...
Journal of medicinal chemistry 51 (5), 1242-1251, 2008
1872008
In vitro and pharmacophore insights into CYP3A enzymes
S Ekins, DM Stresser, JA Williams
Trends in pharmacological sciences 24 (4), 161-166, 2003
1762003
Three-and four-dimensional quantitative structure activity relationship analyses of cytochrome P-450 3A4 inhibitors
S Ekins, G Bravi, S Binkley, JS Gillespie, BJ Ring, JH Wikel, SA Wrighton
Journal of Pharmacology and Experimental Therapeutics 290 (1), 429-438, 1999
1721999
Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates
S Ekins, G Bravi, JH Wikel, SA Wrighton
Journal of Pharmacology and Experimental Therapeutics 291 (1), 424-433, 1999
1711999
Three-and four-dimensional-quantitative structure activity relationship (3D/4D-QSAR) analyses of CYP2C9 inhibitors
S Ekins, G Bravi, S Binkley, JS Gillespie, BJ Ring, JH Wikel, SA Wrighton
Drug Metabolism and Disposition 28 (8), 994-1002, 2000
1652000
Predicting undesirable drug interactions with promiscuous proteins in silico
S Ekins
Drug discovery today 9 (6), 276-285, 2004
1602004
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