Matthew Sale
Matthew Sale
Verified email at babraham.ac.uk
TitleCited byYear
MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road
CJ Caunt, MJ Sale, PD Smith, SJ Cook
Nature Reviews Cancer 15 (10), 577, 2015
2332015
Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells
AS Little, K Balmanno, MJ Sale, S Newman, JR Dry, M Hampson, ...
Sci. Signal. 4 (166), ra17-ra17, 2011
1712011
Adaptation to mTOR kinase inhibitors by amplification of eIF4E to maintain cap-dependent translation
CL Cope, R Gilley, K Balmanno, MJ Sale, KD Howarth, M Hampson, ...
J Cell Sci 127 (4), 788-800, 2014
692014
The BH3 mimetic ABT-263 synergizes with the MEK1/2 inhibitor selumetinib/AZD6244 to promote BIM-dependent tumour cell death and inhibit acquired resistance
MJ Sale, SJ Cook
Biochemical Journal 450 (2), 285-294, 2013
462013
Control of cell death and mitochondrial fission by ERK 1/2 MAP kinase signalling
SJ Cook, K Stuart, R Gilley, MJ Sale
The FEBS journal 284 (24), 4177-4195, 2017
272017
Lysine acetylation controls local protein conformation by influencing proline isomerization
FS Howe, I Boubriak, MJ Sale, A Nair, D Clynes, A Grijzenhout, ...
Molecular cell 55 (5), 733-744, 2014
242014
Intrinsic and acquired resistance to MEK1/2 inhibitors in cancer
MJ Sale, SJ Cook
Biochemical Society Transactions 42 (4), 776-783, 2014
192014
That which does not kill me makes me stronger; combining ERK 1/2 pathway inhibitors and BH 3 mimetics to kill tumour cells and prevent acquired resistance
MJ Sale, SJ Cook
British journal of pharmacology 169 (8), 1708-1722, 2013
172013
Tumour cell responses to MEK1/2 inhibitors: acquired resistance and pathway remodelling
AS Little, K Balmanno, MJ Sale, PD Smith, SJ Cook
Biochemical Society Transactions 40 (1), 73-78, 2012
162012
A correction to the research article titled:" Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells …
AS Little, K Balmanno, MJ Sale, S Newman, JR Dry, M Hampson, ...
Science signaling 4 (170), er2-er2, 2011
52011
The increase in BIK expression following ERK1/2 pathway inhibition is a consequence of G1 cell-cycle arrest and not a direct effect on BIK protein stability
MJ Sale, SJ Cook
Biochemical Journal 459 (3), 513-524, 2014
22014
Targeting melanoma’s MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors
MJ Sale, E Minihane, NR Monks, R Gilley, FM Richards, KP Schifferli, ...
Nature Publishing Group, 2019
2019
MEK1/2 inhibitor withdrawal reverses acquired resistance driven by BRAF V600E amplification whereas KRAS G13D amplification promotes EMT-chemoresistance
MJ Sale, K Balmanno, J Saxena, E Ozono, K Wojdyla, RE McIntyre, ...
Nature communications 10 (1), 2030, 2019
2019
Resistance to ERK1/2 pathway inhibitors; sweet spots, fitness deficits and drug addiction
MJ Sale, K Balmanno, SJ Cook
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