|Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis|
H Shao, LC Burrage, DS Sinasac, AE Hill, SR Ernest, W O'Brien, ...
Proceedings of the National Academy of Sciences 105 (50), 19910-19914, 2008
|IGF‐1 and bone: new discoveries from mouse models|
S Yakar, HW Courtland, D Clemmons
Journal of Bone and Mineral Research 25 (12), 2543-2552, 2010
|Serum IGF‐1 determines skeletal strength by regulating subperiosteal expansion and trait interactions|
S Yakar, E Canalis, H Sun, W Mejia, Y Kawashima, P Nasser, ...
Journal of Bone and Mineral Research 24 (8), 1481-1492, 2009
|Genetic randomization reveals functional relationships among morphologic and tissue-quality traits that contribute to bone strength and fragility|
KJ Jepsen, B Hu, SM Tommasini, HW Courtland, C Price, CJ Terranova, ...
Mammalian genome 18 (6-7), 492-507, 2007
|Measuring the dynamic mechanical response of hydrated mouse bone by nanoindentation|
S Pathak, JG Swadener, SR Kalidindi, HW Courtland, KJ Jepsen, ...
Journal of the mechanical behavior of biomedical materials 4 (1), 34-43, 2011
|Elevated serum levels of IGF‐1 are sufficient to establish normal body size and skeletal properties even in the absence of tissue IGF‐1|
S Elis, HW Courtland, Y Wu, CJ Rosen, H Sun, KJ Jepsen, RJ Majeska, ...
Journal of Bone and Mineral Research 25 (6), 1257-1266, 2010
|Defining nasal cartilage elasticity: biomechanical testing of the tripod theory based on a cantilevered model|
RW Westreich, HW Courtland, P Nasser, K Jepsen, W Lawson
Archives of Facial Plastic Surgery 9 (4), 264-270, 2007
|Serum IGF-1 affects skeletal acquisition in a temporal and compartment-specific manner|
HW Courtland, S Elis, Y Wu, H Sun, CJ Rosen, KJ Jepsen, S Yakar
PloS one 6 (3), e14762, 2011
|Fourier transform infrared imaging microspectroscopy and tissue-level mechanical testing reveal intraspecies variation in mouse bone mineral and matrix composition|
HW Courtland, P Nasser, AB Goldstone, L Spevak, AL Boskey, KJ Jepsen
Calcified tissue international 83 (5), 342, 2008
|Phenotypic integration of skeletal traits during growth buffers genetic variants affecting the slenderness of femora in inbred mouse strains|
KJ Jepsen, B Hu, SM Tommasini, HW Courtland, C Price, M Cordova, ...
Mammalian Genome 20 (1), 21, 2009
|Growth hormone mediates pubertal skeletal development independent of hepatic IGF‐1 production|
HW Courtland, H Sun, M Beth‐On, Y Wu, S Elis, CJ Rosen, S Yakar
Journal of bone and mineral research 26 (4), 761-768, 2011
|Elevated serum IGF‐1 levels synergize PTH action on the skeleton only when the tissue IGF‐1 axis is intact|
S Elis, HW Courtland, Y Wu, JC Fritton, H Sun, CJ Rosen, S Yakar
Journal of Bone and Mineral Research 25 (9), 2051-2058, 2010
|Low levels of plasma IGF-1 inhibit intracortical bone remodeling during aging|
HW Courtland, OD Kennedy, Y Wu, Y Gao, H Sun, MB Schaffler, S Yakar
Age 35 (5), 1691-1703, 2013
|Sex‐specific regulation of body size and bone slenderness by the acid labile subunit|
HW Courtland, V DeMambro, J Maynard, H Sun, S Elis, C Rosen, S Yakar
Journal of Bone and Mineral Research 25 (9), 2059-2068, 2010
|Unbound (bioavailable) IGF1 enhances somatic growth|
S Elis, Y Wu, HW Courtland, D Cannata, H Sun, M Beth-On, C Liu, ...
Disease models & mechanisms 4 (5), 649-658, 2011
|Genetically determined phenotype covariation networks control bone strength|
KJ Jepsen, HW Courtland, JH Nadeau
Journal of Bone and Mineral Research 25 (7), 1581-1593, 2010
|Increased serum IGF‐1 levels protect the musculoskeletal system but are associated with elevated oxidative stress markers and increased mortality independent of tissue igf1 …|
S Elis, YJ Wu, HW Courtland, H Sun, CJ Rosen, ML Adamo, S Yakar
Aging cell 10 (3), 547-550, 2011
|The insulin-like growth factor-1 binding protein acid-labile subunit alters mesenchymal stromal cell fate|
JC Fritton, Y Kawashima, W Mejia, HW Courtland, S Elis, H Sun, Y Wu, ...
Journal of Biological Chemistry 285 (7), 4709-4714, 2010
|Intermittent PTH administration and mechanical loading are anabolic for periprosthetic cancellous bone|
MJ Grosso, HW Courtland, X Yang, JP Sutherland, K Stoner, J Nguyen, ...
Journal of Orthopaedic Research 33 (2), 163-173, 2015
|Flapping flexible fish|
RG Root, HW Courtland, W Shepherd, JH Long
Animal Locomotion, 141-159, 2010