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Jeff Eastham
Jeff Eastham
Verified email at gene.com
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Year
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Y Zheng, DM Danilenko, P Valdez, I Kasman, J Eastham-Anderson, J Wu, ...
Nature 445 (7128), 648-651, 2007
24182007
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
M Schwickart, XD Huang, JR Lill, J Liu, R Ferrando, DM French, ...
Nature 463 (7277), 103-107, 2010
7222010
A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer
F de Sousa e Melo, AV Kurtova, JM Harnoss, N Kljavin, JD Hoeck, J Hung, ...
Nature 543 (7647), 676-680, 2017
5862017
Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial
S Vermeire, S O'Byrne, M Keir, M Williams, TT Lu, JC Mansfield, CA Lamb, ...
The Lancet 384 (9940), 309-318, 2014
5002014
Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)
JD Leverson, H Zhang, J Chen, SK Tahir, DC Phillips, J Xue, P Nimmer, ...
Cell death & disease 6 (1), e1590-e1590, 2015
4852015
B‐cell activation influences T‐cell polarization and outcome of anti‐CD20 B‐cell depletion in central nervous system autoimmunity
MS Weber, T Prod'Homme, JC Patarroyo, N Molnarfi, T Karnezis, ...
Annals of neurology 68 (3), 369-383, 2010
3292010
DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury
TA Watkins, B Wang, S Huntwork-Rodriguez, J Yang, Z Jiang, ...
Proceedings of the National Academy of Sciences 110 (10), 4039-4044, 2013
3002013
An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies
X Ye, Y Li, S Stawicki, S Couto, J Eastham-Anderson, D Kallop, R Weimer, ...
Oncogene 29 (38), 5254-5264, 2010
2522010
Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung
D Lafkas, A Shelton, C Chiu, G de Leon Boenig, Y Chen, SS Stawicki, ...
Nature 528 (7580), 127-131, 2015
2272015
Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1
CJ Spooner, J Lesch, D Yan, AA Khan, A Abbas, V Ramirez-Carrozzi, ...
Nature immunology 14 (12), 1229-1236, 2013
2052013
FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways
AL Wu, S Coulter, C Liddle, A Wong, J Eastham-Anderson, DM French, ...
PloS one 6 (3), e17868, 2011
2042011
Glucagon couples hepatic amino acid catabolism to mTOR-dependent regulation of α-cell mass
MJ Solloway, A Madjidi, C Gu, J Eastham-Anderson, HJ Clarke, N Kljavin, ...
Cell reports 12 (3), 495-510, 2015
1782015
PlGF blockade does not inhibit angiogenesis during primary tumor growth
C Bais, X Wu, J Yao, S Yang, Y Crawford, K McCutcheon, C Tan, ...
Cell 141 (1), 166-177, 2010
1782010
Association between response to etrolizumab and expression of integrin αE and granzyme A in colon biopsies of patients with ulcerative colitis
GW Tew, JA Hackney, D Gibbons, CA Lamb, D Luca, JG Egen, L Diehl, ...
Gastroenterology 150 (2), 477-487. e9, 2016
1622016
Targeting LGR5+ cells with an antibody-drug conjugate for the treatment of colon cancer
MR Junttila, W Mao, X Wang, BE Wang, T Pham, J Flygare, SF Yu, S Yee, ...
Science translational medicine 7 (314), 314ra186-314ra186, 2015
1592015
Suppression of HER2/HER3-mediated growth of breast cancer cells with combinations of GDC-0941 PI3K inhibitor, trastuzumab, and pertuzumab
E Yao, W Zhou, ST Lee-Hoeflich, T Truong, PM Haverty, ...
Clinical Cancer Research 15 (12), 4147-4156, 2009
1502009
Function of CSF1 and IL34 in macrophage homeostasis, inflammation, and cancer
WY Lin, D Xu, CD Austin, P Caplazi, K Senger, Y Sun, S Jeet, J Young, ...
Frontiers in immunology 10, 2019, 2019
1472019
MAP4K4 regulates integrin-FERM binding to control endothelial cell motility
P Vitorino, S Yeung, A Crow, J Bakke, T Smyczek, K West, E McNamara, ...
Nature 519 (7544), 425-430, 2015
1412015
Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells
W Chen, T Tang, J Eastham-Anderson, D Dunlap, B Alicke, M Nannini, ...
Proceedings of the National Academy of Sciences 108 (23), 9589-9594, 2011
1372011
Combined targeting of BRAF and CRAF or BRAF and PI3K effector pathways is required for efficacy in NRAS mutant tumors
BS Jaiswal, V Janakiraman, NM Kljavin, J Eastham-Anderson, JE Cupp, ...
Plos one 4 (5), e5717, 2009
1302009
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