|Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes|
JC Milne, PD Lambert, S Schenk, DP Carney, JJ Smith, DJ Gagne, L Jin, ...
Nature 450 (7170), 712-716, 2007
|Insulin sensitivity: modulation by nutrients and inflammation|
S Schenk, M Saberi, JM Olefsky
The Journal of clinical investigation 118 (9), 2992-3002, 2008
|A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange|
Y Liu, R Dentin, D Chen, S Hedrick, K Ravnskjaer, S Schenk, J Milne, ...
Nature 456 (7219), 269-273, 2008
|Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice|
M Saberi, NB Woods, C de Luca, S Schenk, JC Lu, G Bandyopadhyay, ...
Cell metabolism 10 (5), 419-429, 2009
|Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid–induced insulin resistance|
S Schenk, JF Horowitz
The Journal of clinical investigation 117 (6), 1690-1698, 2007
|SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes|
T Yoshizaki, JC Milne, T Imamura, S Schenk, N Sonoda, JL Babendure, ...
Molecular and cellular biology 29 (5), 1363-1374, 2009
|SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity|
T Yoshizaki, S Schenk, T Imamura, JL Babendure, N Sonoda, EJ Bae, ...
American journal of physiology-endocrinology and metabolism 298 (3), E419-E428, 2010
|Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity|
YS Lee, J Kim, O Osborne, R Sasik, S Schenk, A Chen, H Chung, ...
Cell 157 (6), 1339-1352, 2014
|NAD+/NADH and skeletal muscle mitochondrial adaptations to exercise|
AT White, S Schenk
American Journal of Physiology-Endocrinology and Metabolism 303 (3), E308-E321, 2012
|Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) deacetylation …|
A Philp, A Chen, D Lan, GA Meyer, AN Murphy, AE Knapp, IM Olfert, ...
Journal of Biological Chemistry 286 (35), 30561-30570, 2011
|Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance|
J Boon, AJ Hoy, R Stark, RD Brown, RC Meex, DC Henstridge, S Schenk, ...
Diabetes 62 (2), 401-410, 2013
|Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction|
S Schenk, CE McCurdy, A Philp, MZ Chen, MJ Holliday, ...
The Journal of clinical investigation 121 (11), 4281-4288, 2011
|Different glycemic indexes of breakfast cereals are not due to glucose entry into blood but to glucose removal by tissue|
S Schenk, CJ Davidson, TW Zderic, LO Byerley, EF Coyle
The American journal of clinical nutrition 78 (4), 742-748, 2003
|A high confidence, manually validated human blood plasma protein reference set|
S Schenk, GJ Schoenhals, G de Souza, M Mann
BMC medical genomics 1 (1), 41, 2008
|Coimmunoprecipitation of FAT/CD36 and CPT I in skeletal muscle increases proportionally with fat oxidation after endurance exercise training|
S Schenk, JF Horowitz
American Journal of Physiology-Endocrinology and Metabolism 291 (2), E254-E260, 2006
|High-fat diet elevates resting intramuscular triglyceride concentration and whole body lipolysis during exercise|
TW Zderic, CJ Davidson, S Schenk, LO Byerley, EF Coyle
American Journal of Physiology-Endocrinology and Metabolism 286 (2), E217-E225, 2004
|Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females|
V Ribas, BG Drew, Z Zhou, J Phun, NY Kalajian, T Soleymani, P Daraei, ...
Science translational medicine 8 (334), 334ra54-334ra54, 2016
|Discovery of Imidazo[1,2-b]thiazole Derivatives as Novel SIRT1 Activators|
CB Vu, JE Bemis, JS Disch, PY Ng, JJ Nunes, JC Milne, DP Carney, ...
Journal of medicinal chemistry 52 (5), 1275-1283, 2009
|Improved insulin sensitivity after weight loss and exercise training is mediated by a reduction in plasma fatty acid mobilization, not enhanced oxidative capacity|
S Schenk, MP Harber, CR Shrivastava, CF Burant, JF Horowitz
The Journal of physiology 587 (20), 4949-4961, 2009
|Regulation of plasma ceramide levels with fatty acid oversupply: evidence that the liver detects and secretes de novo synthesised ceramide|
MJ Watt, AC Barnett, CR Bruce, S Schenk, JF Horowitz, AJ Hoy
Diabetologia 55 (10), 2741-2746, 2012