| BNT162b vaccines protect rhesus macaques from SARS-CoV-2 AB Vogel, I Kanevsky, Y Che, KA Swanson, A Muik, M Vormehr, LM Kranz, ... Nature 592 (7853), 283-289, 2021 | 579 | 2021 |
| Crystal structure of the biphenyl-cleaving extradiol dioxygenase from a PCB-degrading pseudomonad S Han, LD Eltis, KN Timmis, SW Muchmore, JT Bolin Science 270 (5238), 976-980, 1995 | 424 | 1995 |
| Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair BR Chapados, DJ Hosfield, S Han, J Qiu, B Yelent, B Shen, JA Tainer Cell 116 (1), 39-50, 2004 | 339 | 2004 |
| Evolution and mechanism from structures of an ADP-ribosylating toxin and NAD complex S Han, JA Craig, CD Putnam, NB Carozzi, JA Tainer Nature structural biology 6 (10), 932-936, 1999 | 309 | 1999 |
| Crystal structure and novel recognition motif of rho ADP-ribosylating C3 exoenzyme from Clostridium botulinum: structural insights for recognition specificity and catalysis S Han, AS Arvai, SB Clancy, JA Tainer Journal of molecular biology 305 (1), 95-107, 2001 | 182 | 2001 |
| WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing JJP Perry, SM Yannone, LG Holden, C Hitomi, A Asaithamby, S Han, ... Nature structural & molecular biology 13 (5), 414-422, 2006 | 180 | 2006 |
| Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms MF Calabrese, F Rajamohan, MS Harris, NL Caspers, R Magyar, ... Structure 22 (8), 1161-1172, 2014 | 179 | 2014 |
| Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa S Han, RP Zaniewski, ES Marr, BM Lacey, AP Tomaras, A Evdokimov, ... Proceedings of the National Academy of Sciences 107 (51), 22002-22007, 2010 | 164 | 2010 |
| Redesigning and characterizing the substrate specificity and activity of Vibrio fluvialis aminotransferase for the synthesis of imagabalin KS Midelfort, R Kumar, S Han, MJ Karmilowicz, K McConnell, ... Protein Engineering, Design & Selection 26 (1), 25-33, 2013 | 155 | 2013 |
| A prefusion SARS-CoV-2 spike RNA vaccine is highly immunogenic and prevents lung infection in non-human primates AB Vogel, I Kanevsky, Y Che, KA Swanson, A Muik, M Vormehr, LM Kranz, ... BioRxiv, 2020.09. 08.280818, 2020 | 134 | 2020 |
| Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate … ML Vazquez, N Kaila, JW Strohbach, JD Trzupek, MF Brown, ... Journal of medicinal chemistry 61 (3), 1130-1152, 2018 | 134 | 2018 |
| Molecular mechanism of TRPV2 channel modulation by cannabidiol RA Pumroy, A Samanta, Y Liu, TET Hughes, S Zhao, Y Yudin, T Rohacs, ... Elife 8, e48792, 2019 | 131 | 2019 |
| Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism NG Fox, X Yu, X Feng, HJ Bailey, A Martelli, JF Nabhan, ... Nature communications 10 (1), 2210, 2019 | 131 | 2019 |
| Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent … KL Lee, CM Ambler, DR Anderson, BP Boscoe, AG Bree, JI Brodfuehrer, ... Journal of medicinal chemistry 60 (13), 5521-5542, 2017 | 126 | 2017 |
| Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design S Han, A Mistry, JS Chang, D Cunningham, M Griffor, PC Bonnette, ... Journal of biological chemistry 284 (19), 13193-13201, 2009 | 125 | 2009 |
| Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM TET Hughes, DT Lodowski, KW Huynh, A Yazici, J Del Rosario, A Kapoor, ... Nature structural & molecular biology 25 (1), 53-60, 2018 | 116 | 2018 |
| The ARTT motif and a unified structural understanding of substrate recognition in ADP-ribosylating bacterial toxins and eukaryotic ADP-ribosyltransferases S Han, JA Tainer International journal of medical microbiology 291 (6-7), 523-529, 2001 | 115 | 2001 |
| Tetrameric architecture of the circadian clock protein KaiB: a novel interface for intermolecular interactions and its impact on the circadian rhythm K Hitomi, T Oyama, S Han, AS Arvai, ED Getzoff Journal of Biological Chemistry 280 (19), 19127-19135, 2005 | 112 | 2005 |
| Molecular basis for the stabilization and inhibition of 2, 3-dihydroxybiphenyl 1, 2-dioxygenase by t-butanol FH Vaillancourt, S Han, PD Fortin, JT Bolin, LD Eltis Journal of Biological Chemistry 273 (52), 34887-34895, 1998 | 103 | 1998 |
| Imidazo [1, 5-a] quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis KH Kim, A Maderna, ME Schnute, M Hegen, S Mohan, J Miyashiro, L Lin, ... Bioorganic & medicinal chemistry letters 21 (21), 6258-6263, 2011 | 100 | 2011 |
